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    MYO10 myosin X [ Homo sapiens (human) ]

    Gene ID: 4651, updated on 4-Jan-2025

    Summary

    Official Symbol
    MYO10provided by HGNC
    Official Full Name
    myosin Xprovided by HGNC
    Primary source
    HGNC:HGNC:7593
    See related
    Ensembl:ENSG00000145555 MIM:601481; AllianceGenome:HGNC:7593
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    MyoX
    Summary
    This gene encodes a member of the myosin superfamily. The protein represents an unconventional myosin; it should not be confused with the conventional non-muscle myosin-10 (MYH10). Unconventional myosins contain the basic domains of conventional myosins and are further distinguished from class members by their tail domains. This gene functions as an actin-based molecular motor and plays a role in integration of F-actin and microtubule cytoskeletons during meiosis. [provided by RefSeq, Dec 2011]
    Expression
    Broad expression in brain (RPKM 12.7), thyroid (RPKM 12.2) and 23 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See MYO10 in Genome Data Viewer
    Location:
    5p15.1
    Exon count:
    44
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 5 NC_000005.10 (16661907..16936288, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 5 NC_060929.1 (16601148..16875413, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (16662016..16936397, complement)

    Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22421 Neighboring gene ReSE screen-validated silencer GRCh37_chr5:16467094-16467316 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22422 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22423 Neighboring gene zinc finger protein 622 Neighboring gene reticulophagy regulator 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:16535515-16536016 Neighboring gene Sharpr-MPRA regulatory region 7449 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr5:16575232-16575796 Neighboring gene ReSE screen-validated silencer GRCh37_chr5:16606665-16606881 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15947 Neighboring gene RETREG1 antisense RNA 1 Neighboring gene Sharpr-MPRA regulatory region 7757 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:16711171-16711672 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:16718131-16718712 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr5:16721745-16722434 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:16741941-16742846 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr5:16741036-16741940 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr5:16754668-16755308 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:16755309-16755949 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:16794335-16794862 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:16794863-16795390 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:16805998-16806498 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:16806499-16806999 Neighboring gene H3K27ac hESC enhancer GRCh37_chr5:16809483-16809982 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:16829693-16830613 Neighboring gene RNA, 5S ribosomal pseudogene 179 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_83741 Neighboring gene H3K27ac hESC enhancer GRCh37_chr5:16897552-16898412 Neighboring gene ribosomal protein S26 pseudogene 28 Neighboring gene ReSE screen-validated silencer GRCh37_chr5:16951303-16951587 Neighboring gene RNA, U6 small nuclear 660, pseudogene Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr5:16994519-16995071 Neighboring gene NANOG hESC enhancer GRCh37_chr5:17066008-17066589 Neighboring gene uncharacterized LOC124900947 Neighboring gene Sharpr-MPRA regulatory region 7707

    Genomic regions, transcripts, and products

    Expression

    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    BioGRID CRISPR Screen Phenotypes (33 hits/1270 screens)

    EBI GWAS Catalog

    Description
    Common genetic variation and antidepressant efficacy in major depressive disorder: a meta-analysis of three genome-wide pharmacogenetic studies.
    EBI GWAS Catalog
    Genome-wide association analyses suggest NELL1 influences adverse metabolic response to HCTZ in African Americans.
    EBI GWAS Catalog
    Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
    EBI GWAS Catalog

    Pathways from PubChem

    Interactions

    General gene information

    Clone Names

    • FLJ10639, FLJ21066, FLJ22268, FLJ43256, KIAA0799, MGC131988

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables ATP binding  
    enables actin filament binding  
    enables actin filament binding  
    enables calmodulin binding  
    enables microfilament motor activity  
    enables phosphatidylinositol-3,4,5-trisphosphate binding  
    enables phosphatidylinositol-3,4,5-trisphosphate binding  
    enables plus-end directed microfilament motor activity  
    enables plus-end directed microfilament motor activity  
    enables protein binding PubMed 
    enables spectrin binding PubMed 
    Process Evidence Code Pubs
    involved_in cytoskeleton-dependent intracellular transport  
    involved_in cytoskeleton-dependent intracellular transport  
    involved_in positive regulation of cell-cell adhesion  
    involved_in regulation of cell shape  
    involved_in regulation of cell shape PubMed 
    involved_in regulation of filopodium assembly  
    involved_in regulation of filopodium assembly PubMed 
    involved_in signal transduction  
    Component Evidence Code Pubs
    located_in cell cortex  
    located_in cytosol  
    located_in cytosol  
    is_active_in filopodium  
    located_in filopodium membrane  
    located_in filopodium tip  
    located_in lamellipodium  
    part_of myosin complex  
    located_in neuron projection  
    located_in neuronal cell body  
    located_in nucleolus  
    located_in plasma membrane  
    located_in ruffle  

