EXO84 exocyst subunit EXO84 [Saccharomyces cerevisiae S288C] - Gene

Summary

Go to the top of the page Help

Official Symbol: EXO84
Official Full Name: exocyst subunit EXO84
Primary source: SGD:S000000306
Locus tag: YBR102C
See related: AllianceGenome:SGD:S000000306; FungiDB:YBR102C; VEuPathDB:YBR102C
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as: USA3
Summary: Involved in Golgi to plasma membrane transport; exocyst localization; and protein-containing complex assembly. Located in cellular bud neck; cellular bud tip; and incipient cellular bud site. Part of exocyst. Orthologous to human EXOC8 (exocyst complex component 8). [provided by Alliance of Genome Resources, Dec 2024]
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help

See EXO84 in Genome Data Viewer

Location:: chromosome: II

Exon count:: 1

Sequence:: Chromosome: II; NC_001134.8 (445062..447323, complement)

Chromosome II - NC_001134.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:: NC_001134.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Mitotic phosphorylation of Exo84 disrupted the assembly of the exocyst complex, thereby affecting exocytosis and cell surface expansion.
Title: Mitotic phosphorylation of Exo84 disrupts exocyst assembly and arrests cell growth.
The structure of the exocyst subunit Exo84p is presented.
Title: The structures of exocyst subunit Exo70p and the Exo84p C-terminal domains reveal a common motif.
exocyst component Exo84p plays a critical role in both the assembly of the exocyst and its targeting to sites of secretion
Title: The critical role of Exo84p in the organization and polarized localization of the exocyst complex.

Submit: New GeneRIF Correction

Pathways from PubChem

Go to the top of the page

Interactions

Go to the top of the page Help

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

Go to the top of the page Help

Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables molecular_function	ND No biological Data available more info

Process	Evidence Code	Pubs
involved_in Golgi to plasma membrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in Golgi to plasma membrane transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in exocyst assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in exocyst localization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in exocytosis	IEA Inferred from Electronic Annotation more info
involved_in exocytosis	IGI Inferred from Genetic Interaction more info	PubMed
involved_in exocytosis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein localization	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein transport	IEA Inferred from Electronic Annotation more info
involved_in spliceosomal complex assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in spliceosomal complex assembly	IPI Inferred from Physical Interaction more info	PubMed

Component	Evidence Code	Pubs
located_in cellular bud	IEA Inferred from Electronic Annotation more info
located_in cellular bud neck	IDA Inferred from Direct Assay more info	PubMed
located_in cellular bud neck	IEA Inferred from Electronic Annotation more info
located_in cellular bud tip	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasmic vesicle	IEA Inferred from Electronic Annotation more info
part_of exocyst	IBA Inferred from Biological aspect of Ancestor more info
part_of exocyst	IDA Inferred from Direct Assay more info	PubMed
part_of exocyst	IEA Inferred from Electronic Annotation more info
located_in incipient cellular bud site	IDA Inferred from Direct Assay more info	PubMed
located_in mating projection tip	HDA more info	PubMed
located_in prospore membrane	HDA more info	PubMed
located_in transport vesicle	IEA Inferred from Electronic Annotation more info

General protein information

Go to the top of the page Help

Preferred Names: exocyst subunit EXO84

NP_009660.1

Exocyst subunit with dual roles in exocytosis and spliceosome assembly; subunit of the the exocyst complex which mediates polarized targeting and tethering of post-Golgi secretory vesicles to active sites of exocytosis at the plasma membrane (PM) prior to SNARE-mediated fusion; required for exocyst assembly and targeting of the complex to specific sites on the bud tip PM; associates the U1 snRNP; role in pre-mRNA splicing and prespliceosome formation; possible Cdc28 substrate

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001134.8 Reference assembly

Range

445062..447323 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001178450.1 → NP_009660.1 TPA: exocyst subunit EXO84 [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_009660.1

Status: REVIEWED

UniProtKB/Swiss-Prot

D6VQA1, P38261

UniProtKB/TrEMBL

A6ZL47, B3LN51, G2W9A7, N1P6L6

Conserved Domains (4) summary

pfam05109
Location:19 → 181

Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)

pfam08700
Location:177 → 259

Vps51; Vps51/Vps67

pfam16528
Location:534 → 738

Exo84_C; Exocyst component 84 C-terminal

cl17171
Location:340 → 444

PH-like; Pleckstrin homology-like domain