HGF hepatocyte growth factor [Homo sapiens (human)] - Gene

Summary

Official Symbol: HGFprovided by HGNC
Official Full Name: hepatocyte growth factorprovided by HGNC
Primary source: HGNC:HGNC:4893
See related: Ensembl:ENSG00000019991 MIM:142409; AllianceGenome:HGNC:4893
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: SF; HGFB; HPTA; F-TCF; DFNB39
Summary: This gene encodes a protein that binds to the hepatocyte growth factor receptor to regulate cell growth, cell motility and morphogenesis in numerous cell and tissue types. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate alpha and beta chains, which form the mature heterodimer. This protein is secreted by mesenchymal cells and acts as a multi-functional cytokine on cells of mainly epithelial origin. This protein also plays a role in angiogenesis, tumorogenesis, and tissue regeneration. Although the encoded protein is a member of the peptidase S1 family of serine proteases, it lacks peptidase activity. Mutations in this gene are associated with nonsyndromic hearing loss. [provided by RefSeq, Nov 2015]
Expression: Biased expression in placenta (RPKM 90.6), adrenal (RPKM 7.0) and 2 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 7q21.11

Exon count:: 20

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	7	NC_000007.14 (81699010..81770047, complement)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	7	NC_060931.1 (82951060..83022099, complement)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	7	NC_000007.13 (81328326..81399363, complement)

Chromosome 7 - NC_000007.14 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

A HGF Mutation in the Familial Case of Primary Lymphedema: A Report.
Title: A HGF Mutation in the Familial Case of Primary Lymphedema: A Report.
Differential Immune Checkpoint Protein Expression in HNSCC: The Role of HGF/MET Signaling.
Title: Differential Immune Checkpoint Protein Expression in HNSCC: The Role of HGF/MET Signaling.
Pathogenic variants in HGF give rise to childhood-to-late onset primary lymphoedema by loss of function.
Title: Pathogenic variants in HGF give rise to childhood-to-late onset primary lymphoedema by loss of function.
Superiority of Intestinal Adaptation by Hepatocyte Growth Factor in the Jejunum: An Experimental Study in a Short-Bowel Rat Model.
Title: Superiority of Intestinal Adaptation by Hepatocyte Growth Factor in the Jejunum: An Experimental Study in a Short-Bowel Rat Model.
Circulating TNF-RII, IP-10 and HGF are associated with severity of COVID-19 in oncologic patients.
Title: Circulating TNF-RII, IP-10 and HGF are associated with severity of COVID-19 in oncologic patients.
Hepatocyte Growth Factor Promotes Differentiation Potential and Stress Response of Human Stem Cells from Apical Papilla.
Title: Hepatocyte Growth Factor Promotes Differentiation Potential and Stress Response of Human Stem Cells from Apical Papilla.
HGF facilitates methylation of MEG3, potentially implicated in vemurafenib resistance in melanoma.
Title: HGF facilitates methylation of MEG3, potentially implicated in vemurafenib resistance in melanoma.
Intercellular Interactions Mediated by HGF And TGF-Beta Promote the 3D Spherical and Xenograft Growth of Liver Cancer Cells.
Title: Intercellular Interactions Mediated by HGF And TGF-Β Promote the 3D Spherical and Xenograft Growth of Liver Cancer Cells.
USP11 potentiates HGF/AKT signaling and drives metastasis in hepatocellular carcinoma.
Title: USP11 potentiates HGF/AKT signaling and drives metastasis in hepatocellular carcinoma.
Identification of deleterious nsSNPs in human HGF gene: in silico approach.
Title: Identification of deleterious nsSNPs in human HGF gene: in silico approach.

Submit: New GeneRIF Correction See all GeneRIFs (732)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description	Tests
Autosomal recessive nonsyndromic hearing loss 39 MedGen: C1842342 OMIM: 608265 GeneReviews: Genetic Hearing Loss Overview	Compare labs

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Protein interactions

Protein	Gene	Interaction	Pubs
Envelope surface glycoprotein gp120	env	Scatter factor (SF) attenuates the apoptosis induced by high-doses of HIV-1 gp120 in human mesangial cells (HMC)	PubMed
Vpu	vpu	The gene expression of hepatocyte growth factor (HGF) increases in cells infected with vpu-deficient HIV-1 compared to cells infected with the wild-type virus, indicating that HIV-1 Vpu downregulates HGF protein expression	PubMed

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH47062 (e-PCR)
- UniSTS:75781

G66820 (e-PCR)
- UniSTS:166661

SHGC-31157 (e-PCR)
- UniSTS:24590

STS-AA015815 (e-PCR)
- UniSTS:77839

D7S3046 (e-PCR)
- UniSTS:8215

D7S804 (e-PCR), detects polymorphism
- UniSTS:10017

SHGC-84463 (e-PCR)
- UniSTS:104756

Hgf (e-PCR), detects polymorphism
- UniSTS:256371

D7S644 (e-PCR), detects polymorphism
- UniSTS:39592

Hgf (e-PCR), detects polymorphism
- UniSTS:143341

Hgf (e-PCR), detects polymorphism
- UniSTS:143342

D7S804 (e-PCR), detects polymorphism
- UniSTS:83193

D7S2748 (e-PCR)
- UniSTS:69631

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables chemoattractant activity	IDA Inferred from Direct Assay more info	PubMed
NOT enables endopeptidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables growth factor activity	NAS Non-traceable Author Statement more info	PubMed
enables identical protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
NOT enables serine-type endopeptidase activity	NAS Non-traceable Author Statement more info	PubMed
enables signaling receptor binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in cell chemotaxis	IDA Inferred from Direct Assay more info	PubMed
involved_in cell morphogenesis	IEA Inferred from Electronic Annotation more info
involved_in cellular response to hepatocyte growth factor stimulus	IDA Inferred from Direct Assay more info	PubMed
involved_in epithelial cell proliferation	IEA Inferred from Electronic Annotation more info
involved_in epithelial to mesenchymal transition	TAS Traceable Author Statement more info	PubMed
involved_in hepatocyte growth factor receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in hepatocyte growth factor receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in liver development	IEA Inferred from Electronic Annotation more info
involved_in mitotic cell cycle	NAS Non-traceable Author Statement more info	PubMed
involved_in myoblast proliferation	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of apoptotic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of autophagy	NAS Non-traceable Author Statement more info	PubMed
involved_in negative regulation of extrinsic apoptotic signaling pathway via death domain receptors	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of hydrogen peroxide-mediated programmed cell death	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of inflammatory response	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of interleukin-6 production	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of release of cytochrome c from mitochondria	IDA Inferred from Direct Assay more info	PubMed
involved_in positive chemotaxis	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of DNA biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of MAPK cascade	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of cell migration	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of interleukin-10 production	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of osteoblast differentiation	NAS Non-traceable Author Statement more info	PubMed
involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	NAS Non-traceable Author Statement more info	PubMed
NOT involved_in proteolysis	NAS Non-traceable Author Statement more info	PubMed
acts_upstream_of_or_within regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of p38MAPK cascade	IEA Inferred from Electronic Annotation more info
involved_in skeletal muscle cell proliferation	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in extracellular region	TAS Traceable Author Statement more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	HDA more info	PubMed
located_in platelet alpha granule lumen	TAS Traceable Author Statement more info

General protein information

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Preferred Names: hepatocyte growth factor

Names: fibroblast-derived tumor cytotoxic factor; hepatocyte growth factor (hepapoietin A; scatter factor); hepatopoietin-A; lung fibroblast-derived mitogen

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_016274.2 RefSeqGene

Range

5090..76127

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_000601.6 → NP_000592.3 hepatocyte growth factor isoform 1 preproprotein

See identical proteins and their annotated locations for NP_000592.3

Status: REVIEWED

Description

Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).

Source sequence(s)

AC004960, AV701693, BU533235, BX495370, M29145, M73240

Consensus CDS

CCDS5597.1

UniProtKB/Swiss-Prot

A1L3U6, P14210, Q02935, Q13494, Q14519, Q3KRB2, Q8TCE2, Q9BYL9, Q9BYM0, Q9UDU6

UniProtKB/TrEMBL

A8K6K9

Related

ENSP00000222390.5, ENST00000222390.11

Conserved Domains (4) summary

smart00020
Location:494 → 716

Tryp_SPc; Trypsin-like serine protease

smart00130
Location:210 → 290

KR; Kringle domain

cd00108
Location:388 → 470

KR; Kringle domain; Kringle domains are believed to play a role in binding mediators, such as peptides, other proteins, membranes, or phospholipids. They are autonomous structural domains, found in a varying number of copies, in blood clotting and ...

cd00129
Location:39 → 122

PAN_APPLE; PAN/APPLE-like domain; present in N-terminal (N) domains of plasminogen/ hepatocyte growth factor proteins, plasma prekallikrein/coagulation factor XI and microneme antigen proteins, plant receptor-like protein kinases, and various nematode and leech ...
NM_001010931.3 → NP_001010931.1 hepatocyte growth factor isoform 2 precursor

See identical proteins and their annotated locations for NP_001010931.1

Status: REVIEWED

Description

Transcript Variant: This variant (2) lacks multiple 3' exons but includes an alternate 3' exon, compared to variant 1. The resulting protein (isoform 2) has a shorter and distinct C-terminus, compared to isoform 1. Isoform 2, also named NK2, has been shown to act as a competitive antagonist to active hepatocyte growth factor for the c-Met receptor.

