U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    HECTD1 HECT domain E3 ubiquitin protein ligase 1 [ Homo sapiens (human) ]

    Gene ID: 25831, updated on 27-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    HECTD1provided by HGNC
    Official Full Name
    HECT domain E3 ubiquitin protein ligase 1provided by HGNC
    Primary source
    HGNC:HGNC:20157
    See related
    Ensembl:ENSG00000092148 MIM:618649; AllianceGenome:HGNC:20157
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    EULIR
    Summary
    Enables ubiquitin protein ligase activity. Predicted to be involved in positive regulation of proteasomal ubiquitin-dependent protein catabolic process; proteasome-mediated ubiquitin-dependent protein catabolic process; and protein polyubiquitination. Predicted to act upstream of or within several processes, including chordate embryonic development; circulatory system development; and protein ubiquitination. Predicted to be active in nuclear speck. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in thyroid (RPKM 22.9), testis (RPKM 20.1) and 25 other tissues See more
    Orthologs
    mouse all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See HECTD1 in Genome Data Viewer
    Location:
    14q12
    Exon count:
    45
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 14 NC_000014.9 (31100117..31207793, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 14 NC_060938.1 (25297934..25405840, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (31569323..31676999, complement)

    Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene striatin 3 Neighboring gene intraflagellar transport 20 homolog (Chlamydomonas) pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8227 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8228 Neighboring gene ReSE screen-validated silencer GRCh37_chr14:31494803-31494984 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5650 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5651 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8229 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:31516497-31517022 Neighboring gene adaptor related protein complex 4 subunit sigma 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5652 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:31591905-31592742 Neighboring gene ribosomal protein L21 pseudogene 5 Neighboring gene RNA, U6 small nuclear 541, pseudogene Neighboring gene Sharpr-MPRA regulatory region 7641 Neighboring gene H3K27ac hESC enhancer GRCh37_chr14:31675891-31676404 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5654 Neighboring gene H3K27ac hESC enhancer GRCh37_chr14:31676917-31677428 Neighboring gene H3K27ac hESC enhancer GRCh37_chr14:31677429-31677940 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:31721909-31722408 Neighboring gene Sharpr-MPRA regulatory region 13013 Neighboring gene Sharpr-MPRA regulatory region 11779 Neighboring gene uncharacterized LOC124903438 Neighboring gene asparaginyl-tRNA synthetase 1 pseudogene 1 Neighboring gene HEAT repeat containing 5A

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Expression

    Go to the top of the page Help
    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. HECTD1 promotes base excision repair in nucleosomes through chromatin remodelling. Bennett L, et al. Nucleic Acids Res, 2020 Feb 20. PMID 31799632, Free PMC Article
    2. Identification and functional analysis of rare HECTD1 missense variants in human neural tube defects. Oxman E, et al. Hum Genet, 2024 Mar. PMID 38451291, Free PMC Article
    3. Nucleoporin 93, a new substrate of the E3 ubiquitin protein ligase HECTD1, promotes esophageal squamous cell carcinoma progression. Zhang J, et al. Hum Cell, 2024 Jan. PMID 37993750
    4. Basic Tilted Helix Bundle - a new protein fold in human FKBP25/FKBP3 and HectD1. Helander S, et al. Biochem Biophys Res Commun, 2014 Apr 25. PMID 24667607, Free PMC Article
    5. HECTD1 regulates the expression of SNAIL: Implications for epithelial‑mesenchymal transition. Wang X, et al. Int J Oncol, 2020 May. PMID 32319576, Free PMC Article