    General protein information

    Preferred Names
    unconventional myosin-X
    Names
    unconventional myosin-10
    unconventionnal myosin-X

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_012334.3 → NP_036466.2  unconventional myosin-X

      See identical proteins and their annotated locations for NP_036466.2

      Status: REVIEWED

      Source sequence(s)
      AC010607, AC024588, AF234532, AI086647, BC014956, BC150285, CA488271, DA504301
      Consensus CDS
      CCDS54834.1
      UniProtKB/Swiss-Prot
      A7E2D1, O94893, Q8IVX5, Q9HD67, Q9NYM7, Q9P110, Q9P111, Q9UHF6
      UniProtKB/TrEMBL
      A0A0A0MQX1
      Related
      ENSP00000421280.1, ENST00000513610.6
      Conserved Domains (12) summary
      smart00139
      Location:1549 → 1695
      MyTH4; Domain in Myosin and Kinesin Tails
      smart00242
      Location:58 → 739
      MYSc; Myosin. Large ATPases
      smart00295
      Location:1704 → 1958
      B41; Band 4.1 homologues
      cd13202
      Location:1954 → 2042
      FERM_C_MyoX; FERM domain C-lobe of Myosin X (MyoX, Myo10)
      cd13296
      Location:1215 → 1316
      PH2_MyoX; Myosin X Pleckstrin homology (PH) domain, repeat 2
      cd13297
      Location:1381 → 1506
      PH3_MyoX-like; Myosin X-like Pleckstrin homology (PH) domain, repeat 3
      cd14873
      Location:77 → 727
      MYSc_Myo10; class X myosin, motor domain
      pfam00169
      Location:1215 → 1308
      PH; PH domain
      pfam00373
      Location:1796 → 1958
      FERM_M; FERM central domain
      pfam16735
      Location:883 → 933
      MYO10_CC; Unconventional myosin-X coiled coil domain
      cl00155
      Location:1705 → 1753
      UBQ; Ubiquitin-like proteins
      cl17171
      Location:1181 → 1223
      PH-like; Pleckstrin homology-like domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000005.10 Reference GRCh38.p14 Primary Assembly

      Range
      16661907..16936288 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006714475.4 → XP_006714538.1  unconventional myosin-X isoform X1

      UniProtKB/TrEMBL
      A0A0A0MQX1
      Conserved Domains (12) summary
      smart00139
      Location:1526 → 1672
      MyTH4; Domain in Myosin and Kinesin Tails
      smart00242
      Location:58 → 716
      MYSc; Myosin. Large ATPases
      smart00295
      Location:1681 → 1935
      B41; Band 4.1 homologues
      cd13202
      Location:1931 → 2019
      FERM_C_MyoX; FERM domain C-lobe of Myosin X (MyoX, Myo10)
      cd13296
      Location:1192 → 1293
      PH2_MyoX; Myosin X Pleckstrin homology (PH) domain, repeat 2
      cd13297
      Location:1358 → 1483
      PH3_MyoX-like; Myosin X-like Pleckstrin homology (PH) domain, repeat 3
      cd14873
      Location:77 → 704
      MYSc_Myo10; class X myosin, motor domain
      pfam00169
      Location:1192 → 1285
      PH; PH domain
      pfam00373
      Location:1773 → 1935
      FERM_M; FERM central domain
      pfam16735
      Location:860 → 910
      MYO10_CC; Unconventional myosin-X coiled coil domain
      cl00155
      Location:1682 → 1730
      UBQ; Ubiquitin-like proteins
      cl17171
      Location:1158 → 1200
      PH-like; Pleckstrin homology-like domain
    2. XM_005248307.3 → XP_005248364.1  unconventional myosin-X isoform X3

