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    PLGRKT plasminogen receptor with a C-terminal lysine [ Homo sapiens (human) ]

    Gene ID: 55848, updated on 10-Dec-2024

    Summary

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    Official Symbol
    PLGRKTprovided by HGNC
    Official Full Name
    plasminogen receptor with a C-terminal lysineprovided by HGNC
    Primary source
    HGNC:HGNC:23633
    See related
    Ensembl:ENSG00000107020 MIM:618444; AllianceGenome:HGNC:23633
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    AD025; MDS030; C9orf46; PLG-RKT; Plg-R(KT)
    Summary
    Predicted to be involved in positive regulation of plasminogen activation. Located in mitochondrion. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in colon (RPKM 12.9), duodenum (RPKM 11.8) and 24 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See PLGRKT in Genome Data Viewer
    Location:
    9p24.1
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 9 NC_000009.12 (5357971..5438377, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 9 NC_060933.1 (5363085..5447429, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (5357971..5437925, complement)

    Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr9:5327251-5327751 Neighboring gene high mobility group nucleosomal binding domain 2 pseudogene 31 Neighboring gene relaxin 2 Neighboring gene relaxin 1 Neighboring gene ReSE screen-validated silencer GRCh37_chr9:5418516-5418928 Neighboring gene ring finger protein 152 pseudogene 1 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr9:5437227-5438426 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28159 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28160 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28161 Neighboring gene uncharacterized LOC124902114 Neighboring gene Sharpr-MPRA regulatory region 9164 Neighboring gene OCT4 hESC enhancer GRCh37_chr9:5482138-5482639 Neighboring gene CD274 molecule Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28163 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28164 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28165 Neighboring gene Sharpr-MPRA regulatory region 6415 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:5501887-5502388 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr9:5509079-5510278 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28167 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28168 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28169 Neighboring gene programmed cell death 1 ligand 2 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28170 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19753 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28171

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Plg-R(KT) Expression in Human Breast Cancer Tissues. Miles LA, et al. Biomolecules, 2022 Mar 26. PMID 35454092, Free PMC Article
    2. The plasminogen receptor Plg-R(KT) regulates adipose function and metabolic homeostasis. Samad F, et al. J Thromb Haemost, 2022 Mar. PMID 34897983, Free PMC Article
    3. Exposure of plasminogen and a novel plasminogen receptor, Plg-RKT, on activated human and murine platelets. Whyte CS, et al. Blood, 2021 Jan 14. PMID 32842150, Free PMC Article
    4. The novel plasminogen receptor, plasminogen receptor(KT) (Plg-R(KT)), regulates catecholamine release. Bai H, et al. J Biol Chem, 2011 Sep 23. PMID 21795689, Free PMC Article
    5. Regulation of macrophage migration by a novel plasminogen receptor Plg-R KT. Lighvani S, et al. Blood, 2011 Nov 17. PMID 21940822, Free PMC Article

    See all (34) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Plg-RKT Expression in Human Breast Cancer Tissues.
      Title: Plg-R(KT) Expression in Human Breast Cancer Tissues.
    2. The plasminogen receptor Plg-RKT regulates adipose function and metabolic homeostasis.
      Title: The plasminogen receptor Plg-R(KT) regulates adipose function and metabolic homeostasis.
    3. Exposure of plasminogen and a novel plasminogen receptor, Plg-RKT, on activated human and murine platelets.
      Title: Exposure of plasminogen and a novel plasminogen receptor, Plg-RKT, on activated human and murine platelets.
    4. Plasminogen and the Plasminogen Receptor, Plg-RKT, Regulate Macrophage Phenotypic, and Functional Changes.
      Title: Plasminogen and the Plasminogen Receptor, Plg-R(KT), Regulate Macrophage Phenotypic, and Functional Changes.
    5. Plg-R(KT) was highly expressed in bovine adrenomedullary chromaffin cells, human pheochromocytoma tissue, PC12 pheochromocytoma cells, and murine hippocampus.
      Title: The novel plasminogen receptor, plasminogen receptor(KT) (Plg-R(KT)), regulates catecholamine release.
    6. Plg-R(KT) plays a key role in the plasminogen-dependent regulation of macrophage invasion, chemotactic migration, and recruitment in the inflammatory response.
      Title: Regulation of macrophage migration by a novel plasminogen receptor Plg-R KT.
    7. Observational study of gene-disease association. (HuGE Navigator)
      Title: Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.
    8. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
      Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ14688, FLJ39176

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in chemotaxis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in inflammatory response IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of plasminogen activation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in mitochondrion HTP PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    plasminogen receptor (KT)
    Names
    5033414D02Rik
    plasminogen receptor, C-terminal lysine transmembrane protein
    transmembrane protein C9orf46

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_018465.4 → NP_060935.2  plasminogen receptor (KT)

      See identical proteins and their annotated locations for NP_060935.2

      Status: VALIDATED

      Source sequence(s)
      AA919015, AK027594, BM693747
      Consensus CDS
      CCDS6463.1
      UniProtKB/Swiss-Prot
      B2R6W0, Q9HBL7, Q9NZ44
      Related
      ENSP00000223864.2, ENST00000223864.7
      Conserved Domains (1) summary
      pfam10166
      Location:1 → 134
      DUF2368; Uncharacterized conserved protein (DUF2368)

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000009.12 Reference GRCh38.p14 Primary Assembly

      Range
      5357971..5438377 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005251510.6 → XP_005251567.1  plasminogen receptor (KT) isoform X1

      See identical proteins and their annotated locations for XP_005251567.1

      UniProtKB/Swiss-Prot
      B2R6W0, Q9HBL7, Q9NZ44
      Conserved Domains (1) summary
      pfam10166
      Location:1 → 134
      DUF2368; Uncharacterized conserved protein (DUF2368)

    2. XM_011517960.3 → XP_011516262.1  plasminogen receptor (KT) isoform X1

      See identical proteins and their annotated locations for XP_011516262.1

      UniProtKB/Swiss-Prot
      B2R6W0, Q9HBL7, Q9NZ44
      Conserved Domains (1) summary
      pfam10166
      Location:1 → 134
      DUF2368; Uncharacterized conserved protein (DUF2368)

    3. XM_005251512.5 → XP_005251569.1  plasminogen receptor (KT) isoform X2

      Conserved Domains (1) summary
      pfam10166
      Location:1 → 101
      DUF2368; uncharacterized conserved protein (DUF2368)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060933.1 Alternate T2T-CHM13v2.0

      Range
      5363085..5447429 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054363281.1 → XP_054219256.1  plasminogen receptor (KT) isoform X1

      UniProtKB/Swiss-Prot
      B2R6W0, Q9HBL7, Q9NZ44

    2. XM_054363282.1 → XP_054219257.1  plasminogen receptor (KT) isoform X1

      UniProtKB/Swiss-Prot
      B2R6W0, Q9HBL7, Q9NZ44

    3. XM_054363283.1 → XP_054219258.1  plasminogen receptor (KT) isoform X2

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9HBL7.1 GenPept UniProtKB/Swiss-Prot:Q9HBL7

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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