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    Fam171a1 family with sequence similarity 171, member A1 [ Mus musculus (house mouse) ]

    Gene ID: 269233, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Fam171a1provided by MGI
    Official Full Name
    family with sequence similarity 171, member A1provided by MGI
    Primary source
    MGI:MGI:2442917
    See related
    Ensembl:ENSMUSG00000050530 AllianceGenome:MGI:2442917
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    9630050M13Rik
    Summary
    Predicted to be involved in regulation of cell shape and stress fiber assembly. Predicted to be active in plasma membrane. Is expressed in glossopharyngeal ganglion; medulla oblongata basal plate mantle layer; trigeminal ganglion; and trigeminal nerve. Orthologous to human FAM171A1 (family with sequence similarity 171 member A1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in ovary adult (RPKM 16.1), lung adult (RPKM 15.4) and 26 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Fam171a1 in Genome Data Viewer
    Location:
    2 A1; 2 1.73 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (3115261..3228843)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (3114224..3227806)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_03510 Neighboring gene predicted gene, 54098 Neighboring gene STARR-seq mESC enhancer starr_03511 Neighboring gene predicted gene, 22005 Neighboring gene N-myristoyltransferase 2 Neighboring gene STARR-positive B cell enhancer ABC_E999 Neighboring gene ribonuclease P/MRP 38 subunit Neighboring gene acyl-Coenzyme A binding domain containing 7

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders. Li J, et al. Nat Neurosci, 2017 Aug. PMID 28671696, Free PMC Article
    2. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article
    3. Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas. Watahiki A, et al. Nat Methods, 2004 Dec. PMID 15782199
    4. Genetic determinants of micronucleus formation in vivo. Adams DJ, et al. Nature, 2024 Mar. PMID 38355793, Free PMC Article
    5. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulation of cell shape IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of cell shape ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in stress fiber assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in stress fiber assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    protein FAM171A1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001081161.2 → NP_001074630.1  protein FAM171A1 isoform 1

      See identical proteins and their annotated locations for NP_001074630.1

      Status: VALIDATED

      Source sequence(s)
      AL928883
      Consensus CDS
      CCDS38036.1
      UniProtKB/TrEMBL
      A2ATK9
      Related
      ENSMUSP00000110751.3, ENSMUST00000115099.9
      Conserved Domains (1) summary
      pfam10577
      Location:34 → 890
      UPF0560; uncharacterized protein family UPF0560

    2. NM_001310434.1 → NP_001297363.1  protein FAM171A1 isoform 2

      See identical proteins and their annotated locations for NP_001297363.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) has an alternate 5' most exon which results in the use of a downstream AUG compared to variant 1. The encoded isoform (2) has a shorter N-terminus compared to isoform 1.
      Source sequence(s)
      AA030185, AK036270, AL928883
      Consensus CDS
      CCDS79727.1
      UniProtKB/TrEMBL
      A2ATL1
      Related
      ENSMUSP00000072724.6, ENSMUST00000072955.12
      Conserved Domains (1) summary
      pfam10577
      Location:1 → 765
      UPF0560; uncharacterized protein family UPF0560

    3. NM_001347067.2 → NP_001333996.1  protein FAM171A1 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AK077831, AL928883
      Consensus CDS
      CCDS84464.1
      UniProtKB/TrEMBL
      A2ATL0
      Related
      ENSMUSP00000053619.7, ENSMUST00000062934.7

    4. NM_001361386.1 → NP_001348315.1  protein FAM171A1 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AK032237, AL928883, BC048735, CB525292
      Consensus CDS
      CCDS89424.1
      UniProtKB/TrEMBL
      A2ATK8
      Related
      ENSMUSP00000089086.5, ENSMUST00000091505.11
      Conserved Domains (1) summary
      pfam10577
      Location:34 → 292
      UPF0560; Uncharacterized protein family UPF0560

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      3115261..3228843
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006497479.3 → XP_006497542.1  protein FAM171A1 isoform X2

      Conserved Domains (1) summary
      pfam10577
      Location:34 → 831
      UPF0560; Uncharacterized protein family UPF0560

    2. XM_006497478.3 → XP_006497541.1  protein FAM171A1 isoform X1

      Conserved Domains (1) summary
      pfam10577
      Location:34 → 859
      UPF0560; Uncharacterized protein family UPF0560

    3. XM_036162236.1 → XP_036018129.1  protein FAM171A1 isoform X3

      Conserved Domains (1) summary
      pfam10577
      Location:35 → 532
      UPF0560; Uncharacterized protein family UPF0560

    4. XM_030251634.2 → XP_030107494.1  protein FAM171A1 isoform X3

      Conserved Domains (1) summary
      pfam10577
      Location:35 → 532
      UPF0560; Uncharacterized protein family UPF0560
    Nucleotide Protein Strain
    Heading Accession and Version

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