Vangl2 VANGL planar cell polarity 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Vangl2provided by MGI
Official Full Name: VANGL planar cell polarity 2provided by MGI
Primary source: MGI:MGI:2135272
See related: Ensembl:ENSMUSG00000026556 AllianceGenome:MGI:2135272
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Lp; Lpp1; Ltap; stbm; Lootl; ska17; Vang1l2; loop-tail; strabismus; ska<m17Jus>; C530001F03Rik
Summary: Involved in several processes, including Wnt signaling pathway, planar cell polarity pathway; axon guidance; and morphogenesis of an epithelium. Acts upstream of or within several processes, including inner ear development; morphogenesis of an epithelium; and ventricular septum morphogenesis. Located in several cellular components, including basolateral plasma membrane; lateral plasma membrane; and stress fiber. Is active in glutamatergic synapse and postsynaptic density membrane. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; respiratory system epithelium; and sensory organ. Used to study neural tube defect. Human ortholog(s) of this gene implicated in neural tube defect. Orthologous to human VANGL2 (VANGL planar cell polarity protein 2). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Broad expression in CNS E11.5 (RPKM 15.1), whole brain E14.5 (RPKM 14.6) and 19 other tissues See more
Orthologs: human all
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Genomic context

Location:: 1 H3; 1 79.54 cM

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	1	NC_000067.7 (171828527..171856532, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	1	NC_000067.6 (172000960..172027318, complement)

Chromosome 1 - NC_000067.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Vangl2 suppresses NF-kappaB signaling and ameliorates sepsis by targeting p65 for NDP52-mediated autophagic degradation.
Title: Vangl2 suppresses NF-κB signaling and ameliorates sepsis by targeting p65 for NDP52-mediated autophagic degradation.
Mesenchymal Vangl1 and Vangl2 facilitate airway elongation and widening independently of the planar cell polarity complex.
Title: Mesenchymal Vangl1 and Vangl2 facilitate airway elongation and widening independently of the planar cell polarity complex.
Van Gogh-like 2 is essential for the architectural patterning of the mammalian biliary tree.
Title: Van Gogh-like 2 is essential for the architectural patterning of the mammalian biliary tree.
Vangl-dependent mesenchymal thinning shapes the distal lung during murine sacculation.
Title: Vangl-dependent mesenchymal thinning shapes the distal lung during murine sacculation.
VANGL2 inhibits antiviral IFN-I signaling by targeting TBK1 for autophagic degradation.
Title: VANGL2 inhibits antiviral IFN-I signaling by targeting TBK1 for autophagic degradation.
An unanticipated discourse of HB-EGF with VANGL2 signaling during embryo implantation.
Title: An unanticipated discourse of HB-EGF with VANGL2 signaling during embryo implantation.
Functional interaction between Vangl2 and N-cadherin regulates planar cell polarization of the developing neural tube and cochlear sensory epithelium.
Title: Functional interaction between Vangl2 and N-cadherin regulates planar cell polarization of the developing neural tube and cochlear sensory epithelium.
Vangl2-environment interaction causes severe neural tube defects, without abnormal neuroepithelial convergent extension.
Title: Vangl2-environment interaction causes severe neural tube defects, without abnormal neuroepithelial convergent extension.
The cell polarity protein Vangl2 in the muscle shapes the neuromuscular synapse by binding to and regulating the tyrosine kinase MuSK.
Title: The cell polarity protein Vangl2 in the muscle shapes the neuromuscular synapse by binding to and regulating the tyrosine kinase MuSK.
Vangl2 acts at the interface between actin and N-cadherin to modulate mammalian neuronal outgrowth.
Title: Vangl2 acts at the interface between actin and N-cadherin to modulate mammalian neuronal outgrowth.

Submit: New GeneRIF Correction See all GeneRIFs (75)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Chemically induced (ENU) (3) 1 citation
Endonuclease-mediated (5) 1 citation
Spontaneous (2)
Targeted (11) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

