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    Srr serine racemase [ Mus musculus (house mouse) ]

    Gene ID: 27364, updated on 9-Dec-2024

    Summary

    Official Symbol
    Srrprovided by MGI
    Official Full Name
    serine racemaseprovided by MGI
    Primary source
    MGI:MGI:1351636
    See related
    Ensembl:ENSMUSG00000001323 AllianceGenome:MGI:1351636
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Srs; Rgsc34; M100034
    Summary
    Enables several functions, including amino-acid racemase activity; anion binding activity; and identical protein binding activity. Acts upstream of or within D-serine biosynthetic process and L-serine metabolic process. Predicted to be located in apical part of cell and neuronal cell body. Predicted to be active in cytoplasm. Is expressed in facial bone primordium and nervous system. Used to study schizophrenia. Orthologous to human SRR (serine racemase). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in frontal lobe adult (RPKM 12.8), cortex adult (RPKM 12.1) and 28 other tissues See more
    Orthologs
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    Genomic context

    See Srr in Genome Data Viewer
    Location:
    11 B5; 11 45.76 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (74794853..74818427, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (74904027..74927533, complement)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E7015 Neighboring gene max binding protein Neighboring gene small G protein signaling modulator 2 Neighboring gene microRNA 6926 Neighboring gene small nucleolar RNA, C/D box 91A Neighboring gene TSR1 20S rRNA accumulation Neighboring gene STARR-seq mESC enhancer starr_29979 Neighboring gene predicted gene, 22733 Neighboring gene SMG6 nonsense mediated mRNA decay factor Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:74826503-74826738 Neighboring gene SMT3 suppressor of mif two 3 homolog 2 pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Chemically induced (ENU) (9)  1 citation
    • Endonuclease-mediated (1) 
    • Gene trapped (2) 
    • Targeted (7)  1 citation

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables ATP binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables ATP binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables D-serine ammonia-lyase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables L-serine ammonia-lyase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables L-serine ammonia-lyase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables L-serine ammonia-lyase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables PDZ domain binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables PDZ domain binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables calcium ion binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables glycine binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables magnesium ion binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables magnesium ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables magnesium ion binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein homodimerization activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables pyridoxal phosphate binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables pyridoxal phosphate binding IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables pyridoxal phosphate binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables serine racemase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables serine racemase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables serine racemase activity ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    enables threonine racemase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables threonine racemase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in apical part of cell IEA
    Inferred from Electronic Annotation
    more info
     
    located_in apical part of cell ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in neuronal cell body IEA
    Inferred from Electronic Annotation
    more info
     
    located_in neuronal cell body ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    serine racemase
    Names
    D-serine ammonia-lyase
    D-serine dehydratase
    L-serine ammonia-lyase
    L-serine dehydratase
    NP_001156783.1
    NP_001349671.1
    NP_001349672.1
    NP_001349673.1
    NP_038789.1
    XP_006533520.1
    XP_011247359.1
    XP_017170060.1
    XP_030101905.1
    XP_030101906.1
    XP_036012631.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001163311.2NP_001156783.1  serine racemase isoform 1

      See identical proteins and their annotated locations for NP_001156783.1

      Status: VALIDATED

      Source sequence(s)
      AB232342, AK043738, AK079343, AL604066, BY475189
      Consensus CDS
      CCDS25038.1
      UniProtKB/Swiss-Prot
      Q401M7, Q5SWE4, Q5SWE5, Q5SWE7, Q8BT19, Q8CD11, Q9QZX7
      Related
      ENSMUSP00000113372.2, ENSMUST00000121738.8
      Conserved Domains (1) summary
      cl00342
      Location:5322
      Trp-synth-beta_II; Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan ...
    2. NM_001362742.1NP_001349671.1  serine racemase isoform 2

      Status: VALIDATED

      Source sequence(s)
      AK031687, AL604066
      Consensus CDS
      CCDS88190.1
      Related
      ENSMUSP00000104086.2, ENSMUST00000108447.8
      Conserved Domains (1) summary
      cl00342
      Location:5297
      Trp-synth-beta_II; Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan ...
    3. NM_001362743.1NP_001349672.1  serine racemase isoform 3

      Status: VALIDATED

      Source sequence(s)
      AL604066
      Conserved Domains (1) summary
      cl00342
      Location:5267
      Trp-synth-beta_II; Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan ...
    4. NM_001362744.1NP_001349673.1  serine racemase isoform 4

      Status: VALIDATED

      Source sequence(s)
      AK079343, AL604066
      Conserved Domains (1) summary
      cl00342
      Location:1180
      Trp-synth-beta_II; Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan ...
    5. NM_013761.5NP_038789.1  serine racemase isoform 1

      See identical proteins and their annotated locations for NP_038789.1

      Status: VALIDATED

      Source sequence(s)
      AB232342, AK043738, AK079343, AL604066, BY475189
      Consensus CDS
      CCDS25038.1
      UniProtKB/Swiss-Prot
      Q401M7, Q5SWE4, Q5SWE5, Q5SWE7, Q8BT19, Q8CD11, Q9QZX7
      Related
      ENSMUSP00000067552.3, ENSMUST00000065211.9
      Conserved Domains (1) summary
      cl00342
      Location:5322
      Trp-synth-beta_II; Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan ...

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      74794853..74818427 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011249057.4XP_011247359.1  serine racemase isoform X2

      Conserved Domains (1) summary
      cl00342
      Location:5267
      Trp-synth-beta_II; Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan ...
    2. XM_036156738.1XP_036012631.1  serine racemase isoform X2

      Conserved Domains (1) summary
      cl00342
      Location:5267
      Trp-synth-beta_II; Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan ...
    3. XM_017314571.3XP_017170060.1  serine racemase isoform X3

      UniProtKB/Swiss-Prot
      Q401M7, Q5SWE4, Q5SWE5, Q5SWE7, Q8BT19, Q8CD11, Q9QZX7
      Conserved Domains (1) summary
      cl00342
      Location:5322
      Trp-synth-beta_II; Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan ...
    4. XM_006533457.5XP_006533520.1  serine racemase isoform X3

      See identical proteins and their annotated locations for XP_006533520.1

      UniProtKB/Swiss-Prot
      Q401M7, Q5SWE4, Q5SWE5, Q5SWE7, Q8BT19, Q8CD11, Q9QZX7
      Conserved Domains (1) summary
      cl00342
      Location:5322
      Trp-synth-beta_II; Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan ...
    5. XM_030246045.2XP_030101905.1  serine racemase isoform X1

      Conserved Domains (1) summary
      cl00342
      Location:5267
      Trp-synth-beta_II; Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan ...
    6. XM_030246046.2XP_030101906.1  serine racemase isoform X2

      Conserved Domains (1) summary
      cl00342
      Location:5267
      Trp-synth-beta_II; Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan ...