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    Rrp1b ribosomal RNA processing 1B [ Mus musculus (house mouse) ]

    Gene ID: 72462, updated on 9-Dec-2024

    Summary

    Official Symbol
    Rrp1bprovided by MGI
    Official Full Name
    ribosomal RNA processing 1Bprovided by MGI
    Primary source
    MGI:MGI:1919712
    See related
    Ensembl:ENSMUSG00000058392 AllianceGenome:MGI:1919712
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Kiaa0179; mKIAA0179; D030064A17; 2600005C20Rik
    Summary
    Predicted to enable transcription coactivator activity. Involved in negative regulation of GTPase activity and regulation of RNA splicing. Located in euchromatin; heterochromatin; and nucleus. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; sensory organ; and sternum. Orthologous to human RRP1B (ribosomal RNA processing 1B). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 6.4), limb E14.5 (RPKM 6.2) and 28 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Rrp1b in Genome Data Viewer
    Location:
    17 B1; 17 17.34 cM
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (32255087..32281839)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (32036162..32062865)

    Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 30571 Neighboring gene STARR-seq mESC enhancer starr_42364 Neighboring gene heat shock transcription factor 2 binding protein Neighboring gene STARR-seq mESC enhancer starr_42366 Neighboring gene pyridoxal (pyridoxine, vitamin B6) kinase, pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E4204 Neighboring gene predicted gene, 30729

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 
    • Targeted (2) 

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables transcription coactivator activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables transcription coactivator activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Process Evidence Code Pubs
    involved_in RNA splicing IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular response to virus IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular response to virus ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in mRNA processing IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of GTPase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation by host of viral transcription IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation by host of viral transcription ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of apoptotic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of transcription by RNA polymerase II ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in rRNA processing IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of RNA splicing IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in chromosome ISO
    Inferred from Sequence Orthology
    more info
     
    located_in euchromatin IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in granular component ISO
    Inferred from Sequence Orthology
    more info
     
    located_in granular component ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in heterochromatin IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleolus ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of preribosome, small subunit precursor IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    ribosomal RNA processing protein 1 homolog B
    Names
    RRP1-like protein B
    ribosomal RNA processing 1 homolog B

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001163734.1NP_001157206.1  ribosomal RNA processing protein 1 homolog B isoform 2

      See identical proteins and their annotated locations for NP_001157206.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (2) is shorter at the N-terminus compared to isoform 1.
      Source sequence(s)
      CT033797
      UniProtKB/TrEMBL
      Q6ZQH4
      Related
      ENSMUST00000147076.8
      Conserved Domains (2) summary
      pfam06070
      Location:301617
      Herpes_UL32; Herpesvirus large structural phosphoprotein UL32
      pfam05997
      Location:1117
      Nop52; Nucleolar protein,Nop52
    2. NM_028244.2NP_082520.2  ribosomal RNA processing protein 1 homolog B isoform 1

      See identical proteins and their annotated locations for NP_082520.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      CT033797
      Consensus CDS
      CCDS28613.1
      UniProtKB/Swiss-Prot
      B0V2W7, Q91YK2
      UniProtKB/TrEMBL
      Q6ZQH4
      Related
      ENSMUSP00000080085.7, ENSMUST00000081339.13
      Conserved Domains (1) summary
      pfam05997
      Location:11218
      Nop52; Nucleolar protein,Nop52

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000083.7 Reference GRCm39 C57BL/6J

      Range
      32255087..32281839
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036160793.1XP_036016686.1  ribosomal RNA processing protein 1 homolog B isoform X2

      UniProtKB/TrEMBL
      Q6ZQH4
      Conserved Domains (1) summary
      pfam05997
      Location:20145
      Nop52; Nucleolar protein,Nop52
    2. XM_006524971.3XP_006525034.1  ribosomal RNA processing protein 1 homolog B isoform X1

      UniProtKB/TrEMBL
      Q6ZQH4
      Conserved Domains (2) summary
      pfam06070
      Location:332648
      Herpes_UL32; Herpesvirus large structural phosphoprotein UL32
      pfam05997
      Location:2148
      Nop52; Nucleolar protein,Nop52
    3. XM_006524972.3XP_006525035.1  ribosomal RNA processing protein 1 homolog B isoform X3

      See identical proteins and their annotated locations for XP_006525035.1

      UniProtKB/TrEMBL
      Q6ZQH4
      Conserved Domains (2) summary
      pfam06070
      Location:301617
      Herpes_UL32; Herpesvirus large structural phosphoprotein UL32
      pfam05997
      Location:1117
      Nop52; Nucleolar protein,Nop52

    RNA

    1. XR_001782117.3 RNA Sequence

    2. XR_003952190.2 RNA Sequence

    3. XR_003952191.2 RNA Sequence