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    AIM23 Aim23p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 853310, updated on 9-Dec-2024

    Summary

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    Official Symbol
    AIM23
    Official Full Name
    Aim23p
    Primary source
    SGD:S000003667
    Locus tag
    YJL131C
    See related
    AllianceGenome:SGD:S000003667; FungiDB:YJL131C; VEuPathDB:YJL131C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    MIF3
    Summary
    Enables mitochondrial ribosome binding activity. Involved in mitochondrial translational initiation. Located in mitochondrion. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See AIM23 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    1
    Sequence:
    Chromosome: X; NC_001142.9 (164278..165348, complement)

    Chromosome X - NC_001142.9Genomic Context describing neighboring genes Neighboring gene Fe(2+) transporter Neighboring gene uncharacterized protein Neighboring gene bifunctional carbamoylphosphate synthetase/aspartate transcarbamylase Neighboring gene Trk1p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001142.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Evolutionary and genetic analyses of mitochondrial translation initiation factors identify the missing mitochondrial IF3 in S. cerevisiae. Atkinson GC, et al. Nucleic Acids Res, 2012 Jul. PMID 22457064, Free PMC Article
    2. Mitochondrial translation initiation machinery: conservation and diversification. Kuzmenko A, et al. Biochimie, 2014 May. PMID 23954798, Free PMC Article
    3. Aim-less translation: loss of Saccharomyces cerevisiae mitochondrial translation initiation factor mIF3/Aim23 leads to unbalanced protein synthesis. Kuzmenko A, et al. Sci Rep, 2016 Jan 5. PMID 26728900, Free PMC Article
    4. Biological and Evolutionary Significance of Terminal Extensions of Mitochondrial Translation Initiation Factor 3. Derbikova K, et al. Int J Mol Sci, 2018 Dec 4. PMID 30518034, Free PMC Article
    5. 60S dynamic state of bacterial ribosome is fixed by yeast mitochondrial initiation factor 3. Levitskii S, et al. PeerJ, 2018. PMID 30245939, Free PMC Article

    See all (34) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Yeast Mitochondrial Translation Initiation Factor 3 Interacts with Pet111p to Promote COX2 mRNA Translation.
      Title: Yeast Mitochondrial Translation Initiation Factor 3 Interacts with Pet111p to Promote COX2 mRNA Translation.
    2. Phylogenetic and in vivo complementation analyses reveal that an uncharacterized S. cerevisiae mitochondrial protein currently named Aim23p is a bona fide evolutionary and functional orthologue of mitochondrial IF3.
      Title: Evolutionary and genetic analyses of mitochondrial translation initiation factors identify the missing mitochondrial IF3 in S. cerevisiae.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables mitochondrial ribosome binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables translation initiation factor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in mitochondrial translational initiation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in mitochondrial translational initiation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in mitochondrion HDA PubMed 
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Aim23p
    NP_012404.1
    • Mitochondrial translation initiation factor 3 (IF3, mIF3); evolutionarily conserved; interacts with mitochondrial ribosomal small subunit; binds to E. coli ribosomes in vitro; null mutant displays severe respiratory growth defect and elevated frequency of mitochondrial genome loss

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001142.9 Reference assembly

      Range
      164278..165348 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001181564.1 → NP_012404.1  TPA: Aim23p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_012404.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A6ZQJ9, B5VL46, C7GPZ8, C8ZB86, D6VW54, P47015
      UniProtKB/TrEMBL
      G2WGP0
      Conserved Domains (1) summary
      pfam14877
      Location:93 → 260
      mIF3; Mitochondrial translation initiation factor
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P47015.1

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