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    BI4 intron-encoded RNA maturase bI4 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 854582, updated on 9-Dec-2024

    Summary

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    Official Symbol
    BI4
    Official Full Name
    intron-encoded RNA maturase bI4
    Primary source
    SGD:S000007273
    Locus tag
    Q0120
    See related
    AllianceGenome:SGD:S000007273; FungiDB:Q0120; VEuPathDB:Q0120
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C, substrain: FY1679)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables RNA binding activity. Involved in Group I intron splicing and mitochondrial mRNA processing. Located in mitochondrion. Human ortholog(s) of this gene implicated in ovarian carcinoma and urinary bladder cancer. Orthologous to human MT-CYB (mitochondrially encoded cytochrome b). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See BI4 in Genome Data Viewer
    Sequence:
    Chromosome: MT; NC_001224.1 (36540..42251)

    Chromosome MT - NC_001224.1Genomic Context describing neighboring genes Neighboring gene F1F0 ATP synthase subunit a Neighboring gene tRNA-Glu Neighboring gene cytochrome b mRNA maturase bI2 Neighboring gene cytochrome b mRNA maturase bI3 Neighboring gene cytochrome b Neighboring gene tRNA-Ser Neighboring gene F0 ATP synthase subunit c

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001224.1

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Synthesis and function of the mitochondrial intron--encoded bI4 RNA maturase from Saccharomyces cerevisiae. Effects of upstream frame-shift mutations. Goguel V, et al. Curr Genet, 1989 Oct. PMID 2560681
    2. A mitochondrial RNA maturase gene transferred to the yeast nucleus can control mitochondrial mRNA splicing. Banroques J, et al. Cell, 1986 Sep 12. PMID 2875797
    3. Efficient splicing of two yeast mitochondrial introns controlled by a nuclear-encoded maturase. Banroques J, et al. EMBO J, 1987 Apr. PMID 3036491, Free PMC Article
    4. Connections between RNA splicing and DNA intron mobility in yeast mitochondria: RNA maturase and DNA endonuclease switching experiments. Goguel V, et al. Mol Cell Biol, 1992 Feb. PMID 1310149, Free PMC Article
    5. Novel hybrid maturases in unstable pseudorevertants of maturaseless mutants of yeast mitochondrial DNA. Anziano PQ, et al. Nucleic Acids Res, 1990 Jun 11. PMID 1972561, Free PMC Article

    See all (24) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables RNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables endonuclease activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in Group I intron splicing IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in Group I intron splicing IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in RNA splicing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mitochondrial electron transport, ubiquinol to cytochrome c IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitochondrial mRNA processing IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in proton transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    intron-encoded RNA maturase bI4
    NP_009316.1
    • Mitochondrial mRNA maturase; forms a complex with Nam2p to mediate splicing of the bI4 intron of the COB gene; encoded by both exon and intron sequences of partially processed COB mRNA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001224.1 Reference assembly

      Range
      36540..42251
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_009316.1 intron-encoded RNA maturase bI4 (mitochondrion) [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_009316.1

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      A0A0A7NYH9, P03879, Q02324, Q9ZZW6
      UniProtKB/TrEMBL
      G2HKE5
      Conserved Domains (4) summary
      COG1372
      Location:363 → 592
      Hop; Intein/homing endonuclease [Replication, recombination and repair, Mobilome: prophages, transposons]
      cd00284
      Location:8 → 207
      Cytochrome_b_N; Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria, ...
      pfam00961
      Location:408 → 495
      LAGLIDADG_1; LAGLIDADG endonuclease
      cl00193
      Location:208 → 255
      cytochrome_b_C; Cytochrome b(C-terminus)/b6/petD: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria, ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P03879.2

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