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    RSC8 Rsc8p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 850598, updated on 9-Dec-2024

    Summary

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    Official Symbol
    RSC8
    Official Full Name
    Rsc8p
    Primary source
    SGD:S000001933
    Locus tag
    YFR037C
    See related
    AllianceGenome:SGD:S000001933; FungiDB:YFR037C; VEuPathDB:YFR037C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    SWH3
    Summary
    Enables DNA binding activity. Involved in double-strand break repair via nonhomologous end joining; nucleosome disassembly; and transcription elongation by RNA polymerase II. Located in nucleus. Part of RSC-type complex. Human ortholog(s) of this gene implicated in Coffin-Siris syndrome 8 and hydrocephalus. Orthologous to human SMARCC1 (SWI/SNF related, matrix associated, actin dependent regulator of chromatin subfamily c member 1) and SMARCC2 (SWI/SNF related, matrix associated, actin dependent regulator of chromatin subfamily c member 2). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See RSC8 in Genome Data Viewer
    Location:
    chromosome: VI
    Exon count:
    1
    Sequence:
    Chromosome: VI; NC_001138.5 (227513..229186, complement)

    Chromosome VI - NC_001138.5Genomic Context describing neighboring genes Neighboring gene tRNA-Lys Neighboring gene anaphase promoting complex subunit CDC26 Neighboring gene putative ATPase Neighboring gene Osw7p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001138.5

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. SWI2/SNF2 and related proteins: ATP-driven motors that disrupt protein-DNA interactions? Pazin MJ, et al. Cell, 1997 Mar 21. PMID 9118215
    2. RSC-dependent constructive and destructive interference between opposing arrays of phased nucleosomes in yeast. Ganguli D, et al. Genome Res, 2014 Oct. PMID 25015381, Free PMC Article
    3. Temporal sequence and cell cycle cues in the assembly of host factors at the yeast 2 micron plasmid partitioning locus. Ma CH, et al. Nucleic Acids Res, 2013 Feb 1. PMID 23275556, Free PMC Article
    4. Structure and function of the SWIRM domain, a conserved protein module found in chromatin regulatory complexes. Da G, et al. Proc Natl Acad Sci U S A, 2006 Feb 14. PMID 16461455, Free PMC Article
    5. The SWIRM domain: a conserved module found in chromosomal proteins points to novel chromatin-modifying activities. Aravind L, et al. Genome Biol, 2002 Jul 24. PMID 12186646, Free PMC Article

    See all (135) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. identification of Rsc8 and Rsc30, subunits of the Saccharomyces cerevisiae chromatin remodeling complex RSC, as novel NHEJ factors
      Title: The yeast chromatin remodeler RSC complex facilitates end joining repair of DNA double-strand breaks.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding RCA
    inferred from Reviewed Computational Analysis
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in chromatin organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in double-strand break repair via nonhomologous end joining IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in double-strand break repair via nonhomologous end joining IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in nucleosome disassembly IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of DNA-templated transcription IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in transcription elongation by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of RSC-type complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of SWI/SNF complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus HDA PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Rsc8p
    NP_116695.3
    • Component of the RSC chromatin remodeling complex; essential for viability and mitotic growth; homolog of SWI/SNF subunit Swi3p, but unlike Swi3p, does not activate transcription of reporters

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001138.5 Reference assembly

      Range
      227513..229186 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001180002.3 → NP_116695.3  TPA: Rsc8p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_116695.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VTS0, P43609, Q6B289
      UniProtKB/TrEMBL
      B3LUP8, C8Z7X3, G2WDH8, N1P3A7
      Conserved Domains (1) summary
      COG5259
      Location:26 → 557
      RSC8; RSC chromatin remodeling complex subunit RSC8 [Chromatin structure and dynamics / Transcription]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P43609.1

    Gene LinkOut

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