    See all (103) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Identification and functional analysis of rare HECTD1 missense variants in human neural tube defects.
      Title: Identification and functional analysis of rare HECTD1 missense variants in human neural tube defects.
    2. Nucleoporin 93, a new substrate of the E3 ubiquitin protein ligase HECTD1, promotes esophageal squamous cell carcinoma progression.
      Title: Nucleoporin 93, a new substrate of the E3 ubiquitin protein ligase HECTD1, promotes esophageal squamous cell carcinoma progression.
    3. The E3 ubiquitin ligase HECTD1 contributes to cell proliferation through an effect on mitosis.
      Title: The E3 ubiquitin ligase HECTD1 contributes to cell proliferation through an effect on mitosis.
    4. Circular RNA circHECTD1 facilitates glioma progression by regulating the miR-296-3p/SLC10A7 axis.
      Title: Circular RNA circHECTD1 facilitates glioma progression by regulating the miR-296-3p/SLC10A7 axis.
    5. The deubiquitinase TRABID stabilizes the K29/K48-specific E3 ubiquitin ligase HECTD1.
      Title: The deubiquitinase TRABID stabilizes the K29/K48-specific E3 ubiquitin ligase HECTD1.
    6. CircHECTD1 up-regulates mucin 1 expression to accelerate hepatocellular carcinoma development by targeting microRNA-485-5p via a competing endogenous RNA mechanism.
      Title: CircHECTD1 up-regulates mucin 1 expression to accelerate hepatocellular carcinoma development by targeting microRNA-485-5p via a competing endogenous RNA mechanism.
    7. HECTD1 regulates the expression of SNAIL: Implications for epithelialmesenchymal transition.
      Title: HECTD1 regulates the expression of SNAIL: Implications for epithelial‑mesenchymal transition.
    8. we have now identified HECTD1 as an important factor in promoting Base excision repair (BER) in chromatin.
      Title: HECTD1 promotes base excision repair in nucleosomes through chromatin remodelling.
    9. SiO2 concomitantly increased circHECTD1 expression, which, in turn, inhibited HECTD1 protein expression.
      Title: circHECTD1 promotes the silica-induced pulmonary endothelial-mesenchymal transition via HECTD1.
    10. HECTD1 may be involved in the regulation of ABCA1-mediated cholesterol export from unloaded macrophages to apoA-I.
      Title: The E3 ubiquitin ligase, HECTD1, is involved in ABCA1-mediated cholesterol export from macrophages.
    Submit: New GeneRIF Correction See all GeneRIFs (13)

    Phenotypes

    Go to the top of the page Help

    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

    Go to the top of the page Help

    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Clone Names

    • FLJ38315, KIAA1131

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables ubiquitin protein ligase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables ubiquitin protein ligase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within aorta development ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    acts_upstream_of_or_within heart valve development ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in positive regulation of proteasomal ubiquitin-dependent protein catabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    acts_upstream_of_or_within ventricular septum development ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    E3 ubiquitin-protein ligase HECTD1
    Names
    E3 ligase for inhibin receptor
    HECT domain containing E3 ubiquitin protein ligase 1
    HECT domain-containing protein 1
    HECT-type E3 ubiquitin transferase HECTD1
    NP_001397939.1
    NP_056197.3
    XP_005267559.2
    XP_011534921.1
    XP_011534923.1
    XP_011534924.1
    XP_016876637.1
    XP_016876638.1
    XP_016876640.1
    XP_016876641.1
    XP_016876642.1
    XP_024305294.1
    XP_024305295.1
    XP_047287157.1
    XP_047287158.1
    XP_047287159.1
    XP_047287160.1
    XP_047287161.1
    XP_047287162.1
    XP_047287163.1
    XP_047287164.1
    XP_054231745.1
    XP_054231746.1
    XP_054231747.1
    XP_054231748.1
    XP_054231749.1
    XP_054231750.1
    XP_054231751.1
    XP_054231752.1
    XP_054231753.1
    XP_054231754.1
    XP_054231755.1
    XP_054231756.1
    XP_054231757.1
    XP_054231758.1
    XP_054231759.1
    XP_054231760.1
    XP_054231761.1
    XP_054231762.1
    XP_054231763.1

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001411010.1 → NP_001397939.1  E3 ubiquitin-protein ligase HECTD1 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AL121808, AL136418, KC877516
      Consensus CDS
      CCDS91860.1
      UniProtKB/TrEMBL
      A0A8I5QJU2, H0YJP0
      Related
      ENSP00000510470.1, ENST00000692835.1

    2. NM_015382.4 → NP_056197.3  E3 ubiquitin-protein ligase HECTD1 isoform 1

      See identical proteins and their annotated locations for NP_056197.3

      Status: VALIDATED

      Source sequence(s)
      AB032957, AL136418, AY254380, BM977042, DA440215, DA509926, DA818448
      Consensus CDS
      CCDS41939.1
      UniProtKB/Swiss-Prot
      D3DS86, Q6P445, Q86VJ1, Q96F34, Q9UFZ7, Q9ULT8
      UniProtKB/TrEMBL
      H0YJP0
      Related
      ENSP00000382269.1, ENST00000399332.6
      Conserved Domains (6) summary
      cd00078
      Location:2131 → 2608
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      sd00045
      Location:396 → 426
      ANK; ANK repeat [structural motif]
      pfam06701
      Location:1277 → 1335
      MIB_HERC2; Mib_herc2
      pfam07738
      Location:1107 → 1240
      Sad1_UNC; Sad1 / UNC-like C-terminal
      pfam12796
      Location:366 → 457
      Ank_2; Ankyrin repeats (3 copies)
      pfam18410
      Location:1892 → 1965
      BTHB; Basic tilted helix bundle domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000014.9 Reference GRCh38.p14 Primary Assembly

