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    MET7 tetrahydrofolate synthase [ Saccharomyces cerevisiae S288C ]

    Gene ID: 854415, updated on 9-Dec-2024

    Summary

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    Official Symbol
    MET7
    Official Full Name
    tetrahydrofolate synthase
    Primary source
    SGD:S000005767
    Locus tag
    YOR241W
    See related
    AllianceGenome:SGD:S000005767; FungiDB:YOR241W; VEuPathDB:YOR241W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    MET23
    Summary
    Enables tetrahydrofolylpolyglutamate synthase activity. Involved in one-carbon metabolic process. Located in mitochondrion. Orthologous to human FPGS (folylpolyglutamate synthase). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See MET7 in Genome Data Viewer
    Location:
    chromosome: XV
    Exon count:
    1
    Sequence:
    Chromosome: XV; NC_001147.6 (786995..788641)

    Chromosome XV - NC_001147.6Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene tRNA(Thr) (cytosine(32)-N(3))-methyltransferase Neighboring gene Ssp2p Neighboring gene pseudouridine synthase PUS7

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001147.6

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Polyglutamylation of folate coenzymes is necessary for methionine biosynthesis and maintenance of intact mitochondrial genome in Saccharomyces cerevisiae. Cherest H, et al. J Biol Chem, 2000 May 12. PMID 10799479
    2. A bifunctional dihydrofolate synthetase--folylpolyglutamate synthetase in Plasmodium falciparum identified by functional complementation in yeast and bacteria. Salcedo E, et al. Mol Biochem Parasitol, 2001 Feb. PMID 11223131
    3. Disruption of cytoplasmic and mitochondrial folylpolyglutamate synthetase activity in Saccharomyces cerevisiae. DeSouza L, et al. Arch Biochem Biophys, 2000 Apr 15. PMID 10775416
    4. Epigenetics Identifier screens reveal regulators of chromatin acylation and limited specificity of acylation antibodies. Kollenstart L, et al. Sci Rep, 2021 Jun 17. PMID 34140538, Free PMC Article
    5. Telomere length kinetics assay (TELKA) sorts the telomere length maintenance (tlm) mutants into functional groups. Rubinstein L, et al. Nucleic Acids Res, 2014 Jun. PMID 24728996, Free PMC Article

    See all (40) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Inactivation of folylpolyglutamate synthetase Met7 results in genome instability driven by an increased dUTP/dTTP ratio.
      Title: Inactivation of folylpolyglutamate synthetase Met7 results in genome instability driven by an increased dUTP/dTTP ratio.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables acid-amino acid ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables tetrahydrofolylpolyglutamate synthase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables tetrahydrofolylpolyglutamate synthase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables tetrahydrofolylpolyglutamate synthase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in folic acid-containing compound biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in one-carbon metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in one-carbon metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in tetrahydrofolylpolyglutamate biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in tetrahydrofolylpolyglutamate biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum HDA PubMed 
    located_in mitochondrial inner membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrial matrix IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    tetrahydrofolate synthase
    NP_014884.1
    • Folylpolyglutamate synthetase; catalyzes extension of the glutamate chains of the folate coenzymes, required for methionine synthesis and for maintenance of mitochondrial DNA; protein abundance increases in response to DNA replication stress

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001147.6 Reference assembly

      Range
      786995..788641
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001183660.1 → NP_014884.1  TPA: tetrahydrofolate synthase [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_014884.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A6ZP80, B3LJR0, B5VSC3, C8ZGZ3, D6W2U3, E7KIA3, E7KUJ4, E7QKX4, Q08645
      Conserved Domains (1) summary
      TIGR01499
      Location:100 → 542
      folC; folylpolyglutamate synthase/dihydrofolate synthase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q08645.1

    Gene LinkOut

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