Morn3 MORN repeat containing 3 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Morn3provided by MGI
Official Full Name: MORN repeat containing 3provided by MGI
Primary source: MGI:MGI:1922140
See related: Ensembl:ENSMUSG00000029477 AllianceGenome:MGI:1922140
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 4930438O03Rik
Summary: Predicted to enable protein-macromolecule adaptor activity. Predicted to be involved in negative regulation of signal transduction by p53 class mediator. Predicted to be located in acrosomal vesicle. Is expressed in lung. Orthologous to human MORN3 (MORN repeat containing 3). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Restricted expression toward testis adult (RPKM 68.5) See more
Orthologs: human all
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Genomic context

Location:: 5 F; 5 62.73 cM

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	5	NC_000071.7 (123171462..123185099, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	5	NC_000071.6 (123033440..123047036, complement)

Chromosome 5 - NC_000071.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

MORN3 is another regulator for spermatogenesis, probably together with MEIG1.
Title: Characterization of membrane occupation and recognition nexus repeat containing 3, meiosis expressed gene 1 binding partner, in mouse male germ cells.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (4) 1 citation

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables molecular_function	ND No biological Data available more info
enables protein-macromolecule adaptor activity	IEA Inferred from Electronic Annotation more info
enables protein-macromolecule adaptor activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in biological_process	ND No biological Data available more info
involved_in negative regulation of signal transduction by p53 class mediator	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of signal transduction by p53 class mediator	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in acrosomal vesicle	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: MORN repeat-containing protein 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001347456.1 → NP_001334385.1 MORN repeat-containing protein 3 isoform 2

Status: VALIDATED

Description

Transcript Variant: This variant (2) lacks an alternate coding exon compared to variant 1, that causes a frameshift. The resulting isoform (2) has a shorter and distinct C-terminus compared to isoform 1.

Source sequence(s)

AC121564, AC158114

Consensus CDS

CCDS84956.1

UniProtKB/Swiss-Prot

Q8C5T4

Related

ENSMUSP00000041714.9, ENSMUST00000045843.15

Conserved Domains (1) summary

PLN03185
Location:34 → 150

PLN03185; phosphatidylinositol phosphate kinase; Provisional
NM_029112.2 → NP_083388.1 MORN repeat-containing protein 3 isoform 1

See identical proteins and their annotated locations for NP_083388.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (1).

Source sequence(s)

AC121564, AC158114

Consensus CDS

CCDS19659.1

UniProtKB/Swiss-Prot

Q8C5T4, Q8VE21, Q9D5H6

Related

ENSMUSP00000031437.8, ENSMUST00000031437.14

Conserved Domains (1) summary

PLN03185
Location:34 → 190

PLN03185; phosphatidylinositol phosphate kinase; Provisional

RNA

NR_153115.1 RNA Sequence

Status: VALIDATED

Description

Transcript Variant: This variant (3) lacks an alternate internal exon and differs in the 3' end compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).

Source sequence(s)

AK077141