      Range
      31100117..31207793 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017021153.2 → XP_016876642.1  E3 ubiquitin-protein ligase HECTD1 isoform X10

      UniProtKB/TrEMBL
      A0A8I5KU01, H0YJD4
      Related
      ENSP00000451260.2, ENST00000554882.6

    2. XM_047431208.1 → XP_047287164.1  E3 ubiquitin-protein ligase HECTD1 isoform X11

      UniProtKB/TrEMBL
      A0A8I5KU01

    3. XM_011536621.3 → XP_011534923.1  E3 ubiquitin-protein ligase HECTD1 isoform X9

      See identical proteins and their annotated locations for XP_011534923.1

      UniProtKB/TrEMBL
      A0A8I5KU01
      Conserved Domains (6) summary
      cd00078
      Location:1852 → 2329
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      sd00045
      Location:396 → 426
      ANK; ANK repeat [structural motif]
      pfam06701
      Location:1277 → 1302
      MIB_HERC2; Mib_herc2
      pfam07738
      Location:1107 → 1240
      Sad1_UNC; Sad1 / UNC-like C-terminal
      pfam12796
      Location:366 → 457
      Ank_2; Ankyrin repeats (3 copies)
      pfam18410
      Location:1613 → 1686
      BTHB; Basic tilted helix bundle domain

    4. XM_047431201.1 → XP_047287157.1  E3 ubiquitin-protein ligase HECTD1 isoform X4

      UniProtKB/TrEMBL
      H0YJP0

    5. XM_047431206.1 → XP_047287162.1  E3 ubiquitin-protein ligase HECTD1 isoform X7

      UniProtKB/TrEMBL
      H0YJP0

    6. XM_047431204.1 → XP_047287160.1  E3 ubiquitin-protein ligase HECTD1 isoform X6

      UniProtKB/TrEMBL
      H0YJP0

    7. XM_011536619.3 → XP_011534921.1  E3 ubiquitin-protein ligase HECTD1 isoform X2

      See identical proteins and their annotated locations for XP_011534921.1

      UniProtKB/TrEMBL
      A0A087X2H1, H0YJP0
      Conserved Domains (6) summary
      cd00078
      Location:2129 → 2606
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      sd00045
      Location:396 → 426
      ANK; ANK repeat [structural motif]
      pfam06701
      Location:1277 → 1335
      MIB_HERC2; Mib_herc2
      pfam07738
      Location:1107 → 1240
      Sad1_UNC; Sad1 / UNC-like C-terminal
      pfam12796
      Location:366 → 457
      Ank_2; Ankyrin repeats (3 copies)
      pfam18410
      Location:1890 → 1963
      BTHB; Basic tilted helix bundle domain

    8. XM_047431202.1 → XP_047287158.1  E3 ubiquitin-protein ligase HECTD1 isoform X5

      UniProtKB/TrEMBL
      H0YJP0

    9. XM_005267502.4 → XP_005267559.2  E3 ubiquitin-protein ligase HECTD1 isoform X1

      See identical proteins and their annotated locations for XP_005267559.2

      UniProtKB/Swiss-Prot
      D3DS86, Q6P445, Q86VJ1, Q96F34, Q9UFZ7, Q9ULT8
      UniProtKB/TrEMBL
      H0YJP0
      Related
      ENSP00000450697.1, ENST00000553700.5
      Conserved Domains (6) summary
      cd00078
      Location:2131 → 2608
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      sd00045
      Location:396 → 426
      ANK; ANK repeat [structural motif]
      pfam06701
      Location:1277 → 1335
      MIB_HERC2; Mib_herc2
      pfam07738
      Location:1107 → 1240
      Sad1_UNC; Sad1 / UNC-like C-terminal
      pfam12796
      Location:366 → 457
      Ank_2; Ankyrin repeats (3 copies)
      pfam18410
      Location:1892 → 1965
      BTHB; Basic tilted helix bundle domain

