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    KNS1 serine/threonine protein kinase KNS1 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 850641, updated on 9-Dec-2024

    Summary

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    Official Symbol
    KNS1
    Official Full Name
    serine/threonine protein kinase KNS1
    Primary source
    SGD:S000003942
    Locus tag
    YLL019C
    See related
    AllianceGenome:SGD:S000003942; FungiDB:YLL019C; VEuPathDB:YLL019C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables protein serine/threonine kinase activity and protein tyrosine kinase activity. Involved in negative regulation of transcription by RNA polymerase III. Located in cytoplasm and nucleus. Orthologous to several human genes including CLK1 (CDC like kinase 1); CLK2 (CDC like kinase 2); and CLK3 (CDC like kinase 3). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See KNS1 in Genome Data Viewer
    Location:
    chromosome: XII
    Exon count:
    1
    Sequence:
    Chromosome: XII; NC_001144.5 (105686..107899, complement)

    Chromosome XII - NC_001144.5Genomic Context describing neighboring genes Neighboring gene Hif1p Neighboring gene Spa2p Neighboring gene Cox19p Neighboring gene aspartate--tRNA ligase DPS1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001144.5

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Negative regulation of filamentous growth and flocculation by Lkh1, a fission yeast LAMMER kinase homolog. Kim KH, et al. Biochem Biophys Res Commun, 2001 Dec 21. PMID 11741326
    2. The KNS1 gene of Saccharomyces cerevisiae encodes a nonessential protein kinase homologue that is distantly related to members of the CDC28/cdc2 gene family. Padmanabha R, et al. Mol Gen Genet, 1991 Sep. PMID 1910150
    3. TOR signaling regulates ribosome and tRNA synthesis via LAMMER/Clk and GSK-3 family kinases. Lee J, et al. Mol Cell, 2012 Mar 30. PMID 22364741, Free PMC Article
    4. Activity and autophosphorylation of LAMMER protein kinases. Lee K, et al. J Biol Chem, 1996 Nov 1. PMID 8910305
    5. TORC1 signaling regulates cytoplasmic pH through Sir2 in yeast. Devare MN, et al. Aging Cell, 2020 Jun. PMID 32449834, Free PMC Article

    See all (39) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Ckb1 is differentially phosphorylated in vivo and that Kns1 mediates this phosphorylation when nutrients are limiting and under all tested stress conditions.
      Title: Differential phosphorylation of a regulatory subunit of protein kinase CK2 by target of rapamycin complex 1 signaling and the Cdc-like kinase Kns1.
    2. Kns1 and Mck1 are conserved protein kinases that function downstream of TORC1. Efficient repression of ribosome and tRNA synthesis requires Kns1 and Mck1
      Title: TOR signaling regulates ribosome and tRNA synthesis via LAMMER/Clk and GSK-3 family kinases.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2AXY142 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3Y41 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein kinase activity HDA PubMed 
    enables protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein serine/threonine kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables protein serine/threonine/tyrosine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein tyrosine kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein tyrosine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein tyrosine kinase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in chromatin remodeling IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of transcription by RNA polymerase III IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of transcription by RNA polymerase III IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in negative regulation of transcription by RNA polymerase III IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of RNA splicing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    serine/threonine protein kinase KNS1
    NP_013081.1
    • Protein kinase involved in negative regulation of PolIII transcription; effector kinase of the TOR signaling pathway and phosphorylates Rpc53p to regulate ribosome and tRNA biosynthesis; member of the LAMMER family of protein kinases, which are serine/threonine kinases also capable of phosphorylating tyrosine residues; capable of autophosphorylation

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001144.5 Reference assembly

      Range
      105686..107899 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001181839.1 → NP_013081.1  TPA: serine/threonine protein kinase KNS1 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_013081.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VXY4, P32350, Q12399
      UniProtKB/TrEMBL
      A7A0N7, B3LTF0, B5VMS7, C8ZCV3
      Conserved Domains (1) summary
      cd14134
      Location:298 → 720
      PKc_CLK; Catalytic domain of the Dual-specificity protein kinases, CDC-like kinases
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P32350.2

    Gene LinkOut

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