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    PLAC8 placenta associated 8 [ Homo sapiens (human) ]

    Gene ID: 51316, updated on 27-Nov-2024

    Summary

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    Official Symbol
    PLAC8provided by HGNC
    Official Full Name
    placenta associated 8provided by HGNC
    Primary source
    HGNC:HGNC:19254
    See related
    Ensembl:ENSG00000145287 MIM:607515; AllianceGenome:HGNC:19254
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    C15; DGIC; onzin; PNAS-144
    Summary
    Predicted to enable chromatin binding activity. Predicted to be involved in positive regulation of cold-induced thermogenesis and positive regulation of transcription by RNA polymerase II. Predicted to act upstream of or within several processes, including brown fat cell differentiation; defense response to bacterium; and response to cold. Predicted to be located in azurophil granule lumen and extracellular region. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in bone marrow (RPKM 48.1), colon (RPKM 47.5) and 10 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See PLAC8 in Genome Data Viewer
    Location:
    4q21.22
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 4 NC_000004.12 (83090048..83114729, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 4 NC_060928.1 (86419237..86443896, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (84011201..84035882, complement)

    Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene lin-54 DREAM MuvB core complex component Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21668 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15537 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:83933797-83934682 Neighboring gene RNA, U6 small nuclear 615, pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21670 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21671 Neighboring gene Sharpr-MPRA regulatory region 7954 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21673 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21674 Neighboring gene H3K27ac hESC enhancer GRCh37_chr4:83956719-83957224 Neighboring gene COP9 signalosome subunit 4 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21676 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21677 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15539 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21678 Neighboring gene ReSE screen-validated silencer GRCh37_chr4:84042619-84042813 Neighboring gene uncharacterized LOC124900167 Neighboring gene Sharpr-MPRA regulatory region 10366 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr4:84091705-84092904 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21680 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:84102258-84102833 Neighboring gene ReSE screen-validated silencer GRCh37_chr4:84115858-84116088 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21681 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15540 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21682 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21683 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21684 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21685 Neighboring gene aminomethyltransferase pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Low m6A modification-mediated upregulation of PLAC8 promotes trophoblast cell invasion and migration in preeclampsia. Zhang Y, et al. Eur J Med Res, 2023 Oct 27. PMID 37885015, Free PMC Article
    2. Apoptosis suppression by candidate oncogene PLAC8 is reversed in other cell types. Mourtada-Maarabouni M, et al. Curr Cancer Drug Targets, 2013 Jan. PMID 22920440
    3. Epigenetic Regulation of Placenta-Specific 8 Contributes to Altered Function of Endothelial Colony-Forming Cells Exposed to Intrauterine Gestational Diabetes Mellitus. Blue EK, et al. Diabetes, 2015 Jul. PMID 25720387, Free PMC Article
    4. Expression of placenta-specific 8 in human oocytes, embryos, and models of in vitro implantation. Li M, et al. Fertil Steril, 2016 Sep 1. PMID 27322877
    5. Down-regulated PLAC8 promotes hepatocellular carcinoma cell proliferation by enhancing PI3K/Akt/GSK3β/Wnt/β-catenin signaling. Zou L, et al. Biomed Pharmacother, 2016 Dec. PMID 27643556

