Sirt5 sirtuin 5 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Sirt5provided by MGI
Official Full Name: sirtuin 5provided by MGI
Primary source: MGI:MGI:1915596
See related: Ensembl:ENSMUSG00000054021 AllianceGenome:MGI:1915596
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 0610012J09Rik; 1500032M05Rik
Summary: Enables protein-glutaryllysine deglutarylase activity; protein-malonyllysine demalonylase activity; and protein-succinyllysine desuccinylase activity. Involved in protein deacylation and regulation of ketone biosynthetic process. Acts upstream of or within regulation of succinate dehydrogenase activity and response to ischemia. Located in cytosol and mitochondrial inner membrane. Is expressed in several structures, including 1st branchial arch maxillary component; heart; oocyte; palatal shelf; and sensory organ. Orthologous to human SIRT5 (sirtuin 5). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in heart adult (RPKM 3.8), bladder adult (RPKM 2.9) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 13 A4; 13 21.6 cM

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	13	NC_000079.7 (43518849..43549073)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	13	NC_000079.6 (43365389..43395203)

Chromosome 13 - NC_000079.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

SIRT5 mutants reveal the role of conserved asparagine and glutamine residues in the NAD[+]-binding pocket.
Title: SIRT5 mutants reveal the role of conserved asparagine and glutamine residues in the NAD(+)-binding pocket.
SIRTUIN 5 ALLEVIATES EXCESSIVE MITOCHONDRIAL FISSION VIA DESUCCINYLATION OF ATPASE INHIBITORY FACTOR 1 IN SEPSIS-INDUCED ACUTE KIDNEY INJURY.
Title: SIRTUIN 5 ALLEVIATES EXCESSIVE MITOCHONDRIAL FISSION VIA DESUCCINYLATION OF ATPASE INHIBITORY FACTOR 1 IN SEPSIS-INDUCED ACUTE KIDNEY INJURY.
Sirt5 improves cardiomyocytes fatty acid metabolism and ameliorates cardiac lipotoxicity in diabetic cardiomyopathy via CPT2 de-succinylation.
Title: Sirt5 improves cardiomyocytes fatty acid metabolism and ameliorates cardiac lipotoxicity in diabetic cardiomyopathy via CPT2 de-succinylation.
Dual modifying of MAVS at lysine 7 by SIRT3-catalyzed deacetylation and SIRT5-catalyzed desuccinylation orchestrates antiviral innate immunity.
Title: Dual modifying of MAVS at lysine 7 by SIRT3-catalyzed deacetylation and SIRT5-catalyzed desuccinylation orchestrates antiviral innate immunity.
Sirtuin 5 Alleviates Liver Ischemia/Reperfusion Injury by Regulating Mitochondrial Succinylation and Oxidative Stress.
Title: Sirtuin 5 Alleviates Liver Ischemia/Reperfusion Injury by Regulating Mitochondrial Succinylation and Oxidative Stress.
SIRT5-related lysine demalonylation of GSTP1 contributes to cardiomyocyte pyroptosis suppression in diabetic cardiomyopathy.
Title: SIRT5-related lysine demalonylation of GSTP1 contributes to cardiomyocyte pyroptosis suppression in diabetic cardiomyopathy.
CircARF3 Mitigates Allergic Rhinitis through Targeting microRNA-205-5p/Sirtuin 5 Axis.
Title: CircARF3 Mitigates Allergic Rhinitis through Targeting microRNA-205-5p/Sirtuin 5 Axis.
The deacylase sirtuin 5 reduces malonylation in nonmitochondrial metabolic pathways in diabetic kidney disease.
Title: The deacylase sirtuin 5 reduces malonylation in nonmitochondrial metabolic pathways in diabetic kidney disease.
A new view on functions of the lysine demalonylase activity of SIRT5.
Title: A new view on functions of the lysine demalonylase activity of SIRT5.
In-depth analysis of the Sirtuin 5-regulated mouse brain malonylome and succinylome using library-free data-independent acquisitions.
Title: In-depth analysis of the Sirtuin 5-regulated mouse brain malonylome and succinylome using library-free data-independent acquisitions.

