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    Pou2f3 POU domain, class 2, transcription factor 3 [ Mus musculus (house mouse) ]

    Gene ID: 18988, updated on 9-Dec-2024

    Summary

    Official Symbol
    Pou2f3provided by MGI
    Official Full Name
    POU domain, class 2, transcription factor 3provided by MGI
    Primary source
    MGI:MGI:102565
    See related
    Ensembl:ENSMUSG00000032015 AllianceGenome:MGI:102565
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Skin; Oct11; Otf11; Epoc-1; Otf-11; Skn-1a; Skn-li; Oct-11a; Skin-1a
    Summary
    Enables identical protein binding activity and sequence-specific DNA binding activity. Involved in cell differentiation. Acts upstream of or within keratinocyte differentiation; positive regulation of transcription by RNA polymerase II; and wound healing. Located in nucleus. Part of transcription regulator complex. Is expressed in several structures, including early conceptus; genitourinary system; gut; skin; and thymus. Orthologous to human POU2F3 (POU class 2 homeobox 3). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in limb E14.5 (RPKM 2.0), placenta adult (RPKM 1.8) and 11 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Pou2f3 in Genome Data Viewer
    Location:
    9 A5.1; 9 24.21 cM
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (43035222..43117052, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (43123927..43205755, complement)

    Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene Rho guanine nucleotide exchange factor 12 Neighboring gene STARR-seq mESC enhancer starr_23915 Neighboring gene Sp140 nuclear body protein family member pseudogene Neighboring gene STARR-seq mESC enhancer starr_23916 Neighboring gene TLC domain containing 5 Neighboring gene STARR-seq mESC enhancer starr_23926 Neighboring gene ribosomal protein L26, pseudogene 6 Neighboring gene out at first homolog

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Component Evidence Code Pubs
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nuclear body IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nuclear body ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleolus IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    part_of transcription regulator complex IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    POU domain, class 2, transcription factor 3
    Names
    oct-11
    octamer-binding protein 11
    octamer-binding transcription factor 11

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_011139.2NP_035269.2  POU domain, class 2, transcription factor 3

      See identical proteins and their annotated locations for NP_035269.2

      Status: VALIDATED

      Source sequence(s)
      AC110169, AC173346, AK153697
      Consensus CDS
      CCDS40596.1
      UniProtKB/Swiss-Prot
      H3BJT4, P31362
      Related
      ENSMUSP00000135115.2, ENSMUST00000176636.5
      Conserved Domains (2) summary
      smart00352
      Location:176250
      POU; Found in Pit-Oct-Unc transcription factors
      pfam00046
      Location:277330
      Homeobox; Homeobox domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000075.7 Reference GRCm39 C57BL/6J

      Range
      43035222..43117052 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011242420.3XP_011240722.1  POU domain, class 2, transcription factor 3 isoform X1

      See identical proteins and their annotated locations for XP_011240722.1

      UniProtKB/TrEMBL
      G3X913, Q3U5D1
      Related
      ENSMUSP00000034513.6, ENSMUST00000034513.13
      Conserved Domains (3) summary
      smart00352
      Location:164238
      POU; Found in Pit-Oct-Unc transcription factors
      pfam00046
      Location:265319
      Homeobox; Homeobox domain
      pfam09770
      Location:39151
      PAT1; Topoisomerase II-associated protein PAT1