C5AR2 complement C5a receptor 2 [Homo sapiens (human)] - Gene

Summary

Official Symbol: C5AR2provided by HGNC
Official Full Name: complement C5a receptor 2provided by HGNC
Primary source: HGNC:HGNC:4527
See related: Ensembl:ENSG00000134830 MIM:609949; AllianceGenome:HGNC:4527
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: C5L2; GPF77; GPR77
Summary: This gene encodes a G-protein coupled receptor 1 family member involved in the complement system of the innate immune response. Unlike classical G-protein coupled receptors, the encoded protein does not associate with intracellular G-proteins. It may instead modulate signal transduction through the beta-arrestin pathway, and may alternatively act as a decoy receptor. This gene may be involved in coronary artery disease and in the pathogenesis of sepsis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2012]
Expression: Broad expression in spleen (RPKM 2.6), appendix (RPKM 1.3) and 16 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 19q13.32

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	19	NC_000019.10 (47332175..47347329)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	19	NC_060943.1 (50157644..50172793)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	19	NC_000019.9 (47835432..47850586)

Chromosome 19 - NC_000019.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

C5aR2 Regulates STING-Mediated Interferon Beta Production in Human Macrophages.
Title: C5aR2 Regulates STING-Mediated Interferon Beta Production in Human Macrophages.
C5L2 modulates BDNF production in human dental pulp stem cells via p38alpha pathway.
Title: C5L2 modulates BDNF production in human dental pulp stem cells via p38α pathway.
Differential expression of C5aR1 and C5aR2 in innate and adaptive immune cells located in early skin lesions of bullous pemphigoid patients.
Title: Differential expression of C5aR1 and C5aR2 in innate and adaptive immune cells located in early skin lesions of bullous pemphigoid patients.
C5aR2 Activation Broadly Modulates the Signaling and Function of Primary Human Macrophages.
Title: C5aR2 Activation Broadly Modulates the Signaling and Function of Primary Human Macrophages.
Expression of C5aR1 and C5aR2 in whole blood was significantly attenuated by IL-6R-inhibition in non-ST-elevation myocardial infarction patients.
Title: IL-6 Receptor Inhibition by Tocilizumab Attenuated Expression of C5a Receptor 1 and 2 in Non-ST-Elevation Myocardial Infarction.
Both rs2972607 and rs8112962 SNPs of C5L2 are associated with coronary artery disease in a Han population of China.
Title: Association of C5L2 genetic polymorphisms with coronary artery disease in a Han population in Xinjiang, China.
Studies indicate that the complement response lie the active fragments, C3a and C5a, acting through their specific receptors, C3aR, C5aR1 and C5aR2 to direct the cellular response to inflammation.
Title: New concepts on the therapeutic control of complement anaphylatoxin receptors.
negative regulator of BDNF secretion by pulp fibroblasts under carious teeth
Title: C5L2 Receptor Represses Brain-Derived Neurotrophic Factor Secretion in Lipoteichoic Acid-Stimulated Pulp Fibroblasts.
All the C698T genotypes and allele frequencies in C5L2 were almost similar in both the cases and controls.
Title: Genetic polymorphisms in paraoxonase 1 and G protein-coupled receptor 77, and the risk of glucose-6-phosphate dehydrogenase deficiency in a Saudi population.
C5AR and C5L2-mediated neutrophil dysfunction is associated with a poor outcome in sepsis.
Title: Complement 5a receptor-mediated neutrophil dysfunction is associated with a poor outcome in sepsis.

Submit: New GeneRIF Correction See all GeneRIFs (39)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

NoName (e-PCR)
- UniSTS:481654

GPR77_2341 (e-PCR)
- UniSTS:280737

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables G protein-coupled receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables complement component C5a receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in chemotaxis	IEA Inferred from Electronic Annotation more info
involved_in complement component C5a signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in complement receptor mediated signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in inflammatory response	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of interleukin-6 production	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of neutrophil chemotaxis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of tumor necrosis factor production	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in phospholipase C-activating G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of cytosolic calcium ion concentration	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of interleukin-8 production	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in apical part of cell	IDA Inferred from Direct Assay more info	PubMed
located_in basal plasma membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	TAS Traceable Author Statement more info

General protein information

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Preferred Names: C5a anaphylatoxin chemotactic receptor 2

Names: C5a anaphylatoxin chemotactic receptor C5L2; G protein-coupled receptor 77; G protein-coupled receptor C5L2; complement component 5a receptor 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001271749.2 → NP_001258678.1 C5a anaphylatoxin chemotactic receptor 2

See identical proteins and their annotated locations for NP_001258678.1

Status: REVIEWED

Description

Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2, and 3 encode the same protein.

Source sequence(s)

AB038237, AC008754, AK313994

Consensus CDS

CCDS12699.1

UniProtKB/Swiss-Prot

B2RA09, Q9P296

UniProtKB/TrEMBL

Q6NWQ8, Q6NWQ9

Related

ENSP00000472620.1, ENST00000595464.3

Conserved Domains (1) summary

pfam00001
Location:52 → 290

7tm_1; 7 transmembrane receptor (rhodopsin family)
NM_001271750.2 → NP_001258679.1 C5a anaphylatoxin chemotactic receptor 2

See identical proteins and their annotated locations for NP_001258679.1

Status: REVIEWED

Description

Transcript Variant: This variant (3) differs in the 5' UTR, compared to variant 1. Variants 1, 2, and 3 encode the same protein.

Source sequence(s)

AB038237, AC008754, BP370117

Consensus CDS

CCDS12699.1

UniProtKB/Swiss-Prot

B2RA09, Q9P296

UniProtKB/TrEMBL

Q6NWQ8, Q6NWQ9

Conserved Domains (1) summary

pfam00001
Location:52 → 290

7tm_1; 7 transmembrane receptor (rhodopsin family)
NM_018485.3 → NP_060955.1 C5a anaphylatoxin chemotactic receptor 2

See identical proteins and their annotated locations for NP_060955.1

Status: REVIEWED

Description

Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1, 2, and 3 encode the same protein.

Source sequence(s)

AB038237, AC008754, DA673976

Consensus CDS

CCDS12699.1

UniProtKB/Swiss-Prot

B2RA09, Q9P296

UniProtKB/TrEMBL

Q6NWQ8, Q6NWQ9

Related

ENSP00000471184.1, ENST00000600626.1

Conserved Domains (1) summary

pfam00001
Location:52 → 290

7tm_1; 7 transmembrane receptor (rhodopsin family)