Submit: New GeneRIF Correction See all GeneRIFs (65)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (5)
Targeted (5) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Sirt5 (e-PCR), detects polymorphism
- UniSTS:531297

Sirt5 (e-PCR), detects polymorphism
- UniSTS:531298

AV001953 (e-PCR)
- UniSTS:164522

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables NAD+ binding	IBA Inferred from Biological aspect of Ancestor more info
enables NAD+ binding	IEA Inferred from Electronic Annotation more info
enables NAD+ binding	ISO Inferred from Sequence Orthology more info
enables NAD-dependent protein lysine deacetylase activity	IEA Inferred from Electronic Annotation more info
enables histone deacetylase activity, NAD-dependent	IBA Inferred from Biological aspect of Ancestor more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein-glutaryllysine deglutarylase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein-glutaryllysine deglutarylase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein-glutaryllysine deglutarylase activity	ISO Inferred from Sequence Orthology more info
enables protein-malonyllysine demalonylase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein-malonyllysine demalonylase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein-malonyllysine demalonylase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables protein-malonyllysine demalonylase activity	ISO Inferred from Sequence Orthology more info
enables protein-succinyllysine desuccinylase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein-succinyllysine desuccinylase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein-succinyllysine desuccinylase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables protein-succinyllysine desuccinylase activity	ISO Inferred from Sequence Orthology more info
enables zinc ion binding	IEA Inferred from Electronic Annotation more info
enables zinc ion binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in negative regulation of cardiac muscle cell apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of reactive oxygen species metabolic process	ISO Inferred from Sequence Orthology more info
involved_in peptidyl-lysine demalonylation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in peptidyl-lysine demalonylation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within peptidyl-lysine desuccinylation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in peptidyl-lysine desuccinylation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in peptidyl-lysine desuccinylation	ISO Inferred from Sequence Orthology more info
involved_in protein deacetylation	ISO Inferred from Sequence Orthology more info
NOT involved_in protein deacetylation	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein deglutarylation	IDA Inferred from Direct Assay more info	PubMed
involved_in protein deglutarylation	ISO Inferred from Sequence Orthology more info
involved_in protein demalonylation	IDA Inferred from Direct Assay more info	PubMed
involved_in protein demalonylation	ISO Inferred from Sequence Orthology more info
involved_in protein desuccinylation	IDA Inferred from Direct Assay more info	PubMed
involved_in protein desuccinylation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein desuccinylation	ISO Inferred from Sequence Orthology more info
involved_in regulation of ketone biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of succinate dehydrogenase activity	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within response to ischemia	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in mitochondrial inner membrane	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrial intermembrane space	ISO Inferred from Sequence Orthology more info
located_in mitochondrial intermembrane space	ISS Inferred from Sequence or Structural Similarity more info
is_active_in mitochondrial matrix	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrial matrix	ISO Inferred from Sequence Orthology more info
located_in mitochondrial matrix	ISS Inferred from Sequence or Structural Similarity more info
located_in mitochondrion	HDA more info	PubMed
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrion	IDA Inferred from Direct Assay more info	PubMed
is_active_in mitochondrion	IMP Inferred from Mutant Phenotype more info	PubMed
located_in mitochondrion	ISO Inferred from Sequence Orthology more info
located_in mitochondrion	ISS Inferred from Sequence or Structural Similarity more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	TAS Traceable Author Statement more info	PubMed

General protein information

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Preferred Names: NAD-dependent protein deacylase sirtuin-5, mitochondrial

Names: NAD-dependent deacetylase sirtuin-5; NAD-dependent lysine demalonylase and desuccinylase sirtuin-5, mitochondrial

NP_849179.1

EC 2.3.1.-

EC 3.5.1.-

XP_006517014.1

EC 2.3.1.-

EC 3.5.1.-

XP_006517015.1

EC 2.3.1.-

EC 3.5.1.-

XP_006517016.1

EC 2.3.1.-

EC 3.5.1.-

XP_006517017.1

EC 2.3.1.-

EC 3.5.1.-

XP_011242714.1

EC 2.3.1.-

EC 3.5.1.-

XP_011242715.1

EC 2.3.1.-

EC 3.5.1.-

XP_030103247.1

EC 2.3.1.-

EC 3.5.1.-

XP_030103248.1

EC 2.3.1.-

EC 3.5.1.-

XP_030103249.1

EC 2.3.1.-

EC 3.5.1.-

XP_030103250.1

EC 2.3.1.-

EC 3.5.1.-

XP_036014035.1

EC 2.3.1.-

EC 3.5.1.-

XP_036014036.1

EC 2.3.1.-

EC 3.5.1.-

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_178848.3 → NP_849179.1 NAD-dependent protein deacylase sirtuin-5, mitochondrial

See identical proteins and their annotated locations for NP_849179.1

Status: PROVISIONAL

Source sequence(s)

