U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Fzd6 frizzled class receptor 6 [ Mus musculus (house mouse) ]

    Gene ID: 14368, updated on 3-Dec-2024

    Summary

    Official Symbol
    Fzd6provided by MGI
    Official Full Name
    frizzled class receptor 6provided by MGI
    Primary source
    MGI:MGI:108474
    See related
    Ensembl:ENSMUSG00000022297 AllianceGenome:MGI:108474
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Fz6; rst
    Summary
    Enables Wnt-protein binding activity. Acts upstream of or within several processes, including cell proliferation in midbrain; embryonic morphogenesis; and establishment of body hair planar orientation. Located in apical plasma membrane; apicolateral plasma membrane; and endoplasmic reticulum membrane. Is expressed in several structures, including alimentary system; brain; genitourinary system; integumental system; and sensory organ. Human ortholog(s) of this gene implicated in nonsyndromic congenital nail disorder 1. Orthologous to human FZD6 (frizzled class receptor 6). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in bladder adult (RPKM 8.3), limb E14.5 (RPKM 5.7) and 26 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Fzd6 in Genome Data Viewer
    Location:
    15 B3.1; 15
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (38869673..38901587)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (39006149..39038192)

    Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_38469 Neighboring gene predicted gene, 33123 Neighboring gene ATPase family, AAA domain containing 3A pseudogene Neighboring gene STARR-seq mESC enhancer starr_38470 Neighboring gene predicted gene, 26704 Neighboring gene predicted gene, 24789 Neighboring gene predicted gene 7194

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables G protein-coupled receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables Wnt receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables Wnt receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables Wnt receptor activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables Wnt-protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables Wnt-protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables ubiquitin protein ligase binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables ubiquitin protein ligase binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within Wnt signaling pathway, planar cell polarity pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in canonical Wnt signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within cell proliferation in midbrain IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within embryonic nail plate morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within establishment of body hair planar orientation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within establishment of planar polarity IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within hair follicle development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within inner ear morphogenesis IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within midbrain development IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in negative regulation of DNA-binding transcription factor activity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of canonical Wnt signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of canonical Wnt signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within neural tube closure IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in non-canonical Wnt signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in non-canonical Wnt signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within platelet activation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in apical part of cell IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in apical plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in apicolateral plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cell surface IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytoplasmic vesicle membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in endoplasmic reticulum membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
     

    General protein information

    Preferred Names
    frizzled-6
    Names
    frizzled homolog 6
    fz-6
    mFz6

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001162494.1NP_001155966.1  frizzled-6 isoform 1 precursor

      See identical proteins and their annotated locations for NP_001155966.1

      Status: VALIDATED

      Source sequence(s)
      AC164883, AK138964, BB613669, BE648857, CD348842
      Consensus CDS
      CCDS27441.1
      UniProtKB/Swiss-Prot
      Q61089
      UniProtKB/TrEMBL
      Q542J1, Q8R382
      Related
      ENSMUSP00000136328.2, ENSMUST00000179165.9
      Conserved Domains (2) summary
      cd07450
      Location:20146
      CRD_FZ6; Cysteine-rich Wnt-binding domain (CRD) of the frizzled 6 (Fz6) receptor
      cd15032
      Location:188508
      7tmF_FZD6; class F frizzled subfamily 6, member of 7-transmembrane G protein-coupled receptors
    2. NM_001411226.1NP_001398155.1  frizzled-6 isoform 1 precursor

      Status: VALIDATED

      Source sequence(s)
      AC164883
      UniProtKB/Swiss-Prot
      Q61089
      UniProtKB/TrEMBL
      Q542J1, Q8R382
    3. NM_001411227.1NP_001398156.1  frizzled-6 isoform 2 precursor

      Status: VALIDATED

      Source sequence(s)
      AC164883
    4. NM_008056.4NP_032082.3  frizzled-6 isoform 1 precursor

      See identical proteins and their annotated locations for NP_032082.3

      Status: VALIDATED

      Source sequence(s)
      AC164883
      Consensus CDS
      CCDS27441.1
      UniProtKB/Swiss-Prot
      Q61089
      UniProtKB/TrEMBL
      Q542J1, Q8R382
      Related
      ENSMUSP00000022906.8, ENSMUST00000022906.8
      Conserved Domains (2) summary
      cd07450
      Location:20146
      CRD_FZ6; Cysteine-rich Wnt-binding domain (CRD) of the frizzled 6 (Fz6) receptor
      cd15032
      Location:188508
      7tmF_FZD6; class F frizzled subfamily 6, member of 7-transmembrane G protein-coupled receptors

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000081.7 Reference GRCm39 C57BL/6J

      Range
      38869673..38901587
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036159158.1XP_036015051.1  frizzled-6 isoform X4

      Conserved Domains (2) summary
      cd07450
      Location:20146
      CRD_FZ6; Cysteine-rich Wnt-binding domain (CRD) of the frizzled 6 (Fz6) receptor
      cd15032
      Location:188464
      7tmF_FZD6; class F frizzled subfamily 6, member of 7-transmembrane G protein-coupled receptors
    2. XM_006520438.4XP_006520501.1  frizzled-6 isoform X2

      See identical proteins and their annotated locations for XP_006520501.1

      UniProtKB/TrEMBL
      Q8R382
      Conserved Domains (2) summary
      cd15032
      Location:139459
      7tmF_FZD6; class F frizzled subfamily 6, member of 7-transmembrane G protein-coupled receptors
      cl02447
      Location:897
      CRD_FZ; CRD_domain cysteine-rich domain, also known as Fz (frizzled) domain
    3. XM_036159156.1XP_036015049.1  frizzled-6 isoform X1

      UniProtKB/Swiss-Prot
      Q61089
      UniProtKB/TrEMBL
      Q542J1, Q8R382
      Conserved Domains (2) summary
      cd07450
      Location:20146
      CRD_FZ6; Cysteine-rich Wnt-binding domain (CRD) of the frizzled 6 (Fz6) receptor
      cd15032
      Location:188508
      7tmF_FZD6; class F frizzled subfamily 6, member of 7-transmembrane G protein-coupled receptors
    4. XM_011245454.3XP_011243756.1  frizzled-6 isoform X2

      See identical proteins and their annotated locations for XP_011243756.1

      UniProtKB/TrEMBL
      Q8R382
      Conserved Domains (2) summary
      cd15032
      Location:139459
      7tmF_FZD6; class F frizzled subfamily 6, member of 7-transmembrane G protein-coupled receptors
      cl02447
      Location:897
      CRD_FZ; CRD_domain cysteine-rich domain, also known as Fz (frizzled) domain