Ppa2 pyrophosphatase (inorganic) 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Ppa2provided by MGI
Official Full Name: pyrophosphatase (inorganic) 2provided by MGI
Primary source: MGI:MGI:1922026
See related: Ensembl:ENSMUSG00000028013 AllianceGenome:MGI:1922026
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Sid6306; 1110013G13Rik
Summary: Enables protein serine/threonine phosphatase activity. Predicted to be involved in diphosphate metabolic process; phosphate-containing compound metabolic process; and regulation of mitochondrial membrane potential. Located in mitochondrion. Is active in synapse. Orthologous to human PPA2 (inorganic pyrophosphatase 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in adrenal adult (RPKM 80.8), kidney adult (RPKM 69.5) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 3 G3; 3 61.71 cM

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	3	NC_000069.7 (133015842..133083996)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	3	NC_000069.6 (133310059..133378235)

Chromosome 3 - NC_000069.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

downregulation of protein phosphatase 2 activity in PINK1-silenced cells promotes the protective effect of autophagy through phosphorylation of Bcl-2
Title: Loss of PINK1 function decreases PP2A activity and promotes autophagy in dopaminergic cells and a murine model.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Gene trapped (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables inorganic diphosphate phosphatase activity	IBA Inferred from Biological aspect of Ancestor more info
enables inorganic diphosphate phosphatase activity	ISO Inferred from Sequence Orthology more info
enables inorganic diphosphate phosphatase activity	ISS Inferred from Sequence or Structural Similarity more info
enables magnesium ion binding	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine phosphatase activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in diphosphate metabolic process	ISO Inferred from Sequence Orthology more info
involved_in diphosphate metabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in phosphate-containing compound metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in phosphate-containing compound metabolic process	IEA Inferred from Electronic Annotation more info
involved_in regulation of mitochondrial membrane potential	IEA Inferred from Electronic Annotation more info
involved_in regulation of mitochondrial membrane potential	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in mitochondrion	HDA more info	PubMed
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info
is_active_in synapse	EXP Inferred from Experiment more info	PubMed
is_active_in synapse	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: inorganic pyrophosphatase 2, mitochondrial

Names: PPase 2; pyrophosphate phospho-hydrolase 2

NP_001280570.1

EC 3.6.1.1

NP_666253.1

EC 3.6.1.1

XP_006502279.1

EC 3.6.1.1

XP_006502280.1

EC 3.6.1.1

XP_030108717.1

EC 3.6.1.1

XP_030108718.1

EC 3.6.1.1

XP_036019259.1

EC 3.6.1.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001293641.1 → NP_001280570.1 inorganic pyrophosphatase 2, mitochondrial isoform 2 precursor

Status: VALIDATED

Description

Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 3' coding region compared to variant 1. The encoded isoform (2) is shorter than isoform 1.

Source sequence(s)

AA444705, AC125040, AK090384

Consensus CDS

CCDS80024.1

UniProtKB/TrEMBL

D3Z636

Related

ENSMUSP00000113369.2, ENSMUST00000122334.8

Conserved Domains (1) summary

cl00217
Location:3 → 284

pyrophosphatase; Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers.
NM_146141.2 → NP_666253.1 inorganic pyrophosphatase 2, mitochondrial isoform 1 precursor

See identical proteins and their annotated locations for NP_666253.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).

Source sequence(s)

AA444705, AK090384, AK143475

Consensus CDS

CCDS17850.1

UniProtKB/Swiss-Prot

Q3UPK3, Q8BTG5, Q91VM9, Q9D1E3

Related

ENSMUSP00000029644.10, ENSMUST00000029644.16

Conserved Domains (1) summary

cl00217
Location:3 → 284

pyrophosphatase; Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers.

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000069.7 Reference GRCm39 C57BL/6J

Range

133015842..133083996

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036163366.1 → XP_036019259.1 inorganic pyrophosphatase 2, mitochondrial isoform X1
XM_006502216.5 → XP_006502279.1 inorganic pyrophosphatase 2, mitochondrial isoform X2

Conserved Domains (1) summary

cl00217
Location:3 → 226

pyrophosphatase; Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers.
XM_030252857.2 → XP_030108717.1 inorganic pyrophosphatase 2, mitochondrial isoform X3

Conserved Domains (1) summary

cl00217
Location:3 → 226

pyrophosphatase; Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers.
XM_006502217.5 → XP_006502280.1 inorganic pyrophosphatase 2, mitochondrial isoform X4

Conserved Domains (1) summary

cl00217
Location:26 → 167

pyrophosphatase; Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers.
XM_030252858.2 → XP_030108718.1 inorganic pyrophosphatase 2, mitochondrial isoform X5

Conserved Domains (1) summary

cl00217
Location:26 → 167

pyrophosphatase; Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers.