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    AI3 intron-encoded DNA endonuclease aI3 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 854595, updated on 9-Dec-2024

    Summary

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    Official Symbol
    AI3
    Official Full Name
    intron-encoded DNA endonuclease aI3
    Primary source
    SGD:S000007263
    Locus tag
    Q0060
    See related
    AllianceGenome:SGD:S000007263; FungiDB:Q0060; VEuPathDB:Q0060
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C, substrain: FY1679)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables endonuclease activity. Predicted to be involved in aerobic respiration and respiratory electron transport chain. Predicted to be located in mitochondrion. Predicted to be part of respiratory chain complex IV. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See AI3 in Genome Data Viewer
    Sequence:
    Chromosome: MT; NC_001224.1 (13818..19996)

    Chromosome MT - NC_001224.1Genomic Context describing neighboring genes Neighboring gene 15S ribosomal RNA Neighboring gene tRNA-Trp Neighboring gene intron-encoded DNA endonuclease aI5 alpha Neighboring gene cytochrome c oxidase subunit 1 Neighboring gene intron-encoded reverse transcriptase aI1 Neighboring gene intron-encoded reverse transcriptase aI2 Neighboring gene intron-encoded DNA endonuclease aI4 Neighboring gene intron-encoded DNA endonuclease aI5 beta Neighboring gene F1F0 ATP synthase subunit 8

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001224.1

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. I-Sce III an intron-encoded DNA endonuclease from yeast mitochondria. Asymmetrical DNA binding properties and cleavage reaction. Schapira M, et al. Nucleic Acids Res, 1993 Aug 11. PMID 8367285, Free PMC Article
    2. Two homologous introns from related Saccharomyces species differ in their mobility. Szczepanek T, et al. Gene, 1994 Feb 11. PMID 8112577
    3. The mobile group I intron 3 alpha of the yeast mitochondrial COXI gene encodes a 35-kDa processed protein that is an endonuclease but not a maturase. Guo WW, et al. J Biol Chem, 1995 Jun 30. PMID 7797552
    4. Splice site selection by intron aI3 of the COX1 gene from Saccharomyces cerevisiae. Winter AJ, et al. Nucleic Acids Res, 1992 Aug 11. PMID 1324471, Free PMC Article
    5. Indication for deletion of two introns in the oxi-3 gene of a respiratory-competent Saccharomyces cerevisiae strain. Mink M. Biochem Genet, 1988 Aug. PMID 3067726

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    contributes_to cytochrome-c oxidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables cytochrome-c oxidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables endonuclease activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables endonuclease activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables heme binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in RNA splicing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in aerobic respiration IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in aerobic respiration IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in intron homing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in proton transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in respiratory electron transport chain IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion TAS
    Traceable Author Statement
    more info
    		 PubMed 
    part_of respiratory chain complex IV IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    intron-encoded DNA endonuclease aI3
    NP_009308.2
    • Endonuclease I-SceIII; encoded by a mobile group I intron within the mitochondrial COX1 gene

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001224.1 Reference assembly

      Range
      13818..19996
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_009308.2 intron-encoded DNA endonuclease aI3 (mitochondrion) [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_009308.2

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      A0A0A7P044, P03877, Q35790, Q9ZZX3
      UniProtKB/TrEMBL
      A0A0H3WJP7
      Conserved Domains (2) summary
      pfam00961
      Location:113 → 209
      LAGLIDADG_1; LAGLIDADG endonuclease
      cl00275
      Location:9 → 81
      Heme_Cu_Oxidase_I; Heme-copper oxidase subunit I. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which catalyze the reduction of O2 and simultaneously pump protons across the membrane. The superfamily is ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P03877.3

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