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    Dcstamp dendrocyte expressed seven transmembrane protein [ Mus musculus (house mouse) ]

    Gene ID: 75766, updated on 9-Dec-2024

    Summary

    Official Symbol
    Dcstampprovided by MGI
    Official Full Name
    dendrocyte expressed seven transmembrane proteinprovided by MGI
    Primary source
    MGI:MGI:1923016
    See related
    Ensembl:ENSMUSG00000022303 AllianceGenome:MGI:1923016
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    FIND; Tm7sf4; DC-STAMP; mDC-STAMP; 4833414I07Rik
    Summary
    Involved in several processes, including cellular response to cytokine stimulus; myeloid leukocyte differentiation; and positive regulation of bone resorption. Located in cell surface; endoplasmic reticulum membrane; and endosome membrane. Orthologous to human DCSTAMP (dendrocyte expressed seven transmembrane protein). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Low expression observed in reference dataset See more
    Orthologs
    NEW
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    Genomic context

    See Dcstamp in Genome Data Viewer
    Location:
    15 B3.1; 15 15.51 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (39609326..39624334)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (39745930..39760938)

    Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene Neighboring gene STARR-seq mESC enhancer starr_38478 Neighboring gene regulating synaptic membrane exocytosis 2 Neighboring gene STARR-seq mESC enhancer starr_38479 Neighboring gene STARR-seq mESC enhancer starr_38480 Neighboring gene U6 snRNA-associated Sm-like protein LSm3 pseudogene Neighboring gene STARR-seq mESC enhancer starr_38483 Neighboring gene STARR-seq mESC enhancer starr_38487 Neighboring gene STARR-seq mESC enhancer starr_38490 Neighboring gene STARR-seq mESC enhancer starr_38492 Neighboring gene dihydropyrimidinase Neighboring gene predicted gene 16291 Neighboring gene predicted gene, 53879

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (5) 
    • Targeted (1)  1 citation

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Process Evidence Code Pubs
    involved_in cellular response to interleukin-4 ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to interleukin-4 ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in cellular response to macrophage colony-stimulating factor stimulus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in cellular response to transforming growth factor beta stimulus IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular response to tumor necrosis factor IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in membrane fusion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in membrane fusion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in myeloid dendritic cell differentiation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of cell growth IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in osteoclast differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within osteoclast fusion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in osteoclast fusion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in osteoclast fusion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of bone resorption IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of macrophage fusion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of macrophage fusion IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in positive regulation of macrophage fusion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of monocyte differentiation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in cell surface IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cell surface IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cell surface ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in endoplasmic reticulum membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in endoplasmic reticulum membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in endoplasmic reticulum membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in endoplasmic reticulum membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in endoplasmic reticulum-Golgi intermediate compartment membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in endosome membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in membrane NAS
    Non-traceable Author Statement
    more info
    PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    dendritic cell-specific transmembrane protein
    Names
    dentrocyte expressed seven transmembrane protein
    transmembrane 7 superfamily member 4

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001289506.1NP_001276435.1  dendritic cell-specific transmembrane protein isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses ans alternate splice site compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
      Source sequence(s)
      AC158776
      UniProtKB/TrEMBL
      B7ZP05
      Conserved Domains (1) summary
      pfam07782
      Location:242420
      DC_STAMP; DC-STAMP-like protein
    2. NM_001289508.1NP_001276437.1  dendritic cell-specific transmembrane protein isoform 3

      See identical proteins and their annotated locations for NP_001276437.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) uses an alternate splice site compared to variant 1. The encoded isoform (3) is shorter than isoform 1.
      Source sequence(s)
      AB109561, AC158776
      Consensus CDS
      CCDS88758.1
      UniProtKB/TrEMBL
      B7ZP05
      Related
      ENSMUSP00000154397.2, ENSMUST00000227368.2
      Conserved Domains (1) summary
      pfam07782
      Location:242365
      DC_STAMP; DC-STAMP-like protein
    3. NM_001289512.1NP_001276441.1  dendritic cell-specific transmembrane protein isoform 4

      See identical proteins and their annotated locations for NP_001276441.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) lacks an in-frame exon in the 3' coding region compared to variant 1. The encoded isoform (4) is shorter than isoform 1.
      Source sequence(s)
      AC158776, AK014697
      Consensus CDS
      CCDS88759.1
      UniProtKB/Swiss-Prot
      Q7TNJ0
      Related
      ENSMUSP00000154362.2, ENSMUST00000228556.2
      Conserved Domains (1) summary
      pfam07782
      Location:242356
      DC_STAMP; DC-STAMP-like protein
    4. NM_001289513.1NP_001276442.1  dendritic cell-specific transmembrane protein isoform 5

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) uses two alternate splice sites in the coding region, one of which results in a frame shift compared to variant 1. The encoded isoform (5) is shorter and has a distinct C-terminus compared to isoform 1.
      Source sequence(s)
      AC158776
      Consensus CDS
      CCDS88757.1
      UniProtKB/TrEMBL
      A0A2I3BPX1, B7ZP05
      Related
      ENSMUSP00000153957.2, ENSMUST00000227792.2
      Conserved Domains (1) summary
      pfam07782
      Location:242365
      DC_STAMP; DC-STAMP-like protein
    5. NM_029422.4NP_083698.1  dendritic cell-specific transmembrane protein isoform 1

      See identical proteins and their annotated locations for NP_083698.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AC158776, AY517483
      Consensus CDS
      CCDS27444.1
      UniProtKB/Swiss-Prot
      B2RT61, Q6R315, Q7TNI9, Q7TNJ0, Q9D619
      UniProtKB/TrEMBL
      Q3U482
      Related
      ENSMUSP00000022913.5, ENSMUST00000022913.6
      Conserved Domains (1) summary
      pfam07782
      Location:242421
      DC_STAMP; DC-STAMP-like protein

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000081.7 Reference GRCm39 C57BL/6J

      Range
      39609326..39624334
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006521519.3XP_006521582.1  dendritic cell-specific transmembrane protein isoform X1

      Conserved Domains (1) summary
      pfam07782
      Location:57236
      DC_STAMP; DC-STAMP-like protein