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    TSC3 Tsc3p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 852350, updated on 9-Dec-2024

    Summary

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    Official Symbol
    TSC3
    Official Full Name
    Tsc3p
    Primary source
    SGD:S000007521
    Locus tag
    YBR058C-A
    See related
    AllianceGenome:SGD:S000007521; FungiDB:YBR058C-A; VEuPathDB:YBR058C-A
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables enzyme activator activity. Involved in 3-keto-sphinganine metabolic process and positive regulation of sphingolipid biosynthetic process. Located in endoplasmic reticulum. Part of serine palmitoyltransferase complex. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See TSC3 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    1
    Sequence:
    Chromosome: II; NC_001134.8 (356324..356566, complement)

    Chromosome II - NC_001134.8Genomic Context describing neighboring genes Neighboring gene Mum2p Neighboring gene ubiquitin-specific protease UBP14 Neighboring gene serine/threonine protein kinase AKL1 Neighboring gene origin recognition complex subunit 2

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001134.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Mutations in the Lcb2p subunit of serine palmitoyltransferase eliminate the requirement for the TSC3 gene in Saccharomyces cerevisiae. Monaghan E, et al. Yeast, 2002 Jun 15. PMID 12185836
    2. Tsc3 regulates SPT amino acid choice in Saccharomyces cerevisiae by promoting alanine in the sphingolipid pathway. Ren J, et al. J Lipid Res, 2018 Nov. PMID 30154231, Free PMC Article
    3. Collaborative regulation of yeast SPT-Orm2 complex by phosphorylation and ceramide. Xie T, et al. Cell Rep, 2024 Feb 27. PMID 38285738
    4. Tsc3p is an 80-amino acid protein associated with serine palmitoyltransferase and required for optimal enzyme activity. Gable K, et al. J Biol Chem, 2000 Mar 17. PMID 10713067
    5. Structure of the ceramide-bound SPOTS complex. Schäfer JH, et al. Nat Commun, 2023 Oct 4. PMID 37794019, Free PMC Article

    See all (39) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables enzyme activator activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables enzyme activator activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in 3-keto-sphinganine metabolic process IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    involved_in positive regulation of sphingolipid biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in endoplasmic reticulum HDA PubMed 
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of serine palmitoyltransferase complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Tsc3p
    NP_116327.3
    • Protein that stimulates the activity of serine palmitoyltransferase; involved in sphingolipid biosynthesis; Lcb1p and Lcb2p are the two components of serine palmitoyltransferase

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001134.8 Reference assembly

      Range
      356324..356566 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001184442.3 → NP_116327.3  TPA: Tsc3p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_116327.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VQ58, Q3E790
      UniProtKB/TrEMBL
      A6ZL03, B3LN90, C7GQH4, D3UEF6, G2W964
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q3E790.1

    Gene LinkOut

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