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These reference sequences exist independently of genome builds. Explain
These reference sequences are curated independently of the genome
annotation cycle, so their versions may not match the RefSeq versions in the current
genome build. Identify version mismatches by comparing the version of the RefSeq in
this section to the one reported in Genomic regions,
transcripts, and products above.
Genomic
-
NG_015849.2 RefSeqGene
- Range
-
4981..65636
- Download
- GenBank, FASTA, Sequence Viewer (Graphics)
mRNA and Protein(s)
-
NM_001166278.2 → NP_001159750.1 disks large homolog 3 isoform c
See identical proteins and their annotated locations for NP_001159750.1
Status: REVIEWED
- Description
- Transcript Variant: This variant (3) differs in the 5' UTR and has multiple coding region differences, compared to variant 1. Translation initiates at a downstream AUG and results in an isoform (c) that is shorter than isoform a.
- Source sequence(s)
-
AB033058, AK303377, CK300381
- Consensus CDS
-
CCDS55439.1
- UniProtKB/Swiss-Prot
-
Q92796
- Related
- ENSP00000441393.1, ENST00000542398.1
- Conserved Domains (2) summary
-
- pfam00625
Location:175 → 353
- Guanylate_kin; Guanylate kinase
- cl17036
Location:19 → 85
- SH3; Src Homology 3 domain superfamily
-
NM_020730.3 → NP_065781.1 disks large homolog 3 isoform b
See identical proteins and their annotated locations for NP_065781.1
Status: REVIEWED
- Description
- Transcript Variant: This variant (2) differs in the 5' UTR and has multiple coding region differences, compared to variant 1. Translation initiates at an alternate AUG and results in an isoform (b) that is shorter and has a distinct N-terminus compared to isoform a.
- Source sequence(s)
-
AB033058, AL139398, CK300381, CN357435
- Consensus CDS
-
CCDS43967.1
- UniProtKB/Swiss-Prot
-
Q92796
- Related
- ENSP00000363475.3, ENST00000374355.8
- Conserved Domains (3) summary
-
- cd00992
Location:47 → 125
- PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
- pfam00625
Location:321 → 499
- Guanylate_kin; Guanylate kinase
- cl17036
Location:165 → 231
- SH3; Src Homology 3 domain superfamily
-
NM_021120.4 → NP_066943.2 disks large homolog 3 isoform a
See identical proteins and their annotated locations for NP_066943.2
Status: REVIEWED
- Description
- Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a).
- Source sequence(s)
-
AB033058, AB209328, AL139398, BC093866, CK300381
- Consensus CDS
-
CCDS14403.1
- UniProtKB/Swiss-Prot
- B4E0H1, D3DVU5, Q5JUW6, Q5JUW7, Q92796, Q9ULI8
- UniProtKB/TrEMBL
-
Q5JUW8
- Related
- ENSP00000363480.3, ENST00000374360.8
- Conserved Domains (5) summary
-
- cd12029
Location:502 → 568
- SH3_DLG3; Src Homology 3 domain of Disks Large homolog 3
- cd00992
Location:384 → 462
- PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
- pfam00625
Location:626 → 804
- Guanylate_kin; Guanylate kinase
- pfam10600
Location:311 → 385
- PDZ_assoc; PDZ-associated domain of NMDA receptors
- pfam10608
Location:52 → 130
- MAGUK_N_PEST; Polyubiquitination (PEST) N-terminal domain of MAGUK
The following sections contain reference sequences that belong to a
specific genome build. Explain
This section includes genomic Reference
Sequences (RefSeqs) from all assemblies on which this gene is annotated, such as
RefSeqs for chromosomes and scaffolds (contigs) from both reference and alternate
assemblies. Model RNAs and proteins are also reported here.
