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    GAL83 Gal83p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 856749, updated on 9-Dec-2024

    Summary

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    Official Symbol
    GAL83
    Official Full Name
    Gal83p
    Primary source
    SGD:S000000829
    Locus tag
    YER027C
    See related
    AllianceGenome:SGD:S000000829; FungiDB:YER027C; VEuPathDB:YER027C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    SPM1
    Summary
    Contributes to AMP-activated protein kinase activity. Involved in several processes, including cell adhesion; invasive growth in response to glucose limitation; and regulation of protein-containing complex assembly. Located in cytoplasm and nuclear envelope lumen. Part of nucleotide-activated protein kinase complex. Orthologous to several human genes including PRKAB2 (protein kinase AMP-activated non-catalytic subunit beta 2). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See GAL83 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    1
    Sequence:
    Chromosome: V; NC_001137.3 (208979..210232, complement)

    Chromosome V - NC_001137.3Genomic Context describing neighboring genes Neighboring gene tRNA-His Neighboring gene CDP-diacylglycerol-serine O-phosphatidyltransferase Neighboring gene Mig3p Neighboring gene mRNA splicing protein SMB1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001137.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Multi-omic characterization of laboratory-evolved Saccharomyces cerevisiae HJ7-14 with high ability of algae-based ethanol production. Kim SJ, et al. Appl Microbiol Biotechnol, 2018 Oct. PMID 30121750
    2. SIP1 is a catabolite repression-specific negative regulator of GAL gene expression. Mylin LM, et al. Genetics, 1994 Jul. PMID 8088514, Free PMC Article
    3. Mutations in the gal83 glycogen-binding domain activate the snf1/gal83 kinase pathway by a glycogen-independent mechanism. Wiatrowski HA, et al. Mol Cell Biol, 2004 Jan. PMID 14673168, Free PMC Article
    4. Recessive mutations conferring resistance to carbon catabolite repression of galactokinase synthesis in Saccharomyces cerevisiae. Matsumoto K, et al. J Bacteriol, 1983 Mar. PMID 6337998, Free PMC Article
    5. The beta-subunits of the Snf1 kinase in Saccharomyces cerevisiae, Gal83 and Sip2, but not Sip1, are redundant in glucose derepression and regulation of sterol biosynthesis. Zhang J, et al. Mol Microbiol, 2010 Jul. PMID 20545859

    See all (91) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Data show that Gal83, the most abundant beta subunit of the AMP-activated serine/threonine-protein kinase catalytic subunit SNF1 (Snf1) complex, plays a major role in SNF1-mediated downregulation of the unfolded protein response (UPR) pathway.
      Title: Expression control of the AMPK regulatory subunit and its functional significance in yeast ER stress response.
    2. Reg1 protein regulates phosphorylation of all three Snf1 isoforms but preferentially associates with the Gal83 isoform
      Title: Reg1 protein regulates phosphorylation of all three Snf1 isoforms but preferentially associates with the Gal83 isoform.
    3. Gal83 is the most important isoform not only for the growth on non-fermentable carbon sources, but also for regulation of ergosterol biosynthetic genes.
      Title: The beta-subunits of the Snf1 kinase in Saccharomyces cerevisiae, Gal83 and Sip2, but not Sip1, are redundant in glucose derepression and regulation of sterol biosynthesis.
    4. catalytically inactive Snf1 promotes the cytoplasmic retention of Gal83 in glucose-grown cells through its interaction with the C terminus of Gal83
      Title: Regulation of the nucleocytoplasmic distribution of Snf1-Gal83 protein kinase.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    contributes_to AMP-activated protein kinase activity IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    contributes_to AMP-activated protein kinase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables protein kinase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in cell adhesion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in invasive growth in response to glucose limitation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of protein-containing complex assembly IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in signal transduction IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nuclear envelope lumen IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of nucleotide-activated protein kinase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of nucleotide-activated protein kinase complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of nucleotide-activated protein kinase complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Gal83p
    NP_010944.1
    • One of three alternate beta-subunits of the Snf1 kinase complex; allows nuclear localization of the Snf1 kinase complex in the presence of a nonfermentable carbon source; necessary and sufficient for phosphorylation of the Mig2p transcription factor in response to alkaline stress; functionally redundant with SIP1 and SIP2 for the phosphorylation of Mig1p in response to glucose deprivation; contains a glycogen-binding domain

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001137.3 Reference assembly

      Range
      208979..210232 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001178918.1 → NP_010944.1  TPA: Gal83p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_010944.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D3DLS6, Q04739
      UniProtKB/TrEMBL
      G2WCR0, N1P7I9
      Conserved Domains (2) summary
      smart01010
      Location:306 → 416
      AMPKBI; 5'-AMP-activated protein kinase beta subunit, interation domain
      pfam16561
      Location:163 → 247
      AMPK1_CBM; Glycogen recognition site of AMP-activated protein kinase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q04739.1

    Gene LinkOut

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