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    LPAR5 lysophosphatidic acid receptor 5 [ Homo sapiens (human) ]

    Gene ID: 57121, updated on 10-Dec-2024

    Summary

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    Official Symbol
    LPAR5provided by HGNC
    Official Full Name
    lysophosphatidic acid receptor 5provided by HGNC
    Primary source
    HGNC:HGNC:13307
    See related
    Ensembl:ENSG00000184574 MIM:606926; AllianceGenome:HGNC:13307
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    LPA5; GPR92; GPR93; KPG_010
    Summary
    This gene encodes a member of the rhodopsin class of G protein-coupled transmembrane receptors. This protein transmits extracellular signals from lysophosphatidic acid to cells through heterotrimeric G proteins and mediates numerous cellular processes. Many G protein receptors serve as targets for pharmaceutical drugs. Transcript variants of this gene have been described.[provided by RefSeq, Dec 2008]
    Expression
    Broad expression in colon (RPKM 5.6), lymph node (RPKM 4.4) and 23 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See LPAR5 in Genome Data Viewer
    Location:
    12p13.31
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 12 NC_000012.12 (6618835..6635959, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 12 NC_060936.1 (6629192..6646324, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (6728001..6745125, complement)

    Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene chromodomain helicase DNA binding protein 4 Neighboring gene small Cajal body-specific RNA 11 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:6705357-6705858 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:6705859-6706358 Neighboring gene uncharacterized LOC124902867 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5868 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4172 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4173 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4174 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5869 Neighboring gene CRISPRi-validated cis-regulatory element chr12.325 Neighboring gene uncharacterized LOC105369631 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:6729027-6729548 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:6729549-6730069 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5870 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5871 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4176 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5872 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:6756019-6756532 Neighboring gene acrosin binding protein Neighboring gene MPRA-validated peak1551 silencer Neighboring gene inhibitor of growth family member 4 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5874

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Emerging roles of lysophosphatidic acid receptor subtype 5 (LPAR5) in inflammatory diseases and cancer. Dacheux MA, et al. Pharmacol Ther, 2023 May. PMID 37061203, Free PMC Article
    2. Unique ligand selectivity of the GPR92/LPA5 lysophosphatidate receptor indicates role in human platelet activation. Williams JR, et al. J Biol Chem, 2009 Jun 19. PMID 19366702, Free PMC Article
    3. Lysophosphatidic acid receptor-5 negatively regulates cell motile and invasive activities of human sarcoma cell lines. Dong Y, et al. Mol Cell Biochem, 2014 Aug. PMID 24676544
    4. Down-regulation of LPA receptor 5 contributes to aberrant LPA signalling in EBV-associated nasopharyngeal carcinoma. Yap LF, et al. J Pathol, 2015 Feb. PMID 25294670
    5. Involvement of LPA receptor-5 in the enhancement of cell motile activity by phorbol ester and anticancer drug treatments in melanoma A375 cells. Fukushima K, et al. Biochem Biophys Res Commun, 2018 Jan 29. PMID 29309788

    See all (40) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Crosstalk between cannabinoid receptor 2 and lysophosphatidic acid receptor 5.
      Title: Crosstalk between cannabinoid receptor 2 and lysophosphatidic acid receptor 5.
    2. Emerging roles of lysophosphatidic acid receptor subtype 5 (LPAR5) in inflammatory diseases and cancer.
      Title: Emerging roles of lysophosphatidic acid receptor subtype 5 (LPAR5) in inflammatory diseases and cancer.
    3. Potential role of LPAR5 gene in prognosis and immunity of thyroid papillary carcinoma and pan-cancer.
      Title: Potential role of LPAR5 gene in prognosis and immunity of thyroid papillary carcinoma and pan-cancer.
    4. Infiltration of LPAR5[+] macrophages in osteosarcoma tumor microenvironment predicts better outcomes.
      Title: Infiltration of LPAR5(+) macrophages in osteosarcoma tumor microenvironment predicts better outcomes.
    5. LPAR5 confers radioresistance to cancer cells associated with EMT activation via the ERK/Snail pathway.
      Title: LPAR5 confers radioresistance to cancer cells associated with EMT activation via the ERK/Snail pathway.
    6. Control of Intestinal Epithelial Permeability by Lysophosphatidic Acid Receptor 5.
      Title: Control of Intestinal Epithelial Permeability by Lysophosphatidic Acid Receptor 5.
    7. Lysophosphatidic acid mediates the pathogenesis of psoriasis by activating keratinocytes through LPAR5.
      Title: Lysophosphatidic acid mediates the pathogenesis of psoriasis by activating keratinocytes through LPAR5.
    8. Interference with lysophosphatidic acid receptor 5 ameliorates oxidized low-density lipoprotein-induced human umbilical vein endothelial cell injury by inactivating NOD-like receptor family, pyrin domain containing 3 inflammasome signaling.
      Title: Interference with lysophosphatidic acid receptor 5 ameliorates oxidized low-density lipoprotein-induced human umbilical vein endothelial cell injury by inactivating NOD-like receptor family, pyrin domain containing 3 inflammasome signaling.
    9. LPAR5 stimulates the malignant progression of non-small-cell lung carcinoma by upregulating MLLT11.
      Title: LPAR5 stimulates the malignant progression of non-small-cell lung carcinoma by upregulating MLLT11.
    10. LPAR5 promotes thyroid carcinoma cell proliferation and migration by activating class IA PI3K catalytic subunit p110beta.
      Title: LPAR5 promotes thyroid carcinoma cell proliferation and migration by activating class IA PI3K catalytic subunit p110β.
    Submit: New GeneRIF Correction See all GeneRIFs (28)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Potential readthrough

    Included gene: ACRBP

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables G protein-coupled receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in behavioral response to pain IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
    		  

    General protein information

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    Preferred Names
    lysophosphatidic acid receptor 5
    Names
    G protein-coupled receptor 92
    G-protein coupled receptor 93
    LPA receptor 5
    LPA-5

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001142961.1 → NP_001136433.1  lysophosphatidic acid receptor 5

      See identical proteins and their annotated locations for NP_001136433.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      BC072394, DC328599
      Consensus CDS
      CCDS8553.1
      UniProtKB/Swiss-Prot
      Q9H1C0
      UniProtKB/TrEMBL
      B4DZ78, Q5KU18
      Related
      ENSP00000393098.1, ENST00000431922.1
      Conserved Domains (2) summary
      cd14964
      Location:25 → 49
      7tm_GPCRs; TM helix 1 [structural motif]
      cl28897
      Location:23 → 308
      7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

    2. NM_020400.6 → NP_065133.1  lysophosphatidic acid receptor 5

      See identical proteins and their annotated locations for NP_065133.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      BC072394
      Consensus CDS
      CCDS8553.1
      UniProtKB/Swiss-Prot
      Q9H1C0
      UniProtKB/TrEMBL
      B4DZ78, Q5KU18
      Related
      ENSP00000327875.4, ENST00000329858.9
      Conserved Domains (2) summary
      cd14964
      Location:25 → 49
      7tm_GPCRs; TM helix 1 [structural motif]
      cl28897
      Location:23 → 308
      7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000012.12 Reference GRCh38.p14 Primary Assembly

      Range
      6618835..6635959 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060936.1 Alternate T2T-CHM13v2.0

      Range
      6629192..6646324 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9H1C0.1 GenPept UniProtKB/Swiss-Prot:Q9H1C0

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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