RPL17A ribosomal 60S subunit protein L17A [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: RPL17A
Official Full Name: ribosomal 60S subunit protein L17A
Primary source: SGD:S000001663
Locus tag: YKL180W
See related: AllianceGenome:SGD:S000001663; FungiDB:YKL180W; VEuPathDB:YKL180W
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as: RPL17
Summary: A structural constituent of ribosome. Involved in cleavage in ITS2 between 5.8S rRNA and LSU-rRNA of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) and cytoplasmic translation. Located in cytoplasm. Part of cytosolic large ribosomal subunit and preribosome, large subunit precursor. Orthologous to human RPL17 (ribosomal protein L17). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See RPL17A in Genome Data Viewer

Location:: chromosome: XI

Exon count:: 2

Sequence:: Chromosome: XI; NC_001143.9 (109269..110129)

Chromosome XI - NC_001143.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001143.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

our findings indicate that the dedicated chaperone Acl4 accompanies Rpl4 from the cytoplasm to its pre-60S assembly site in the nucleus.
Title: The Dedicated Chaperone Acl4 Escorts Ribosomal Protein Rpl4 to Its Nuclear Pre-60S Assembly Site.
Interaction of nascent chains with the ribosomal tunnel proteins Rpl4, Rpl17, and Rpl39
Title: Interaction of nascent chains with the ribosomal tunnel proteins Rpl4, Rpl17, and Rpl39 of Saccharomyces cerevisiae.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables structural constituent of ribosome	IBA Inferred from Biological aspect of Ancestor more info
enables structural constituent of ribosome	IDA Inferred from Direct Assay more info	PubMed
enables structural constituent of ribosome	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in cleavage in ITS2 between 5.8S rRNA and LSU-rRNA of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	IGI Inferred from Genetic Interaction more info	PubMed
involved_in cytoplasmic translation	IBA Inferred from Biological aspect of Ancestor more info
involved_in cytoplasmic translation	IDA Inferred from Direct Assay more info	PubMed
involved_in translation	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasm	HDA more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
part_of cytosolic large ribosomal subunit	IBA Inferred from Biological aspect of Ancestor more info
part_of cytosolic large ribosomal subunit	IDA Inferred from Direct Assay more info	PubMed
part_of large ribosomal subunit	IEA Inferred from Electronic Annotation more info
part_of preribosome, large subunit precursor	IDA Inferred from Direct Assay more info	PubMed
part_of ribonucleoprotein complex	IEA Inferred from Electronic Annotation more info
located_in ribosome	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: ribosomal 60S subunit protein L17A

NP_012741.1

Ribosomal 60S subunit protein L17A; required for processing of 27SB pre-rRNA and formation of stable 66S assembly intermediates; copurifies with the Dam1 complex (aka DASH complex); homologous to mammalian ribosomal protein L17 and bacterial L22; RPL17A has a paralog, RPL17B, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001143.9 Reference assembly

Range

109269..110129

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001179746.1 → NP_012741.1 TPA: ribosomal 60S subunit protein L17A [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_012741.1

Status: REVIEWED

UniProtKB/Swiss-Prot

D6VX21, P05740

UniProtKB/TrEMBL

A6ZZE6, B3LQS6, C7GJ30, C8ZBZ5, G2WHL3, N1P132

Conserved Domains (1) summary

PTZ00178
Location:1 → 178

PTZ00178; 60S ribosomal protein L17; Provisional