CYP4Z1 cytochrome P450 family 4 subfamily Z member 1 [Homo sapiens (human)] - Gene

Summary

Official Symbol: CYP4Z1provided by HGNC
Official Full Name: cytochrome P450 family 4 subfamily Z member 1provided by HGNC
Primary source: HGNC:HGNC:20583
See related: Ensembl:ENSG00000186160 MIM:618953; AllianceGenome:HGNC:20583
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: CYP4A20
Summary: This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This gene is part of a cluster of cytochrome P450 genes on chromosome 1p33. [provided by RefSeq, Jul 2008]
Expression: Low expression observed in reference dataset See more
Orthologs: all
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Genomic context

Location:: 1p33

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	1	NC_000001.11 (47055525..47118318)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	1	NC_060925.1 (46932944..46995763)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	1	NC_000001.10 (47532903..47583990)

Chromosome 1 - NC_000001.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Cytochrome 4Z1 Expression Connotes Unfavorable Prognosis in Ovarian Cancers.
Title: Cytochrome 4Z1 Expression Connotes Unfavorable Prognosis in Ovarian Cancers.
Profiling of CYP4Z1 and CYP1B1 expression in bladder cancers.
Title: Profiling of CYP4Z1 and CYP1B1 expression in bladder cancers.
Cytochrome 4Z1 Expression Is Correlated with Poor Prognosis in Patients with Cervical Cancer.
Title: Cytochrome 4Z1 Expression Is Correlated with Poor Prognosis in Patients with Cervical Cancer.
New Proluciferin Substrates for Human CYP4 Family Enzymes.
Title: New Proluciferin Substrates for Human CYP4 Family Enzymes.
Importance of asparagine-381 and arginine-487 for substrate recognition in CYP4Z1.
Title: Importance of asparagine-381 and arginine-487 for substrate recognition in CYP4Z1.
Transcriptional factor six2 promotes the competitive endogenous RNA network between CYP4Z1 and pseudogene CYP4Z2P responsible for maintaining the stemness of breast cancer cells.
Title: Transcriptional factor six2 promotes the competitive endogenous RNA network between CYP4Z1 and pseudogene CYP4Z2P responsible for maintaining the stemness of breast cancer cells.
We recently demonstrated the presence of the human CYP4Z1 on the plasma membrane of MCF-7 breast cancer cells and the detection of high titers of anti-CYP4Z1 aAbs in breast cancer patients, but not in healthy controls. In the present study we show that cells of the normal breast cell line MCF-10A do not display CYP4Z1 on their surface.
Title: Plasma membrane localization of CYP4Z1 and CYP19A1 and the detection of anti-CYP19A1 autoantibodies in humans.
If CYP4Z1 has a role to play in modulating cancer progression, new data form yeast microsomes expressing recombinant human enzyme suggest that the mechanism does not involve direct 20-HETE generation by this enzyme.
Title: Expression and Functional Characterization of Breast Cancer-Associated Cytochrome P450 4Z1 in Saccharomyces cerevisiae.
This study reports on the creation of a new homology model of CYP4Z1 and performed molecular docking experiments, which indicate that all active substrates show a highly similar binding geometry compared to the endogenous substrates.
Title: Efficient substrate screening and inhibitor testing of human CYP4Z1 using permeabilized recombinant fission yeast.
CYP4Z1 3'UTR could inhibit the migration and Epithelial-mesenchymal transition of breast cancer cells.
Title: CYP4Z1 3'UTR represses migration of human breast cancer cells.

Submit: New GeneRIF Correction See all GeneRIFs (18)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

General gene information

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Markers

SHGC-74767 (e-PCR)
- UniSTS:3360

SHGC-155105 (e-PCR)
- UniSTS:182057

NoName (e-PCR)
- UniSTS:483131

A009J39 (e-PCR)
- UniSTS:16701

STS-T92928 (e-PCR)
- UniSTS:50051

G32593 (e-PCR)
- UniSTS:117176

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables arachidonate 14,15-epoxygenase activity	IDA Inferred from Direct Assay more info	PubMed
enables fatty acid in-chain hydroxylase activity	IDA Inferred from Direct Assay more info	PubMed
enables heme binding	IEA Inferred from Electronic Annotation more info
enables iron ion binding	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in arachidonate metabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in lauric acid metabolic process	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in endoplasmic reticulum membrane	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: cytochrome P450 4Z1

Names: CYPIVZ1; cytochrome P450, family 4, subfamily Z, polypeptide 1; laurate 7-monooxygenase

NP_835235.1

EC 1.14.14.1

EC 1.14.14.130

XP_024309624.1

EC 1.14.14.1

EC 1.14.14.130

XP_054190878.1

EC 1.14.14.1

EC 1.14.14.130

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.