U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    VRG4 GDP-mannose transporter [ Saccharomyces cerevisiae S288C ]

    Gene ID: 852647, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    VRG4
    Official Full Name
    GDP-mannose transporter
    Primary source
    SGD:S000003193
    Locus tag
    YGL225W
    See related
    AllianceGenome:SGD:S000003193; FungiDB:YGL225W; VEuPathDB:YGL225W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    GOG5; LDB3; VAN2; VIG4
    Summary
    Enables GDP-mannose transmembrane transporter activity. Involved in GDP-mannose transmembrane transport. Located in Golgi apparatus. Orthologous to human TMEM241 (transmembrane protein 241). [provided by Alliance of Genome Resources, Dec 2024]
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See VRG4 in Genome Data Viewer
    Location:
    chromosome: VII
    Exon count:
    1
    Sequence:
    Chromosome: VII; NC_001139.9 (76894..77907)

    Chromosome VII - NC_001139.9Genomic Context describing neighboring genes Neighboring gene Mtc3p Neighboring gene tRNA-Val Neighboring gene nucleotidase Neighboring gene Golgi transport complex subunit COG1

    Genomic regions, transcripts, and products

    Go to the top of the page Help
    Genomic Sequence:
    NC_001139.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. The yeast VRG4 gene is required for normal Golgi functions and defines a new family of related genes. Poster JB, et al. J Biol Chem, 1996 Feb 16. PMID 8632002
    2. Structural basis for substrate specificity and regulation of nucleotide sugar transporters in the lipid bilayer. Parker JL, et al. Nat Commun, 2019 Oct 11. PMID 31604945, Free PMC Article
    3. Molecular characterization of Vig4/Vrg4 GDP-mannose transporter of the yeast Saccharomyces cerevisiae. Abe M, et al. FEBS Lett, 1999 Sep 24. PMID 10570930
    4. Distinct protein domains of the yeast Golgi GDP-mannose transporter mediate oligomer assembly and export from the endoplasmic reticulum. Gao XD, et al. J Biol Chem, 2000 Jun 9. PMID 10748175
    5. Identification of a conserved motif in the yeast golgi GDP-mannose transporter required for binding to nucleotide sugar. Gao XD, et al. J Biol Chem, 2001 Feb 9. PMID 11067855

    See all (46) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables GDP-mannose transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GDP-mannose transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables GDP-mannose transmembrane transporter activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables antiporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in GDP-mannose transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in GDP-mannose transmembrane transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in Golgi apparatus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in Golgi apparatus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in Golgi membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasmic vesicle IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasmic vesicle membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion HDA PubMed 

    General protein information

    Go to the top of the page Help
    Preferred Names
    GDP-mannose transporter
    NP_011290.1
    • Golgi GDP-mannose transporter; regulates Golgi function and glycosylation in Golgi; VRG4 has a paralog, HVG1, that arose from the whole genome duplication

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001139.9 Reference assembly

      Range
      76894..77907
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001181090.1 → NP_011290.1  TPA: GDP-mannose transporter [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_011290.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A6ZTW6, B3LHR7, C7GUZ7, C8Z830, D6VVB0, P40107
      UniProtKB/TrEMBL
      G2WDN6, N1P2D2
      Conserved Domains (1) summary
      COG5070
      Location:15 → 337
      VRG4; Nucleotide-sugar transporter [Carbohydrate transport and metabolism / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P40107.1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
    Molecular Biology Databases
    Research Materials
    Tools