    See all (45) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Identification of PLAC8 as a Potential Biomarker for the Diagnosis of Interstitial Cystitis.
      Title: Identification of PLAC8 as a Potential Biomarker for the Diagnosis of Interstitial Cystitis.
    2. Low m6A modification-mediated upregulation of PLAC8 promotes trophoblast cell invasion and migration in preeclampsia.
      Title: Low m6A modification-mediated upregulation of PLAC8 promotes trophoblast cell invasion and migration in preeclampsia.
    3. PLAC8 contributes to the malignant behaviors of cervical cancer cells by activating the SOX4-mediated AKT pathway.
      Title: PLAC8 contributes to the malignant behaviors of cervical cancer cells by activating the SOX4-mediated AKT pathway.
    4. Modification of PLAC8 by UFM1 affects tumorous proliferation and immune response by impacting PD-L1 levels in triple-negative breast cancer.
      Title: Modification of PLAC8 by UFM1 affects tumorous proliferation and immune response by impacting PD-L1 levels in triple-negative breast cancer.
    5. Autophagy-linked plasma and lysosomal membrane protein PLAC8 is a key host factor for SARS-CoV-2 entry into human cells.
      Title: Autophagy-linked plasma and lysosomal membrane protein PLAC8 is a key host factor for SARS-CoV-2 entry into human cells.
    6. PLAC8 Overexpression Promotes Lung Cancer Cell Growth via Wnt/beta-Catenin Signaling.
      Title: PLAC8 Overexpression Promotes Lung Cancer Cell Growth via Wnt/β-Catenin Signaling.
    7. Placenta-specific 8 (PLAC8) mediates inflammation and mobility of the hPDLCs via MEK/ERK signaling pathway.
      Title: Placenta-specific 8 (PLAC8) mediates inflammation and mobility of the hPDLCs via MEK/ERK signaling pathway.
    8. Long noncoding RNA HOXD-AS1 promotes the progression of pancreatic cancer through miR-664b-3p/PLAC8 axis.
      Title: Long noncoding RNA HOXD-AS1 promotes the progression of pancreatic cancer through miR-664b-3p/PLAC8 axis.
    9. PLAC8 promotes adriamycin resistance via blocking autophagy in breast cancer.
      Title: PLAC8 promotes adriamycin resistance via blocking autophagy in breast cancer.
    10. PLAC8 promotes the autophagic activity and improves the growth priority of human trophoblast cells.
      Title: PLAC8 promotes the autophagic activity and improves the growth priority of human trophoblast cells.
    Submit: New GeneRIF Correction See all GeneRIFs (32)

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables chromatin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in brown fat cell differentiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in defense response to bacterium IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of apoptotic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of multicellular organism growth IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of cell population proliferation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of cold-induced thermogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in response to cold IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in azurophil granule lumen TAS
    Traceable Author Statement
    more info
    		  
    located_in extracellular region TAS
    Traceable Author Statement
    more info
    		  

    General protein information

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    Preferred Names
    placenta-specific gene 8 protein
    Names
    down-regulated in gastrointestinal cancer protein
    placenta specific 8

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001130715.2 → NP_001124187.1  placenta-specific gene 8 protein

      See identical proteins and their annotated locations for NP_001124187.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) uses an alternate splice site in the 3' UTR, compared to variant 1.
      Source sequence(s)
      AC073840, AK000140
      Consensus CDS
      CCDS3601.1
      UniProtKB/Swiss-Prot
      C1K3N2, Q9NZF1
      UniProtKB/TrEMBL
      A0A024RDH7, Q96EJ4, X2BQ60
      Related
      ENSP00000399700.2, ENST00000426923.3
      Conserved Domains (1) summary
      cl04722
      Location:24 → 108
      PLAC8; PLAC8 family

    2. NM_001130716.2 → NP_001124188.1  placenta-specific gene 8 protein

      See identical proteins and their annotated locations for NP_001124188.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript.
      Source sequence(s)
      AC073840, BI824905
      Consensus CDS
      CCDS3601.1
      UniProtKB/Swiss-Prot
      C1K3N2, Q9NZF1
      UniProtKB/TrEMBL
      A0A024RDH7, Q96EJ4, X2BQ60
      Related
      ENSP00000412230.2, ENST00000411416.7
      Conserved Domains (1) summary
      cl04722
      Location:24 → 108
      PLAC8; PLAC8 family

    3. NM_016619.3 → NP_057703.1  placenta-specific gene 8 protein

      See identical proteins and their annotated locations for NP_057703.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1.
      Source sequence(s)
      AC073840, AK000140
      Consensus CDS
      CCDS3601.1
      UniProtKB/Swiss-Prot
      C1K3N2, Q9NZF1
      UniProtKB/TrEMBL
      A0A024RDH7, Q96EJ4, X2BQ60
      Related
      ENSP00000309509.4, ENST00000311507.9
      Conserved Domains (1) summary
      cl04722
      Location:24 → 108
      PLAC8; PLAC8 family

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000004.12 Reference GRCh38.p14 Primary Assembly

      Range
      83090048..83114729 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060928.1 Alternate T2T-CHM13v2.0

      Range
      86419237..86443896 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9NZF1.1 GenPept UniProtKB/Swiss-Prot:Q9NZF1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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