Reference GRCh38.p14 Primary Assembly
Genomic
-
NC_000023.11 Reference GRCh38.p14 Primary Assembly
- Range
-
70444835..70505490
- Download
- GenBank, FASTA, Sequence Viewer (Graphics)
mRNA and Protein(s)
-
XM_006724625.3 → XP_006724688.1 disks large homolog 3 isoform X1
See identical proteins and their annotated locations for XP_006724688.1
- UniProtKB/TrEMBL
-
Q5JUW8
- Conserved Domains (5) summary
-
- cd12029
Location:502 → 568
- SH3_DLG3; Src Homology 3 domain of Disks Large homolog 3
- cd00992
Location:384 → 462
- PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
- pfam00625
Location:658 → 836
- Guanylate_kin; Guanylate kinase
- pfam10600
Location:311 → 385
- PDZ_assoc; PDZ-associated domain of NMDA receptors
- pfam10608
Location:52 → 130
- MAGUK_N_PEST; Polyubiquitination (PEST) N-terminal domain of MAGUK
-
XM_011530883.2 → XP_011529185.1 disks large homolog 3 isoform X2
- UniProtKB/TrEMBL
-
Q5JUW8
- Conserved Domains (5) summary
-
- cd12029
Location:502 → 568
- SH3_DLG3; Src Homology 3 domain of Disks Large homolog 3
- cd00992
Location:384 → 462
- PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
- pfam00625
Location:644 → 822
- Guanylate_kin; Guanylate kinase
- pfam10600
Location:311 → 385
- PDZ_assoc; PDZ-associated domain of NMDA receptors
- pfam10608
Location:52 → 130
- MAGUK_N_PEST; Polyubiquitination (PEST) N-terminal domain of MAGUK
-
XM_006724626.3 → XP_006724689.1 disks large homolog 3 isoform X3
See identical proteins and their annotated locations for XP_006724689.1
- UniProtKB/TrEMBL
-
Q5JUW8
- Related
- ENSP00000194900.4, ENST00000194900.8
- Conserved Domains (5) summary
-
- cd12029
Location:502 → 568
- SH3_DLG3; Src Homology 3 domain of Disks Large homolog 3
- cd00992
Location:384 → 462
- PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
- pfam00625
Location:640 → 818
- Guanylate_kin; Guanylate kinase
- pfam10600
Location:311 → 385
- PDZ_assoc; PDZ-associated domain of NMDA receptors
- pfam10608
Location:52 → 130
- MAGUK_N_PEST; Polyubiquitination (PEST) N-terminal domain of MAGUK
-
XM_017029322.3 → XP_016884811.1 disks large homolog 3 isoform X4
-
XM_017029323.3 → XP_016884812.1 disks large homolog 3 isoform X5
-
XM_017029324.3 → XP_016884813.1 disks large homolog 3 isoform X6
-
XM_005262248.5 → XP_005262305.1 disks large homolog 3 isoform X8
See identical proteins and their annotated locations for XP_005262305.1
- UniProtKB/Swiss-Prot
-
Q92796
- Conserved Domains (2) summary
-
- pfam00625
Location:175 → 353
- Guanylate_kin; Guanylate kinase
- cl17036
Location:19 → 85
- SH3; Src Homology 3 domain superfamily
-
XM_047441886.1 → XP_047297842.1 disks large homolog 3 isoform X8
-
XM_047441885.1 → XP_047297841.1 disks large homolog 3 isoform X8
-
XM_047441884.1 → XP_047297840.1 disks large homolog 3 isoform X8
-
XM_047441887.1 → XP_047297843.1 disks large homolog 3 isoform X8
-
XM_047441888.1 → XP_047297844.1 disks large homolog 3 isoform X9
-
XM_017029327.2 → XP_016884816.1 disks large homolog 3 isoform X10
-
XM_047441883.1 → XP_047297839.1 disks large homolog 3 isoform X8
-
XM_017029325.3 → XP_016884814.1 disks large homolog 3 isoform X7
Alternate T2T-CHM13v2.0
Genomic
-
NC_060947.1 Alternate T2T-CHM13v2.0
- Range
-
68878160..68938810
- Download
- GenBank, FASTA, Sequence Viewer (Graphics)
mRNA and Protein(s)
-
XM_054326603.1 → XP_054182578.1 disks large homolog 3 isoform X1
- UniProtKB/TrEMBL
-
Q5JUW8
-
XM_054326604.1 → XP_054182579.1 disks large homolog 3 isoform X2
- UniProtKB/TrEMBL
-
Q5JUW8
-
XM_054326605.1 → XP_054182580.1 disks large homolog 3 isoform X3
- UniProtKB/TrEMBL
-
Q5JUW8
-
XM_054326606.1 → XP_054182581.1 disks large homolog 3 isoform X4
-
XM_054326607.1 → XP_054182582.1 disks large homolog 3 isoform X5
-
XM_054326608.1 → XP_054182583.1 disks large homolog 3 isoform X6
-
XM_054326611.1 → XP_054182586.1 disks large homolog 3 isoform X8
-
XM_054326614.1 → XP_054182589.1 disks large homolog 3 isoform X8
-
XM_054326613.1 → XP_054182588.1 disks large homolog 3 isoform X8
-
XM_054326612.1 → XP_054182587.1 disks large homolog 3 isoform X8
-
XM_054326615.1 → XP_054182590.1 disks large homolog 3 isoform X8
-
XM_054326616.1 → XP_054182591.1 disks large homolog 3 isoform X9
-
XM_054326617.1 → XP_054182592.1 disks large homolog 3 isoform X10
-
XM_054326610.1 → XP_054182585.1 disks large homolog 3 isoform X8
-
XM_054326609.1 → XP_054182584.1 disks large homolog 3 isoform X7