URA1 dihydroorotate dehydrogenase [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: URA1
Official Full Name: dihydroorotate dehydrogenase
Primary source: SGD:S000001699
Locus tag: YKL216W
See related: AllianceGenome:SGD:S000001699; FungiDB:YKL216W; VEuPathDB:YKL216W
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Enables dihydroorotate dehydrogenase activity. Involved in 'de novo' pyrimidine nucleobase biosynthetic process. Located in cytoplasm. Human ortholog(s) of this gene implicated in postaxial acrofacial dysostosis. Orthologous to human DHODH (dihydroorotate dehydrogenase (quinone)). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See URA1 in Genome Data Viewer

Location:: chromosome: XI

Exon count:: 1

Sequence:: Chromosome: XI; NC_001143.9 (25215..26159)

Chromosome XI - NC_001143.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001143.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Mot1-mediated activation of URA1 transcription involves at least two steps, one of which is the removal of TBP bound to the promoter in the opposite orientation required for URA1 transcription.
Title: Function and structural organization of Mot1 bound to a natural target promoter.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables dihydroorotate dehydrogenase (fumarate) activity	IEA Inferred from Electronic Annotation more info
enables dihydroorotate dehydrogenase activity	IBA Inferred from Biological aspect of Ancestor more info
enables dihydroorotate dehydrogenase activity	IDA Inferred from Direct Assay more info	PubMed
enables dihydroorotate dehydrogenase activity	IEA Inferred from Electronic Annotation more info
enables dihydroorotate dehydrogenase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables oxidoreductase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in 'de novo' UMP biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in 'de novo' pyrimidine nucleobase biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in 'de novo' pyrimidine nucleobase biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
involved_in 'de novo' pyrimidine nucleobase biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in 'de novo' pyrimidine nucleobase biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in UMP biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in pyrimidine nucleotide biosynthetic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: dihydroorotate dehydrogenase

NP_012706.1

EC 1.3.98.1

Dihydroorotate dehydrogenase; catalyzes the fourth enzymatic step in the de novo biosynthesis of pyrimidines, converting dihydroorotic acid into orotic acid

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001143.9 Reference assembly

Range

25215..26159

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001179781.1 → NP_012706.1 TPA: dihydroorotate dehydrogenase [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_012706.1

Status: REVIEWED

UniProtKB/Swiss-Prot

D6VWY7, P28272, Q2XN75, Q70DC7

UniProtKB/TrEMBL

B5VLU9, C7GIZ7, G2WHH8, N1NZQ4

Conserved Domains (1) summary

PRK02506
Location:4 → 314

PRK02506; dihydroorotate dehydrogenase 1A; Reviewed