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    YCP4 flavodoxin-like fold family protein [ Saccharomyces cerevisiae S288C ]

    Gene ID: 850360, updated on 9-Dec-2024

    Summary

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    Official Symbol
    YCP4
    Official Full Name
    flavodoxin-like fold family protein
    Primary source
    SGD:S000000597
    Locus tag
    YCR004C
    See related
    AllianceGenome:SGD:S000000597; FungiDB:YCR004C; VEuPathDB:YCR004C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Predicted to enable FMN binding activity and NAD(P)H dehydrogenase (quinone) activity. Acts upstream of or within positive regulation of ferroptosis. Located in eisosome and plasma membrane. Is active in cytoplasm. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See YCP4 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    1
    Sequence:
    Chromosome: III; NC_001135.5 (119575..120318, complement)

    Chromosome III - NC_001135.5Genomic Context describing neighboring genes Neighboring gene septin CDC10 Neighboring gene mitochondrial 54S ribosomal protein YmL32 Neighboring gene citrate (Si)-synthase CIT2 Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001135.5

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Disruption of YCP4 enhances freeze-thaw tolerance in Saccharomyces cerevisiae. Kim HS. Biotechnol Lett, 2022 Mar. PMID 35124760
    2. The Saccharomyces cerevisiae flavodoxin-like proteins Ycp4 and Rfs1 play a role in stress response and in the regulation of genes related to metabolism. Cardona F, et al. Arch Microbiol, 2011 Jul. PMID 21442317
    3. Redox regulation of the tumor suppressor PTEN by glutaredoxin 5 and Ycp4. Kim Y, et al. Biochem Biophys Res Commun, 2011 Apr 1. PMID 21371429
    4. Six new candidate members of the alpha/beta twisted open-sheet family detected by sequence similarity to flavodoxin. Grandori R, et al. Protein Sci, 1994 Dec. PMID 7756978, Free PMC Article
    5. Ferroptosis-protective membrane domains in quiescence. Megarioti AH, et al. Cell Rep, 2023 Dec 26. PMID 38096056

    See all (50) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Disruption of YCP4 enhances freeze-thaw tolerance in Saccharomyces cerevisiae.
      Title: Disruption of YCP4 enhances freeze-thaw tolerance in Saccharomyces cerevisiae.
    2. YCP4 and RFS1 have a clear role in the regulation of metabolism at the late stages of growth.
      Title: The Saccharomyces cerevisiae flavodoxin-like proteins Ycp4 and Rfs1 play a role in stress response and in the regulation of genes related to metabolism.
    3. These results suggest that the reduction of oxidized hPTEN is regulated by Grx5 and Ycp4.
      Title: Redox regulation of the tumor suppressor PTEN by glutaredoxin 5 and Ycp4.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables FMN binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables NAD(P)H dehydrogenase (quinone) activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within positive regulation of ferroptosis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cell periphery HDA PubMed 
    located_in cytoplasm HDA PubMed 
    is_active_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in eisosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane raft IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion HDA PubMed 
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane HDA PubMed 
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    flavodoxin-like fold family protein
    NP_009930.1
    • hypothetical protein; has sequence and structural similarity to flavodoxins; predicted to be palmitoylated; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001135.5 Reference assembly

      Range
      119575..120318 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001178717.1 → NP_009930.1  TPA: flavodoxin-like fold family protein [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_009930.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VR14, P25349
      UniProtKB/TrEMBL
      A6ZTI6, B3LU76, B5VEV2, C7GQL7, C8Z489, G2WA22, N1P814
      Conserved Domains (1) summary
      cl00438
      Location:1 → 201
      FMN_red; NADPH-dependent FMN reductase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P25349.1

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