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    non-specific serine/threonine protein kinase [ Saccharomyces cerevisiae S288C ]

    Gene ID: 855953, updated on 9-Dec-2024

    Summary

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    Official Full Name
    non-specific serine/threonine protein kinase
    Primary source
    SGD:S000006071
    Locus tag
    YPL150W
    See related
    AllianceGenome:SGD:S000006071; FungiDB:YPL150W; VEuPathDB:YPL150W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables protein kinase activity. Involved in protein phosphorylation. Located in cytoplasmic ribonucleoprotein granule. Orthologous to human MELK (maternal embryonic leucine zipper kinase). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    Location:
    chromosome: XVI
    Exon count:
    1
    Sequence:
    Chromosome: XVI; NC_001148.4 (268188..270893)

    Chromosome XVI - NC_001148.4Genomic Context describing neighboring genes Neighboring gene peptidylprolyl isomerase RRD2 Neighboring gene mRNA splicing protein PRP46 Neighboring gene Atg5p Neighboring gene holo-[acyl-carrier-protein] synthase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001148.4

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Analysis of yeast protein kinases using protein chips. Zhu H, et al. Nat Genet, 2000 Nov. PMID 11062466
    2. Protein kinases are associated with multiple, distinct cytoplasmic granules in quiescent yeast cells. Shah KH, et al. Genetics, 2014 Dec. PMID 25342717, Free PMC Article
    3. Multilayered regulation of TORC1-body formation in budding yeast. Sullivan A, et al. Mol Biol Cell, 2019 Feb 1. PMID 30485160, Free PMC Article
    4. Substrate specificity analysis of protein kinase complex Dbf2-Mob1 by peptide library and proteome array screening. Mah AS, et al. BMC Biochem, 2005 Oct 21. PMID 16242037, Free PMC Article
    5. Systematic identification of the genes affecting glycogen storage in the yeast Saccharomyces cerevisiae: implication of the vacuole as a determinant of glycogen level. Wilson WA, et al. Mol Cell Proteomics, 2002 Mar. PMID 12096123

    See all (43) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables 3-phosphoinositide-dependent protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables AMP-activated protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-dependent protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables Rho-dependent protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables eukaryotic translation initiation factor 2alpha kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2AS1 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2AS121 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2AT120 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2AXS139 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2BS14 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2BS36 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3S10 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3S28 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3S57 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3T11 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3T3 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3T45 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3T6 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H4S1 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein kinase activity HDA PubMed 
    enables protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ribosomal protein S6 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in chromatin remodeling IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein phosphorylation HDA PubMed 
    Component Evidence Code Pubs
    located_in cytoplasmic ribonucleoprotein granule IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    non-specific serine/threonine protein kinase
    NP_015175.1
    • Protein kinase of unknown cellular role; binds phosphatidylinositols and cardiolipin in a large-scale study

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001148.4 Reference assembly

      Range
      268188..270893
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001183964.1 → NP_015175.1  TPA: non-specific serine/threonine protein kinase [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_015175.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W3L9, Q12152
      UniProtKB/TrEMBL
      A6ZWA4, B3LKS8, B5VT20, C7GJA1, C8ZIM9, G2WP33, N1NX12
      Conserved Domains (1) summary
      cd14003
      Location:40 → 286
      STKc_AMPK-like; Catalytic domain of AMP-activated protein kinase-like Serine/Threonine Kinases
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q12152.1

    Gene LinkOut

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