Source sequence(s)

BM971901, BU533235, BX495370, L02931

Consensus CDS

CCDS47627.1

UniProtKB/Swiss-Prot

P14210

Related

ENSP00000389854.2, ENST00000444829.7

Conserved Domains (2) summary

smart00130
Location:210 → 289

KR; Kringle domain

cd00129
Location:39 → 122

PAN_APPLE; PAN/APPLE-like domain; present in N-terminal (N) domains of plasminogen/ hepatocyte growth factor proteins, plasma prekallikrein/coagulation factor XI and microneme antigen proteins, plant receptor-like protein kinases, and various nematode and leech ...
NM_001010932.3 → NP_001010932.1 hepatocyte growth factor isoform 3 preproprotein

See identical proteins and their annotated locations for NP_001010932.1

Status: REVIEWED

Description

Transcript Variant: This variant (3) uses an alternate in-frame splice site in the 5' coding region compared to variant 1. The encoded isoform (3) lacks a portion of the alpha chain and is shorter compared to isoform 1.

Source sequence(s)

AC004960, AV701693, BU533235, BX495370, M73240

Consensus CDS

CCDS47626.1

UniProtKB/TrEMBL

A8K6K9

Related

ENSP00000391238.2, ENST00000457544.7

Conserved Domains (4) summary

smart00020
Location:489 → 711

Tryp_SPc; Trypsin-like serine protease

smart00130
Location:205 → 285

KR; Kringle domain

cd00108
Location:383 → 465

KR; Kringle domain; Kringle domains are believed to play a role in binding mediators, such as peptides, other proteins, membranes, or phospholipids. They are autonomous structural domains, found in a varying number of copies, in blood clotting and ...

cd00129
Location:39 → 122

PAN_APPLE; PAN/APPLE-like domain; present in N-terminal (N) domains of plasminogen/ hepatocyte growth factor proteins, plasma prekallikrein/coagulation factor XI and microneme antigen proteins, plant receptor-like protein kinases, and various nematode and leech ...
NM_001010933.3 → NP_001010933.1 hepatocyte growth factor isoform 4 precursor

See identical proteins and their annotated locations for NP_001010933.1

Status: REVIEWED

Description

Transcript Variant: This variant (4) lacks an internal in-frame segment and multiple 3' exons but includes an alternate 3' exon, compared to variant 1. The resulting protein (isoform 4) lacks an internal segment and has a shorter and distinct C-terminus, compared to isoform 1.

Source sequence(s)

BC022308, BM971901, BU533235, BX495370, L02931

Consensus CDS

CCDS47628.1

UniProtKB/Swiss-Prot

P14210

Related

ENSP00000408270.1, ENST00000453411.6

Conserved Domains (2) summary

smart00130
Location:205 → 284

KR; Kringle domain

cd00129
Location:39 → 122

PAN_APPLE; PAN/APPLE-like domain; present in N-terminal (N) domains of plasminogen/ hepatocyte growth factor proteins, plasma prekallikrein/coagulation factor XI and microneme antigen proteins, plant receptor-like protein kinases, and various nematode and leech ...
NM_001010934.3 → NP_001010934.1 hepatocyte growth factor isoform 5 precursor

See identical proteins and their annotated locations for NP_001010934.1

Status: REVIEWED

Description

Transcript Variant: This variant (5) lacks multiple 3' exons but has an alternate 3' segment, compared to variant 1. The resulting protein (isoform 5) has a distinct and shorter C-terminus, compared to isoform 1.

Source sequence(s)

BC063485, BU533235, BX495370, U46010

Consensus CDS

CCDS47629.1

UniProtKB/TrEMBL

A0A2R8YEI1

Related

ENSP00000413829.2, ENST00000423064.7

Conserved Domains (2) summary

smart00130
Location:126 → 208

KR; Kringle domain

cd00129
Location:39 → 122

PAN_APPLE; PAN/APPLE-like domain; present in N-terminal (N) domains of plasminogen/ hepatocyte growth factor proteins, plasma prekallikrein/coagulation factor XI and microneme antigen proteins, plant receptor-like protein kinases, and various nematode and leech ...