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    SMU2 Smu2p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 854645, updated on 17-Dec-2024

    Summary

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    Official Symbol
    SMU2
    Official Full Name
    Smu2p
    Primary source
    SGD:S000001423
    Locus tag
    YIL161W
    See related
    AllianceGenome:SGD:S000001423; FungiDB:YIL161W; VEuPathDB:YIL161W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Involved in nonfunctional rRNA decay. Is active in cytoplasm. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See SMU2 in Genome Data Viewer
    Location:
    chromosome: IX
    Exon count:
    1
    Sequence:
    Chromosome: IX; NC_001141.2 (39433..40140)

    Chromosome IX - NC_001141.2Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene beta-fructofuranosidase SUC2 Neighboring gene acetyl-CoA C-acyltransferase Neighboring gene formin BNR1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001141.2

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Sensing of individual stalled 80S ribosomes by Fap1 for nonfunctional rRNA turnover. Li S, et al. Mol Cell, 2022 Sep 15. PMID 36113412
    2. Scp160p associates with specific mRNAs in yeast. Li AM, et al. Nucleic Acids Res, 2003 Apr 1. PMID 12654998, Free PMC Article
    3. Srs2 and Sgs1 DNA helicases associate with Mre11 in different subcomplexes following checkpoint activation and CDK1-mediated Srs2 phosphorylation. Chiolo I, et al. Mol Cell Biol, 2005 Jul. PMID 15964827, Free PMC Article
    4. Identification of Saccharomyces cerevisiae spindle pole body remodeling factors. Greenland KB, et al. PLoS One, 2010 Nov 12. PMID 21103054, Free PMC Article
    5. Unligated Okazaki Fragments Induce PCNA Ubiquitination and a Requirement for Rad59-Dependent Replication Fork Progression. Nguyen HD, et al. PLoS One, 2013. PMID 23824283, Free PMC Article

    See all (30) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables protein binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in nonfunctional rRNA decay IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Smu2p
    NP_012105.1
    • Protein involved in removal of stalled, decoding-defective ribosomes; acts as cofactor for Fap1p, along with Fpr1p, increasing the efficiency of Rps3p polyubiquitination on stalled monosomes and the subsequent decay of nonfunctional 18S rRNA; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; mRNA is enriched in Scp160p-associated mRNPs; non-essential gene

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001141.2 Reference assembly

      Range
      39433..40140
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001179509.1 → NP_012105.1  TPA: Smu2p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_012105.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VVC5, P40449
      UniProtKB/TrEMBL
      G2WFZ0, N1P4E7
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P40449.1

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