AC132121

Consensus CDS

CCDS26478.1

UniProtKB/Swiss-Prot

Q8K2C6

UniProtKB/TrEMBL

A0A1Y7VJY8

Related

ENSMUSP00000152796.2, ENSMUST00000223194.2

Conserved Domains (1) summary

cd01412
Location:51 → 301

SIRT5_Af1_CobB; Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000079.7 Reference GRCm39 C57BL/6J

Range

43518849..43549073

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006516951.3 → XP_006517014.1 NAD-dependent protein deacylase sirtuin-5, mitochondrial isoform X1

See identical proteins and their annotated locations for XP_006517014.1

UniProtKB/TrEMBL

A0A1Y7VJY8, A0A1Y7VM56

Conserved Domains (1) summary

cd01412
Location:51 → 289

SIRT5_Af1_CobB; Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD ...
XM_006516954.2 → XP_006517017.1 NAD-dependent protein deacylase sirtuin-5, mitochondrial isoform X3

Conserved Domains (1) summary

cl00195
Location:4 → 181

SIR2; SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+, ...
XM_036158143.1 → XP_036014036.1 NAD-dependent protein deacylase sirtuin-5, mitochondrial isoform X4

Conserved Domains (1) summary

cl00195
Location:4 → 179

SIR2; SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+, ...
XM_030247387.2 → XP_030103247.1 NAD-dependent protein deacylase sirtuin-5, mitochondrial isoform X2

UniProtKB/Swiss-Prot

Q8K2C6

UniProtKB/TrEMBL

A0A1Y7VJY8

Related

ENSMUSP00000152740.2, ENSMUST00000220576.2

Conserved Domains (1) summary

cd01412
Location:51 → 301

SIRT5_Af1_CobB; Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD ...
XM_036158142.1 → XP_036014035.1 NAD-dependent protein deacylase sirtuin-5, mitochondrial isoform X3

Conserved Domains (1) summary

cl00195
Location:4 → 181

SIR2; SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+, ...
XM_006516953.3 → XP_006517016.1 NAD-dependent protein deacylase sirtuin-5, mitochondrial isoform X1

See identical proteins and their annotated locations for XP_006517016.1

UniProtKB/TrEMBL

A0A1Y7VJY8, A0A1Y7VM56

Related

ENSMUSP00000152526.2, ENSMUST00000221515.2

Conserved Domains (1) summary

cd01412
Location:51 → 289

SIRT5_Af1_CobB; Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD ...
XM_006516952.5 → XP_006517015.1 NAD-dependent protein deacylase sirtuin-5, mitochondrial isoform X1

See identical proteins and their annotated locations for XP_006517015.1

UniProtKB/TrEMBL

A0A1Y7VJY8, A0A1Y7VM56

Conserved Domains (1) summary

cd01412
Location:51 → 289

SIRT5_Af1_CobB; Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD ...
XM_030247390.2 → XP_030103250.1 NAD-dependent protein deacylase sirtuin-5, mitochondrial isoform X4

Conserved Domains (1) summary

cl00195
Location:4 → 179

SIR2; SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+, ...
XM_030247388.2 → XP_030103248.1 NAD-dependent protein deacylase sirtuin-5, mitochondrial isoform X2

UniProtKB/Swiss-Prot

Q8K2C6

UniProtKB/TrEMBL

A0A1Y7VJY8

Conserved Domains (1) summary

cd01412
Location:51 → 301

SIRT5_Af1_CobB; Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD ...
XM_011244413.3 → XP_011242715.1 NAD-dependent protein deacylase sirtuin-5, mitochondrial isoform X1

See identical proteins and their annotated locations for XP_011242715.1

UniProtKB/TrEMBL

A0A1Y7VJY8, A0A1Y7VM56

Conserved Domains (1) summary

cd01412
Location:51 → 289

SIRT5_Af1_CobB; Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD ...
XM_030247389.2 → XP_030103249.1 NAD-dependent protein deacylase sirtuin-5, mitochondrial isoform X2

UniProtKB/Swiss-Prot

Q8K2C6

UniProtKB/TrEMBL

A0A1Y7VJY8

Conserved Domains (1) summary

cd01412
Location:51 → 301

SIRT5_Af1_CobB; Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD ...
XM_011244412.3 → XP_011242714.1 NAD-dependent protein deacylase sirtuin-5, mitochondrial isoform X1

See identical proteins and their annotated locations for XP_011242714.1

UniProtKB/TrEMBL

A0A1Y7VJY8, A0A1Y7VM56

Conserved Domains (1) summary

cd01412
Location:51 → 289

SIRT5_Af1_CobB; Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD ...