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    SSP120 Ssp120p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 850952, updated on 9-Dec-2024

    Summary

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    Official Symbol
    SSP120
    Official Full Name
    Ssp120p
    Primary source
    SGD:S000004240
    Locus tag
    YLR250W
    See related
    AllianceGenome:SGD:S000004240; FungiDB:YLR250W; VEuPathDB:YLR250W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Predicted to enable calcium ion binding activity. Located in fungal-type vacuole. Orthologous to human NUCB1 (nucleobindin 1) and NUCB2 (nucleobindin 2). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See SSP120 in Genome Data Viewer
    Location:
    chromosome: XII
    Exon count:
    1
    Sequence:
    Chromosome: XII; NC_001144.5 (640317..641021)

    Chromosome XII - NC_001144.5Genomic Context describing neighboring genes Neighboring gene serine/threonine protein kinase RCK2 Neighboring gene translation elongation factor EF-3 Neighboring gene ethanol metabolism protein Neighboring gene Cqd2p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001144.5

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Selection of secretory protein-encoding genes by fusion with PHO5 in Saccharomyces cerevisiae. Sidhu RS, et al. Gene, 1991 Oct 30. PMID 1743509
    2. Analysis of COPII Vesicles Indicates a Role for the Emp47-Ssp120 Complex in Transport of Cell Surface Glycoproteins. Margulis NG, et al. Traffic, 2016 Mar. PMID 26650540, Free PMC Article
    3. Systematic analysis of membrane contact sites in Saccharomyces cerevisiae uncovers modulators of cellular lipid distribution. Castro IG, et al. Elife, 2022 Nov 10. PMID 36354737, Free PMC Article
    4. Genome-wide survey of yeast mutations leading to activation of the yeast cell integrity MAPK pathway: novel insights into diverse MAPK outcomes. Arias P, et al. BMC Genomics, 2011 Aug 2. PMID 21810245, Free PMC Article
    5. Pex19 is involved in importing dually targeted tail-anchored proteins to both mitochondria and peroxisomes. Cichocki BA, et al. Traffic, 2018 Oct. PMID 30033679

    See all (34) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables calcium ion binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm HDA PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in endoplasmic reticulum-Golgi intermediate compartment IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in fungal-type vacuole HDA PubMed 
    located_in intracellular membrane-bounded organelle IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Ssp120p
    NP_013351.1
    • Protein packaged into COPII vesicles for ER to Golgi trafficking; forms a complex with Emp47p that may function in trafficking plasma membrane glycoproteins through early secretory pathway; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001144.5 Reference assembly

      Range
      640317..641021
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001182137.1 → NP_013351.1  TPA: Ssp120p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_013351.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VYP8, P39931
      UniProtKB/TrEMBL
      A7A1D3, B3RHD5, C7GQY6, C8ZDL3, G2WJ76, N1P6Y2
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P39931.1

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