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    Zfpm2 zinc finger protein, multitype 2 [ Mus musculus (house mouse) ]

    Gene ID: 22762, updated on 9-Dec-2024

    Summary

    Official Symbol
    Zfpm2provided by MGI
    Official Full Name
    zinc finger protein, multitype 2provided by MGI
    Primary source
    MGI:MGI:1334444
    See related
    Ensembl:ENSMUSG00000022306 AllianceGenome:MGI:1334444
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    FOG2; FOG-2; B330005D23Rik
    Summary
    Enables transcription corepressor activity. Involved in several processes, including negative regulation of female gonad development; positive regulation of cardiac muscle cell proliferation; and positive regulation of male gonad development. Acts upstream of or within several processes, including circulatory system development; in utero embryonic development; and regulation of transcription by RNA polymerase II. Located in cytoplasm and male germ cell nucleus. Is expressed in several structures, including brain; embryo mesenchyme; genitourinary system; gut; and heart and pericardium. Used to study congenital diaphragmatic hernia; tetralogy of Fallot; and tricuspid atresia. Human ortholog(s) of this gene implicated in 46,XY sex reversal 9; congenital diaphragmatic hernia; myelodysplastic syndrome; and tetralogy of Fallot. Orthologous to human ZFPM2 (zinc finger protein, FOG family member 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in cerebellum adult (RPKM 6.0), CNS E14 (RPKM 3.9) and 17 other tissues See more
    Orthologs
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    Genomic context

    See Zfpm2 in Genome Data Viewer
    Location:
    15 B3.1; 15 15.74 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (40518438..40967988)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (40655042..41104592)

    Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene predicted gene 16294 Neighboring gene actin related protein 2/3 complex, subunit 1B pseudogene Neighboring gene STARR-seq mESC enhancer starr_38506 Neighboring gene mbt domain containing 1 pseudogene Neighboring gene peptidylprolyl isomerase A pseudogene 25 Neighboring gene predicted gene, 33353 Neighboring gene STARR-seq mESC enhancer starr_38507 Neighboring gene STARR-seq mESC enhancer starr_38508 Neighboring gene STARR-seq mESC enhancer starr_38510 Neighboring gene leucine rich repeat and sterile alpha motif containing 1 pseudogene Neighboring gene STARR-seq mESC enhancer starr_38511 Neighboring gene STARR-seq mESC enhancer starr_38512 Neighboring gene STARR-seq mESC enhancer starr_38513 Neighboring gene STARR-seq mESC enhancer starr_38514 Neighboring gene predicted gene, 46502 Neighboring gene STARR-seq mESC enhancer starr_38515 Neighboring gene STARR-seq mESC enhancer starr_38516 Neighboring gene STARR-seq mESC enhancer starr_38517 Neighboring gene STARR-seq mESC enhancer starr_38518 Neighboring gene STARR-seq mESC enhancer starr_38519 Neighboring gene predicted gene, 33557

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables RNA polymerase II-specific DNA-binding transcription factor binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables RNA polymerase II-specific DNA-binding transcription factor binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables transcription coactivator activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables transcription coactivator activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables transcription corepressor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables transcription corepressor activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in anatomical structure morphogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in atrioventricular valve morphogenesis TAS
    Traceable Author Statement
    more info
    PubMed 
    acts_upstream_of_or_within cardiac muscle tissue development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in cardiac muscle tissue morphogenesis TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in cell differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within embryonic organ development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within embryonic organ development ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    involved_in fat cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in fat cell differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in heart development IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within heart development IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within heart development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within in utero embryonic development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within lung development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in mitral valve formation TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in negative regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of DNA-templated transcription TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in negative regulation of fat cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of female gonad development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in outflow tract morphogenesis TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in outflow tract septum morphogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in outflow tract septum morphogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of DNA-templated transcription IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of DNA-templated transcription TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in positive regulation of cardiac muscle cell proliferation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in positive regulation of macromolecule biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of male gonad development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in right ventricular cardiac muscle tissue morphogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in right ventricular cardiac muscle tissue morphogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in tricuspid valve formation TAS
    Traceable Author Statement
    more info
    PubMed 
    acts_upstream_of_or_within vasculogenesis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within vasculogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in vasculogenesis involved in coronary vascular morphogenesis TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in ventricular septum morphogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in ventricular septum morphogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in male germ cell nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    zinc finger protein ZFPM2
    Names
    Friend of GATA 2
    friend of GATA protein 2
    friend of GATA-1 2
    friend of GATA-2
    mFOG-2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001356998.1NP_001343927.1  zinc finger protein ZFPM2 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC101996, AC102004, AC158556, AC163008
      UniProtKB/TrEMBL
      A5HE91
      Related
      ENSMUSP00000155094.2, ENSMUST00000230319.2
      Conserved Domains (2) summary
      sd00017
      Location:248267
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam15909
      Location:245349
      zf-C2H2_8; C2H2-type zinc ribbon
    2. NM_011766.5NP_035896.1  zinc finger protein ZFPM2 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC101996, AC102004, AC158556, AC163008
      Consensus CDS
      CCDS27447.1
      UniProtKB/Swiss-Prot
      Q8CCH7, Q9Z0F2
      UniProtKB/TrEMBL
      A5HE91
      Related
      ENSMUSP00000051335.5, ENSMUST00000053467.6
      Conserved Domains (2) summary
      sd00017
      Location:301320
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam15909
      Location:298388
      zf-C2H2_8; C2H2-type zinc ribbon

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000081.7 Reference GRCm39 C57BL/6J

      Range
      40518438..40967988
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)