Mfap2 microfibrillar-associated protein 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Mfap2provided by MGI
Official Full Name: microfibrillar-associated protein 2provided by MGI
Primary source: MGI:MGI:99559
See related: Ensembl:ENSMUSG00000060572 AllianceGenome:MGI:99559
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Magp; Magp1; MAGP-1; MFAP-2
Summary: Enables fibrinogen binding activity and fibronectin binding activity. Involved in positive regulation of cold-induced thermogenesis. Acts upstream of or within platelet formation. Located in microfibril. Is expressed in several structures, including brain; embryo mesenchyme; eye; genitourinary system; and lung. Orthologous to human MFAP2 (microfibril associated protein 2). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in limb E14.5 (RPKM 107.3), ovary adult (RPKM 71.8) and 12 other tissues See more
Orthologs: human all
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Genomic context

Location:: 4 D3; 4 73.31 cM

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	4	NC_000070.7 (140737735..140743284)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	4	NC_000070.6 (141010424..141015976)

Chromosome 4 - NC_000070.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

MFAP2 promotes HSCs activation through FBN1/TGF-beta/Smad3 pathway.
Title: MFAP2 promotes HSCs activation through FBN1/TGF-β/Smad3 pathway.
MFAP2, upregulated by m1A methylation, promotes colorectal cancer invasiveness via CLK3.
Title: MFAP2, upregulated by m1A methylation, promotes colorectal cancer invasiveness via CLK3.
Microfibril-Associated Protein 2 (MFAP2) Potentiates Invasion and Migration of Melanoma by EMT and Wnt/beta-Catenin Pathway.
Title: Microfibril-Associated Protein 2 (MFAP2) Potentiates Invasion and Migration of Melanoma by EMT and Wnt/β-Catenin Pathway.
Data implicate systemic metabolic dysfunction in the development of bone fragility in germline Mfap2(-/-) mice. Also, MAGP1 protein was detected in the Mfap2(Prx-/-) hematopoietic bone marrow, despite of its absence in osseous bone matrix and its transcript at both sites. This suggests MAGP1 from a secondary site may accumulate in the bone marrow, but not into the bone matrix, during times of regional MAGP1 depletion.
Title: Contribution of metabolic disease to bone fragility in MAGP1-deficient mice.
Findings indicate that the regulation of TGF-beta by MAGP1 is protective against the effects of metabolic stress, and its absence predisposes individuals to metabolic dysfunction.
Title: The extracellular matrix protein MAGP1 supports thermogenesis and protects against obesity and diabetes through regulation of TGF-β.
These studies provide support for increased RANKL expression associated with MAGP1 deficiency and provide a link to altered TGF-beta signaling as a possible causative signaling pathway regulating RANKL expression in MAGP1-deficient osteoblasts.
Title: Oophorectomy-induced bone loss is attenuated in MAGP1-deficient mice.
MAGP1 is a regulator of bone remodeling, and its absence results in osteopenia associated with an increase in osteoclast number
Title: Microfibril-associated glycoprotein-1, an extracellular matrix regulator of bone remodeling.
microfibril-associated glycoprotein-1 has a role in complex phenotypes in multiple organ systems
Title: Deficiency in microfibril-associated glycoprotein-1 leads to complex phenotypes in multiple organ systems.
These findings show that MAGP1, a component of microfibrils and vascular elastic fibers, plays a role in hemostasis and thrombosis.
Title: Mice lacking the extracellular matrix protein MAGP1 display delayed thrombotic occlusion following vessel injury.
Site-directed and random mutagenesis demonstrated that a KLF sequence motif at -256/-270, an E-box at -222/-229, and a GC-box at -117/-125, are critical for the promoter function.
Title: Regulatory elements of microfibril-associated glycoprotein-1 gene expression in muscle cells.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3)
Targeted (3) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables extracellular matrix structural constituent	RCA inferred from Reviewed Computational Analysis more info	PubMed
enables fibrinogen binding	IDA Inferred from Direct Assay more info	PubMed
enables fibronectin binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in embryonic eye morphogenesis	IBA Inferred from Biological aspect of Ancestor more info
involved_in embryonic eye morphogenesis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within platelet formation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of cold-induced thermogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in post-embryonic eye morphogenesis	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in collagen-containing extracellular matrix	HDA more info	PubMed
located_in extracellular region	IEA Inferred from Electronic Annotation more info
is_active_in microfibril	IBA Inferred from Biological aspect of Ancestor more info
located_in microfibril	IDA Inferred from Direct Assay more info	PubMed
located_in microfibril	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: microfibrillar-associated protein 2

Names: microfibril-associated glycoprotein 1; microfibril-associated glycoprotein 1A; microfibril-associated glycoprotein 1D

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001161799.3 → NP_001155271.2 microfibrillar-associated protein 2 isoform a precursor

Status: VALIDATED

Source sequence(s)

AL645625

Consensus CDS

CCDS18860.2

UniProtKB/Swiss-Prot

P55002

UniProtKB/TrEMBL

Q99PM0

Related

ENSMUSP00000132711.4, ENSMUST00000166376.10

Conserved Domains (1) summary

pfam05507
Location:91 → 151

MAGP; Microfibril-associated glycoprotein (MAGP)
NM_001369292.2 → NP_001356221.1 microfibrillar-associated protein 2 isoform b

Status: VALIDATED

Source sequence(s)

AL645625

Conserved Domains (1) summary

pfam05507
Location:81 → 141

MAGP; Microfibril-associated glycoprotein (MAGP)
NM_001421243.2 → NP_001408172.2 microfibrillar-associated protein 2 isoform a precursor

Status: VALIDATED

Source sequence(s)

AL645625

UniProtKB/Swiss-Prot

P55002

UniProtKB/TrEMBL

Q99PM0
NM_008546.5 → NP_032572.3 microfibrillar-associated protein 2 isoform a precursor

Status: VALIDATED

Source sequence(s)

AL645625

Consensus CDS

CCDS18860.2

UniProtKB/Swiss-Prot

P55002

UniProtKB/TrEMBL

Q99PM0

Related

ENSMUSP00000071868.10, ENSMUST00000071977.10

Conserved Domains (1) summary

pfam05507
Location:91 → 151

MAGP; Microfibril-associated glycoprotein (MAGP)