      See identical proteins and their annotated locations for XP_005248364.1

      UniProtKB/TrEMBL
      B7ZA23
      Related
      ENSP00000421170.1, ENST00000505695.5
      Conserved Domains (11) summary
      smart00139
      Location:906 → 1052
      MyTH4; Domain in Myosin and Kinesin Tails
      smart00295
      Location:1061 → 1315
      B41; Band 4.1 homologues
      cd13202
      Location:1311 → 1399
      FERM_C_MyoX; FERM domain C-lobe of Myosin X (MyoX, Myo10)
      cd13296
      Location:572 → 673
      PH2_MyoX; Myosin X Pleckstrin homology (PH) domain, repeat 2
      cd13297
      Location:738 → 863
      PH3_MyoX-like; Myosin X-like Pleckstrin homology (PH) domain, repeat 3
      cl22853
      Location:1 → 84
      Motor_domain; Myosin and Kinesin motor domain
      pfam00169
      Location:572 → 665
      PH; PH domain
      pfam00373
      Location:1153 → 1315
      FERM_M; FERM central domain
      pfam16735
      Location:240 → 290
      MYO10_CC; Unconventional myosin-X coiled coil domain
      cl00155
      Location:1062 → 1110
      UBQ; Ubiquitin-like proteins
      cl17171
      Location:538 → 580
      PH-like; Pleckstrin homology-like domain
    3. XM_011514046.3 → XP_011512348.1  unconventional myosin-X isoform X3

      See identical proteins and their annotated locations for XP_011512348.1

      UniProtKB/TrEMBL
      B7ZA23
      Related
      ENSP00000425051.1, ENST00000515803.5
      Conserved Domains (11) summary
      smart00139
      Location:906 → 1052
      MyTH4; Domain in Myosin and Kinesin Tails
      smart00295
      Location:1061 → 1315
      B41; Band 4.1 homologues
      cd13202
      Location:1311 → 1399
      FERM_C_MyoX; FERM domain C-lobe of Myosin X (MyoX, Myo10)
      cd13296
      Location:572 → 673
      PH2_MyoX; Myosin X Pleckstrin homology (PH) domain, repeat 2
      cd13297
      Location:738 → 863
      PH3_MyoX-like; Myosin X-like Pleckstrin homology (PH) domain, repeat 3
      cl22853
      Location:1 → 84
      Motor_domain; Myosin and Kinesin motor domain
      pfam00169
      Location:572 → 665
      PH; PH domain
      pfam00373
      Location:1153 → 1315
      FERM_M; FERM central domain
      pfam16735
      Location:240 → 290
      MYO10_CC; Unconventional myosin-X coiled coil domain
      cl00155
      Location:1062 → 1110
      UBQ; Ubiquitin-like proteins
      cl17171
      Location:538 → 580
      PH-like; Pleckstrin homology-like domain
    4. XM_005248306.5 → XP_005248363.1  unconventional myosin-X isoform X2

      UniProtKB/TrEMBL
      B7ZA23
      Conserved Domains (11) summary
      smart00139
      Location:907 → 1053
      MyTH4; Domain in Myosin and Kinesin Tails
      smart00295
      Location:1062 → 1316
      B41; Band 4.1 homologues
      cd13202
      Location:1312 → 1400
      FERM_C_MyoX; FERM domain C-lobe of Myosin X (MyoX, Myo10)
      cd13296
      Location:573 → 674
      PH2_MyoX; Myosin X Pleckstrin homology (PH) domain, repeat 2
      cd13297
      Location:739 → 864
      PH3_MyoX-like; Myosin X-like Pleckstrin homology (PH) domain, repeat 3
      cl22853
      Location:2 → 85
      Motor_domain; Myosin and Kinesin motor domain
      pfam00169
      Location:573 → 666
      PH; PH domain
      pfam00373
      Location:1154 → 1316
      FERM_M; FERM central domain
      pfam16735
      Location:241 → 291
      MYO10_CC; Unconventional myosin-X coiled coil domain
      cl00155
      Location:1063 → 1111
      UBQ; Ubiquitin-like proteins
      cl17171
      Location:539 → 581
      PH-like; Pleckstrin homology-like domain

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060929.1 Alternate T2T-CHM13v2.0

      Range
      16601148..16875413 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054352663.1 → XP_054208638.1  unconventional myosin-X isoform X1

      UniProtKB/TrEMBL
      A0A0A0MQX1
    2. XM_054352666.1 → XP_054208641.1  unconventional myosin-X isoform X3

      UniProtKB/TrEMBL
      B7Z3D4, B7ZA23
    3. XM_054352665.1 → XP_054208640.1  unconventional myosin-X isoform X3

      UniProtKB/TrEMBL
      B7Z3D4, B7ZA23
    4. XM_054352664.1 → XP_054208639.1  unconventional myosin-X isoform X2

      UniProtKB/TrEMBL
      B7ZA23
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