G42042 (e-PCR)
- UniSTS:105067

Vangl2 (e-PCR), detects polymorphism
- UniSTS:546531

Vangl2 (e-PCR), detects polymorphism
- UniSTS:532468

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within Rho protein signal transduction	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in Wnt signaling pathway, planar cell polarity pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within Wnt signaling pathway, planar cell polarity pathway	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within Wnt signaling pathway, planar cell polarity pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in Wnt signaling pathway, planar cell polarity pathway	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within anterior/posterior pattern specification	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within apical protein localization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in branching involved in blood vessel morphogenesis	TAS Traceable Author Statement more info	PubMed
involved_in cardiac vascular smooth muscle cell differentiation	TAS Traceable Author Statement more info	PubMed
involved_in cell migration involved in kidney development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cochlea development	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within cochlea morphogenesis	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within cochlea morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within convergent extension involved in axis elongation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within convergent extension involved in neural plate elongation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within convergent extension involved in neural plate elongation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within convergent extension involved in organogenesis	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within digestive tract morphogenesis	IGI Inferred from Genetic Interaction more info	PubMed
involved_in dopaminergic neuron axon guidance	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in epicardial cell to mesenchymal cell transition	TAS Traceable Author Statement more info	PubMed
acts_upstream_of_or_within establishment of body hair planar orientation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in establishment of epithelial cell polarity	TAS Traceable Author Statement more info	PubMed
involved_in establishment of planar polarity	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within establishment of planar polarity	IGI Inferred from Genetic Interaction more info	PubMed
involved_in establishment of planar polarity	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within establishment of planar polarity involved in neural tube closure	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within establishment or maintenance of epithelial cell apical/basal polarity	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within glomerulus development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within hair follicle development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in heart looping	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within heparan sulfate proteoglycan biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within inner ear receptor cell development	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within inner ear receptor cell stereocilium organization	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within inner ear receptor cell stereocilium organization	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within kidney morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within lateral sprouting involved in lung morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within membranous septum morphogenesis	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within muscular septum morphogenesis	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within neural tube closure	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within neural tube closure	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within non-canonical Wnt signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within non-motile cilium assembly	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within orthogonal dichotomous subdivision of terminal units involved in lung branching morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in outflow tract septum morphogenesis	TAS Traceable Author Statement more info	PubMed
acts_upstream_of_or_within planar dichotomous subdivision of terminal units involved in lung branching morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of JUN kinase activity	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within post-anal tail morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of Wnt signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of actin cytoskeleton organization	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of establishment of planar polarity	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of synapse pruning	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of synapse pruning	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in serotonergic neuron axon guidance	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within somatic stem cell division	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within somatic stem cell population maintenance	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within wound healing	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
located_in COPII-coated ER to Golgi transport vesicle	IDA Inferred from Direct Assay more info	PubMed
located_in apical cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in apical plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in basolateral plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in cell periphery	IDA Inferred from Direct Assay more info	PubMed
located_in cell pole	IDA Inferred from Direct Assay more info	PubMed
located_in cell-cell junction	IDA Inferred from Direct Assay more info	PubMed
is_active_in glutamatergic synapse	IDA Inferred from Direct Assay more info	PubMed
located_in lateral plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	ISS Inferred from Sequence or Structural Similarity more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	TAS Traceable Author Statement more info
is_active_in postsynaptic density membrane	IDA Inferred from Direct Assay more info	PubMed
located_in stress fiber	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: vang-like protein 2

Names: loop tail associated protein; loop-tail protein 1; van Gogh-like protein 2; vang-like 2 (van gogh, Drosophila)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_033509.4 → NP_277044.1 vang-like protein 2

See identical proteins and their annotated locations for NP_277044.1

Status: VALIDATED

Source sequence(s)

AC158930, AF365875, AK049613, AK082938, AW046551, BC075636, BY320814

Consensus CDS

CCDS15505.1

UniProtKB/Swiss-Prot

Q91ZD4, Q923Z8

UniProtKB/TrEMBL

D3YY75

Related

ENSMUSP00000027837.7, ENSMUST00000027837.13

Conserved Domains (1) summary

pfam06638
Location:34 → 521

Strabismus; Strabismus protein

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000067.7 Reference GRCm39 C57BL/6J

Range

171828527..171856532 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036154495.1 → XP_036010388.1 vang-like protein 2 isoform X1

UniProtKB/Swiss-Prot

Q91ZD4, Q923Z8

UniProtKB/TrEMBL

D3YY75

Conserved Domains (1) summary

pfam06638
Location:34 → 521

Strabismus; Strabismus protein
XM_006497051.5 → XP_006497114.1 vang-like protein 2 isoform X1

See identical proteins and their annotated locations for XP_006497114.1

UniProtKB/Swiss-Prot

Q91ZD4, Q923Z8

UniProtKB/TrEMBL

D3YY75

Conserved Domains (1) summary

pfam06638
Location:34 → 521

Strabismus; Strabismus protein
XM_006497053.5 → XP_006497116.1 vang-like protein 2 isoform X1

See identical proteins and their annotated locations for XP_006497116.1

UniProtKB/Swiss-Prot

Q91ZD4, Q923Z8

UniProtKB/TrEMBL

D3YY75

Conserved Domains (1) summary

pfam06638
Location:34 → 521

Strabismus; Strabismus protein
XM_006497052.5 → XP_006497115.1 vang-like protein 2 isoform X1

See identical proteins and their annotated locations for XP_006497115.1

UniProtKB/Swiss-Prot

Q91ZD4, Q923Z8

UniProtKB/TrEMBL

D3YY75

Conserved Domains (1) summary

pfam06638
Location:34 → 521

Strabismus; Strabismus protein
XM_036154494.1 → XP_036010387.1 vang-like protein 2 isoform X1

UniProtKB/Swiss-Prot

Q91ZD4, Q923Z8

UniProtKB/TrEMBL

D3YY75

Conserved Domains (1) summary

pfam06638
Location:34 → 521

Strabismus; Strabismus protein
XM_006497054.5 → XP_006497117.1 vang-like protein 2 isoform X1

See identical proteins and their annotated locations for XP_006497117.1

UniProtKB/Swiss-Prot

Q91ZD4, Q923Z8

UniProtKB/TrEMBL

D3YY75

Conserved Domains (1) summary

pfam06638
Location:34 → 521

Strabismus; Strabismus protein
XM_017313008.3 → XP_017168497.1 vang-like protein 2 isoform X1

UniProtKB/Swiss-Prot

Q91ZD4, Q923Z8

UniProtKB/TrEMBL

D3YY75

Conserved Domains (1) summary

pfam06638
Location:34 → 521

Strabismus; Strabismus protein