GFA1 glutamine--fructose-6-phosphate transaminase (isomerizing) GFA1 [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: GFA1
Official Full Name: glutamine--fructose-6-phosphate transaminase (isomerizing) GFA1
Primary source: SGD:S000001587
Locus tag: YKL104C
See related: AllianceGenome:SGD:S000001587; FungiDB:YKL104C; VEuPathDB:YKL104C
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Enables glutamine-fructose-6-phosphate transaminase (isomerizing) activity. Involved in chitin biosynthetic process. Human ortholog(s) of this gene implicated in congenital myasthenic syndrome 12; obesity; and type 2 diabetes mellitus. Orthologous to several human genes including GFPT1 (glutamine--fructose-6-phosphate transaminase 1). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See GFA1 in Genome Data Viewer

Location:: chromosome: XI

Exon count:: 1

Sequence:: Chromosome: XI; NC_001143.9 (243220..245373, complement)

Chromosome XI - NC_001143.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001143.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables carbohydrate derivative binding	IEA Inferred from Electronic Annotation more info
enables glutamine-fructose-6-phosphate transaminase (isomerizing) activity	IBA Inferred from Biological aspect of Ancestor more info
enables glutamine-fructose-6-phosphate transaminase (isomerizing) activity	IDA Inferred from Direct Assay more info	PubMed
enables glutamine-fructose-6-phosphate transaminase (isomerizing) activity	IEA Inferred from Electronic Annotation more info
enables transaminase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in UDP-N-acetylglucosamine biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in UDP-N-acetylglucosamine metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in carbohydrate derivative metabolic process	IEA Inferred from Electronic Annotation more info
involved_in chitin biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in chitin biosynthetic process	IGI Inferred from Genetic Interaction more info	PubMed
involved_in fructose 6-phosphate metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein N-linked glycosylation	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cellular_component	ND No biological Data available more info

General protein information

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Preferred Names: glutamine--fructose-6-phosphate transaminase (isomerizing) GFA1

NP_012818.1

EC 2.6.1.16

Glutamine-fructose-6-phosphate amidotransferase; catalyzes the formation of glucosamine-6-P and glutamate from fructose-6-P and glutamine in the first step of chitin biosynthesis; GFA1 has a paralogous region, comprising ORFs YMR084W-YMR085W, that arose from the whole genome duplication

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001143.9 Reference assembly

Range

243220..245373 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001179670.1 → NP_012818.1 TPA: glutamine--fructose-6-phosphate transaminase (isomerizing) GFA1 [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_012818.1

Status: REVIEWED

UniProtKB/Swiss-Prot

D6VXI4, P14742

UniProtKB/TrEMBL

A6ZZL3, B3LQZ2, B5VM55, C7GVK7, C8ZC71, G2WHT0, N1P050, V5RD14

Conserved Domains (1) summary

PLN02981
Location:1 → 717

PLN02981; glucosamine:fructose-6-phosphate aminotransferase