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    Tagln3 transgelin 3 [ Mus musculus (house mouse) ]

    Gene ID: 56370, updated on 9-Dec-2024

    Summary

    Official Symbol
    Tagln3provided by MGI
    Official Full Name
    transgelin 3provided by MGI
    Primary source
    MGI:MGI:1926784
    See related
    Ensembl:ENSMUSG00000022658 AllianceGenome:MGI:1926784
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Np25; 2700038H05Rik; 2900005O10Rik
    Summary
    Predicted to enable actin filament binding activity. Acts upstream of or within negative regulation of transcription by RNA polymerase II. Located in nucleus. Is active in synapse. Is expressed in central nervous system; gut; olfactory epithelium; peripheral nervous system; and retina. Orthologous to human TAGLN3 (transgelin 3). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in cerebellum adult (RPKM 204.8), CNS E14 (RPKM 149.6) and 5 other tissues See more
    Orthologs
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    Genomic context

    See Tagln3 in Genome Data Viewer
    Location:
    16 B5; 16 29.99 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (45531591..45545271, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (45711230..45724531, complement)

    Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene cDNA sequence, BC016579 Neighboring gene STARR-seq mESC enhancer starr_40918 Neighboring gene transmembrane serine protease 7 Neighboring gene STARR-seq mESC enhancer starr_40919 Neighboring gene STARR-seq mESC enhancer starr_40920 Neighboring gene STARR-seq mESC enhancer starr_40921 Neighboring gene abhydrolase domain containing 10 Neighboring gene pleckstrin homology like domain, family B, member 2 Neighboring gene STARR-seq mESC enhancer starr_40922 Neighboring gene predicted gene 15638

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    Interactions

    General gene information

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables actin filament binding  
    enables molecular_function  
    Component Evidence Code Pubs
    is_active_in actin cytoskeleton  
    located_in myelin sheath PubMed 
    located_in nucleus PubMed 
    is_active_in synapse PubMed 
    is_active_in synapse PubMed 
    is_active_in synapse PubMed 

    General protein information

    Preferred Names
    transgelin-3
    Names
    neuronal protein Np25

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_019754.3NP_062728.1  transgelin-3

      See identical proteins and their annotated locations for NP_062728.1

      Status: PROVISIONAL

      Source sequence(s)
      BC055338
      Consensus CDS
      CCDS28200.1
      UniProtKB/Swiss-Prot
      Q9R1Q8
      Related
      ENSMUSP00000093762.5, ENSMUST00000096057.5
      Conserved Domains (2) summary
      pfam00402
      Location:174198
      Calponin; Calponin family repeat
      cd21281
      Location:23141
      CH_TAGLN3; calponin homology (CH) domain found in transgelin-3

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000082.7 Reference GRCm39 C57BL/6J

      Range
      45531591..45545271 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    RNA

    1. XR_004939202.1 RNA Sequence

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