    10. XM_017021152.3 → XP_016876641.1  E3 ubiquitin-protein ligase HECTD1 isoform X10

      UniProtKB/TrEMBL
      A0A8I5KU01, H0YJD4

    11. XM_017021151.3 → XP_016876640.1  E3 ubiquitin-protein ligase HECTD1 isoform X9

      UniProtKB/TrEMBL
      A0A8I5KU01
      Related
      ENSP00000508604.1, ENST00000691390.1
      Conserved Domains (6) summary
      cd00078
      Location:1852 → 2329
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      sd00045
      Location:396 → 426
      ANK; ANK repeat [structural motif]
      pfam06701
      Location:1277 → 1302
      MIB_HERC2; Mib_herc2
      pfam07738
      Location:1107 → 1240
      Sad1_UNC; Sad1 / UNC-like C-terminal
      pfam12796
      Location:366 → 457
      Ank_2; Ankyrin repeats (3 copies)
      pfam18410
      Location:1613 → 1686
      BTHB; Basic tilted helix bundle domain

    12. XM_047431207.1 → XP_047287163.1  E3 ubiquitin-protein ligase HECTD1 isoform X8

      UniProtKB/TrEMBL
      H0YJP0

    13. XM_017021149.3 → XP_016876638.1  E3 ubiquitin-protein ligase HECTD1 isoform X4

      UniProtKB/TrEMBL
      H0YJP0
      Conserved Domains (6) summary
      cd00078
      Location:2082 → 2559
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      sd00045
      Location:396 → 426
      ANK; ANK repeat [structural motif]
      pfam06701
      Location:1277 → 1321
      MIB_HERC2; Mib_herc2
      pfam07738
      Location:1107 → 1240
      Sad1_UNC; Sad1 / UNC-like C-terminal
      pfam12796
      Location:366 → 457
      Ank_2; Ankyrin repeats (3 copies)
      pfam18410
      Location:1843 → 1916
      BTHB; Basic tilted helix bundle domain

    14. XM_047431205.1 → XP_047287161.1  E3 ubiquitin-protein ligase HECTD1 isoform X7

      UniProtKB/TrEMBL
      H0YJP0

    15. XM_017021148.3 → XP_016876637.1  E3 ubiquitin-protein ligase HECTD1 isoform X3

      UniProtKB/TrEMBL
      A0A8I5QJU2, H0YJP0
      Conserved Domains (6) summary
      cd00078
      Location:2084 → 2561
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      sd00045
      Location:396 → 426
      ANK; ANK repeat [structural motif]
      pfam06701
      Location:1277 → 1321
      MIB_HERC2; Mib_herc2
      pfam07738
      Location:1107 → 1240
      Sad1_UNC; Sad1 / UNC-like C-terminal
      pfam12796
      Location:366 → 457
      Ank_2; Ankyrin repeats (3 copies)
      pfam18410
      Location:1845 → 1918
      BTHB; Basic tilted helix bundle domain

    16. XM_047431203.1 → XP_047287159.1  E3 ubiquitin-protein ligase HECTD1 isoform X6

      UniProtKB/TrEMBL
      H0YJP0

    17. XM_024449526.2 → XP_024305294.1  E3 ubiquitin-protein ligase HECTD1 isoform X2

      UniProtKB/TrEMBL
      A0A087X2H1, H0YJP0
      Related
      ENSP00000484981.2, ENST00000611816.5
      Conserved Domains (6) summary
      cd00078
      Location:2129 → 2606
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      sd00045
      Location:396 → 426
      ANK; ANK repeat [structural motif]
      pfam06701
      Location:1277 → 1335
      MIB_HERC2; Mib_herc2
      pfam07738
      Location:1107 → 1240
      Sad1_UNC; Sad1 / UNC-like C-terminal
      pfam12796
      Location:366 → 457
      Ank_2; Ankyrin repeats (3 copies)
      pfam18410
      Location:1890 → 1963
      BTHB; Basic tilted helix bundle domain

    18. XM_024449527.2 → XP_024305295.1  E3 ubiquitin-protein ligase HECTD1 isoform X5

      UniProtKB/TrEMBL
      H0YJP0
      Conserved Domains (5) summary
      cd00078
      Location:2070 → 2547
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      sd00045
      Location:396 → 426
      ANK; ANK repeat [structural motif]
      pfam06701
      Location:1277 → 1335
      MIB_HERC2; Mib_herc2
      pfam07738
      Location:1107 → 1240
      Sad1_UNC; Sad1 / UNC-like C-terminal
      pfam12796
      Location:366 → 457
      Ank_2; Ankyrin repeats (3 copies)

