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    OLI1 F0 ATP synthase subunit c [ Saccharomyces cerevisiae S288C ]

    Gene ID: 854584, updated on 9-Dec-2024

    Summary

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    Official Symbol
    OLI1
    Official Full Name
    F0 ATP synthase subunit c
    Primary source
    SGD:S000007274
    Locus tag
    Q0130
    See related
    AllianceGenome:SGD:S000007274; FungiDB:Q0130; VEuPathDB:Q0130
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C, substrain: FY1679)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    ATP9; OLI3
    Summary
    Contributes to ATP hydrolysis activity and proton-transporting ATP synthase activity, rotational mechanism. Involved in proton motive force-driven ATP synthesis. Located in mitochondrion. Part of proton-transporting ATP synthase complex, coupling factor F(o). Human ortholog(s) of this gene implicated in early-onset dystonia and/or spastic paraplegia; renal cell carcinoma; and urinary bladder cancer. Orthologous to human ATP5MC1 (ATP synthase membrane subunit c locus 1); ATP5MC2 (ATP synthase membrane subunit c locus 2); and ATP5MC3 (ATP synthase membrane subunit c locus 3). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See OLI1 in Genome Data Viewer
    Sequence:
    Chromosome: MT; NC_001224.1 (46723..46953)

    Chromosome MT - NC_001224.1Genomic Context describing neighboring genes Neighboring gene tRNA-Glu Neighboring gene cytochrome b mRNA maturase bI2 Neighboring gene cytochrome b mRNA maturase bI3 Neighboring gene intron-encoded RNA maturase bI4 Neighboring gene cytochrome b Neighboring gene tRNA-Ser Neighboring gene mitochondrial 37S ribosomal protein VAR1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001224.1

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Biogenesis of mitochondria 36, The genetic and biochemical analysis of a mitochondrially determined cold sensitive oligomycin resistant mutant of Saccharomyces cerevisiae with affected mitochondrial ATPase assembly. Trembath MK, et al. Mol Gen Genet, 1975 Nov 3. PMID 129672
    2. oli1 Transcripts in wild type and in a cytoplasmic "petite" mutant of yeast. Thalenfeld BE, et al. J Biol Chem, 1983 Dec 10. PMID 6315719
    3. Amino acid substitutions in subunit 9 of the mitochondrial ATPase complex of Saccharomyces cerevisiae. Sequence analysis of a series of revertants of an oli1 mit- mutant carrying an amino acid substitution in the hydrophilic loop of subunit 9. Willson TA, et al. Eur J Biochem, 1987 Sep 1. PMID 2957197
    4. Biogenesis of mitochondria: a mutation in the 5'-untranslated region of yeast mitochondrial oli1 mRNA leading to impairment in translation of subunit 9 of the mitochondrial ATPase complex. Ooi BG, et al. Nucleic Acids Res, 1987 Mar 11. PMID 2951651, Free PMC Article
    5. DNA sequence analysis of the oli1 gene reveals amino acid changes in mitochondrial ATPase subunit 9 from oligomycin-resistant mutants of Saccharomyces cerevisiae. Ooi BG, et al. Eur J Biochem, 1985 Nov 4. PMID 2932333

    See all (76) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Allotopic expression of COX6 elucidates Atco-driven co-assembly of cytochrome oxidase and ATP synthase.
      Title: Allotopic expression of COX6 elucidates Atco-driven co-assembly of cytochrome oxidase and ATP synthase.
    2. Data indicate cardiolipin interacts with the c10-ring in the ATP synthase from Saccharomyces cerevisiae .
      Title: Cardiolipin binds selectively but transiently to conserved lysine residues in the rotor of metazoan ATP synthases.
    3. rotor component assembly of yeast mitochondrial ATP synthase is enhanced when Atp9p is supplied by Atp9p-Cox6p complexes
      Title: Assembly of the rotor component of yeast mitochondrial ATP synthase is enhanced when Atp9p is supplied by Atp9p-Cox6p complexes.
    4. ATP9B is able to exit the ER and localize to the TGN independently of CDC50 proteins and this protein contains a Golgi localization signal in its N-terminal cytoplasmic region
      Title: ATP9B, a P4-ATPase (a putative aminophospholipid translocase), localizes to the trans-Golgi network in a CDC50 protein-independent manner.
    5. report a new nuclear gene, designated ATP25 (reading frame YMR098C on chromosome XIII), required for expression of Atp9p (subunit 9) of the mitochondrial proton translocating ATPase
      Title: ATP25, a new nuclear gene of Saccharomyces cerevisiae required for expression and assembly of the Atp9p subunit of mitochondrial ATPase.
    6. presequence either targets Atp6p to the Atp9p or signals insertion of the Atp6p precursor into a microcompartment of the membrane for more efficient interaction with the Atp9p ring.
      Title: The leader peptide of yeast Atp6p is required for efficient interaction with the Atp9p ring of the mitochondrial ATPase.
    7. a mutation in mitochondrial F(1)F(0)-ATP synthase prevents the synthesis of the two mtDNA-encoded subunits (Atp6p and Atp9p) forming the core of this channel
      Title: A "petite obligate" mutant of Saccharomyces cerevisiae: functional mtDNA is lethal in cells lacking the delta subunit of mitochondrial F1-ATPase.
    8. by directly interacting with newly synthesized Atp9 in a posttranslational manner, Oxa1 is required to maintain the assembly competence of the Atp9-F(1)-subcomplex for its association with Atp6
      Title: Oxa1 directly interacts with Atp9 and mediates its assembly into the mitochondrial F1Fo-ATP synthase complex.
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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    contributes_to ATP hydrolysis activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables lipid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables proton transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    contributes_to proton-transporting ATP synthase activity, rotational mechanism IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in proton motive force-driven ATP synthesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in proton motive force-driven ATP synthesis IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in proton motive force-driven ATP synthesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in proton transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrial membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion HDA PubMed 
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of proton-transporting ATP synthase complex, coupling factor F(o) IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of proton-transporting ATP synthase complex, coupling factor F(o) IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of proton-transporting ATP synthase complex, coupling factor F(o) IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    F0 ATP synthase subunit c
    NP_009319.1
    • F0-ATP synthase subunit c (ATPase-associated proteolipid); encoded on the mitochondrial genome; mutation confers oligomycin resistance; expression is specifically dependent on the nuclear genes AEP1 and AEP2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001224.1 Reference assembly

      Range
      46723..46953
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_009319.1 F0 ATP synthase subunit c (mitochondrion) [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_009319.1

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      A0A0A7P075, P00841, P61829, Q37750
      UniProtKB/TrEMBL
      A0A0G3F489, A7LCN9, C7GM63, E9PA19, E9PA20, G2HKE8
      Conserved Domains (1) summary
      cd18182
      Location:8 → 72
      ATP-synt_Fo_c_ATP5G3; ATP synthase F(0) complex subunit C3 (ATP5G3) and similar proteins
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P61829.1

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