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    Abra actin-binding Rho activating protein [ Mus musculus (house mouse) ]

    Gene ID: 223513, updated on 9-Dec-2024

    Summary

    Official Symbol
    Abraprovided by MGI
    Official Full Name
    actin-binding Rho activating proteinprovided by MGI
    Primary source
    MGI:MGI:2444891
    See related
    Ensembl:ENSMUSG00000042895 AllianceGenome:MGI:2444891
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    STARS; C130068O12Rik
    Summary
    Enables actin binding activity. Involved in actin cytoskeleton organization and positive regulation of Rho protein signal transduction. Acts upstream of or within positive regulation of transcription by RNA polymerase II and protein import into nucleus. Located in actin cytoskeleton and myofibril. Is expressed in embryo; heart; hindlimb muscle; and skeletal muscle. Orthologous to human ABRA (actin binding Rho activating protein). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in heart adult (RPKM 5.2), mammary gland adult (RPKM 1.9) and 3 other tissues See more
    Orthologs
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    Genomic context

    See Abra in Genome Data Viewer
    Location:
    15 B3.1; 15 16.42 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (41728689..41733116, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (41865293..41869720, complement)

    Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_38520 Neighboring gene predicted gene, 41312 Neighboring gene STARR-seq mESC enhancer starr_38522 Neighboring gene STARR-seq mESC enhancer starr_38523 Neighboring gene STARR-seq mESC enhancer starr_38524 Neighboring gene STARR-seq mESC enhancer starr_38525 Neighboring gene oxidation resistance 1 Neighboring gene STARR-seq mESC enhancer starr_38527 Neighboring gene STARR-seq mESC enhancer starr_38528 Neighboring gene STARR-positive B cell enhancer ABC_E10851 Neighboring gene STARR-seq mESC enhancer starr_38530 Neighboring gene STARR-seq mESC enhancer starr_38531 Neighboring gene STARR-seq mESC enhancer starr_38533 Neighboring gene predicted gene, 26854 Neighboring gene STARR-positive B cell enhancer mm9_chr15:41650297-41650598 Neighboring gene STARR-positive B cell enhancer ABC_E7365 Neighboring gene STARR-seq mESC enhancer starr_38536 Neighboring gene STARR-seq mESC enhancer starr_38537 Neighboring gene STARR-seq mESC enhancer starr_38538 Neighboring gene heterogeneous nuclear ribonucleoprotein A3 pseudogene Neighboring gene predicted gene, 24751

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (1)  1 citation

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables actin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in actin cytoskeleton IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in myofibril IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in sarcomere IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in sarcomere ISO
    Inferred from Sequence Orthology
    more info
     
    located_in sarcomere ISS
    Inferred from Sequence or Structural Similarity
    more info
     

    General protein information

    Preferred Names
    actin-binding Rho-activating protein
    Names
    striated muscle activator of Rho-dependent signaling

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_175456.4NP_780665.1  actin-binding Rho-activating protein

      See identical proteins and their annotated locations for NP_780665.1

      Status: PROVISIONAL

      Source sequence(s)
      AC129212
      Consensus CDS
      CCDS27449.1
      UniProtKB/Swiss-Prot
      Q0VB05, Q3UU01, Q8BLH3, Q8BUZ1, Q8K431
      Related
      ENSMUSP00000051973.6, ENSMUST00000054742.7
      Conserved Domains (1) summary
      pfam14705
      Location:299373
      Costars; Costars

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000081.7 Reference GRCm39 C57BL/6J

      Range
      41728689..41733116 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)