    19. XM_011536622.2 → XP_011534924.1  E3 ubiquitin-protein ligase HECTD1 isoform X12

      Conserved Domains (4) summary
      smart00119
      Location:1605 → 2057
      HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
      cd00078
      Location:1581 → 2058
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      pfam06701
      Location:727 → 785
      MIB_HERC2; Mib_herc2
      cl23730
      Location:557 → 690
      F5_F8_type_C; F5/8 type C domain

    RNA

    1. XR_001750215.3 RNA Sequence

      Related
      ENST00000687002.1

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060938.1 Alternate T2T-CHM13v2.0

      Range
      25297934..25405840 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054375770.1 → XP_054231745.1  E3 ubiquitin-protein ligase HECTD1 isoform X1

      UniProtKB/Swiss-Prot
      D3DS86, Q6P445, Q86VJ1, Q96F34, Q9UFZ7, Q9ULT8
      UniProtKB/TrEMBL
      H0YJP0

    2. XM_054375776.1 → XP_054231751.1  E3 ubiquitin-protein ligase HECTD1 isoform X5

      UniProtKB/TrEMBL
      H0YJP0

    3. XM_054375772.1 → XP_054231747.1  E3 ubiquitin-protein ligase HECTD1 isoform X2

      UniProtKB/TrEMBL
      A0A087X2H1, H0YJP0

    4. XM_054375786.1 → XP_054231761.1  E3 ubiquitin-protein ligase HECTD1 isoform X10

      UniProtKB/TrEMBL
      A0A8I5KU01, H0YJD4

    5. XM_054375787.1 → XP_054231762.1  E3 ubiquitin-protein ligase HECTD1 isoform X11

      UniProtKB/TrEMBL
      A0A8I5KU01

    6. XM_054375783.1 → XP_054231758.1  E3 ubiquitin-protein ligase HECTD1 isoform X9

      UniProtKB/TrEMBL
      A0A8I5KU01

    7. XM_054375775.1 → XP_054231750.1  E3 ubiquitin-protein ligase HECTD1 isoform X4

      UniProtKB/TrEMBL
      H0YJP0

    8. XM_054375781.1 → XP_054231756.1  E3 ubiquitin-protein ligase HECTD1 isoform X7

      UniProtKB/TrEMBL
      H0YJP0

    9. XM_054375779.1 → XP_054231754.1  E3 ubiquitin-protein ligase HECTD1 isoform X6

      UniProtKB/TrEMBL
      H0YJP0

    10. XM_054375785.1 → XP_054231760.1  E3 ubiquitin-protein ligase HECTD1 isoform X10

      UniProtKB/TrEMBL
      A0A8I5KU01, H0YJD4

    11. XM_054375784.1 → XP_054231759.1  E3 ubiquitin-protein ligase HECTD1 isoform X9

      UniProtKB/TrEMBL
      A0A8I5KU01

    12. XM_054375782.1 → XP_054231757.1  E3 ubiquitin-protein ligase HECTD1 isoform X8

      UniProtKB/TrEMBL
      H0YJP0

    13. XM_054375774.1 → XP_054231749.1  E3 ubiquitin-protein ligase HECTD1 isoform X4

      UniProtKB/TrEMBL
      H0YJP0

    14. XM_054375780.1 → XP_054231755.1  E3 ubiquitin-protein ligase HECTD1 isoform X7

      UniProtKB/TrEMBL
      H0YJP0

    15. XM_054375773.1 → XP_054231748.1  E3 ubiquitin-protein ligase HECTD1 isoform X3

      UniProtKB/TrEMBL
      A0A8I5QJU2, H0YJP0

    16. XM_054375778.1 → XP_054231753.1  E3 ubiquitin-protein ligase HECTD1 isoform X6

      UniProtKB/TrEMBL
      H0YJP0

    17. XM_054375771.1 → XP_054231746.1  E3 ubiquitin-protein ligase HECTD1 isoform X2

      UniProtKB/TrEMBL
      A0A087X2H1, H0YJP0

    18. XM_054375777.1 → XP_054231752.1  E3 ubiquitin-protein ligase HECTD1 isoform X5

      UniProtKB/TrEMBL
      H0YJP0

    19. XM_054375788.1 → XP_054231763.1  E3 ubiquitin-protein ligase HECTD1 isoform X12

    RNA

    1. XR_008488851.1 RNA Sequence

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9ULT8.4 GenPept UniProtKB/Swiss-Prot:Q9ULT8

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous