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    LPL1 putative hydrolase [ Saccharomyces cerevisiae S288C ]

    Gene ID: 854225, updated on 9-Dec-2024

    Summary

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    Official Symbol
    LPL1
    Official Full Name
    putative hydrolase
    Primary source
    SGD:S000005585
    Locus tag
    YOR059C
    See related
    AllianceGenome:SGD:S000005585; FungiDB:YOR059C; VEuPathDB:YOR059C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    YOR29-10
    Summary
    Enables lysophospholipase activity. Involved in lipid homeostasis. Located in lipid droplet. Orthologous to human FAM135B (family with sequence similarity 135 member B). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See LPL1 in Genome Data Viewer
    Location:
    chromosome: XV
    Exon count:
    1
    Sequence:
    Chromosome: XV; NC_001147.6 (438906..440258, complement)

    Chromosome XV - NC_001147.6Genomic Context describing neighboring genes Neighboring gene Ase1p Neighboring gene tRNA-Lys Neighboring gene Sld7p Neighboring gene casein kinase 2 catalytic subunit CKA2

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001147.6

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Identification of a phospholipase B encoded by the LPL1 gene in Saccharomyces cerevisiae. Selvaraju K, et al. Biochim Biophys Acta, 2014 Oct. PMID 25014274
    2. The phosphorylation of a kinetochore protein Dam1 by Aurora B/Ipl1 kinase promotes chromosome bipolar attachment in yeast. Jin F, et al. Sci Rep, 2017 Sep 19. PMID 28928489, Free PMC Article
    3. Mobilization of steryl esters from lipid particles of the yeast Saccharomyces cerevisiae. Wagner A, et al. Biochim Biophys Acta, 2009 Feb. PMID 19111628
    4. Phospholipase Lpl1 links lipid droplet function with quality control protein degradation. Weisshaar N, et al. Mol Biol Cell, 2017 Mar 15. PMID 28100635, Free PMC Article
    5. Disorder in CENP-A(Cse4) tail-chaperone interaction facilitates binding with Ame1/Okp1 at the kinetochore. Shukla S, et al. Structure, 2024 Jun 6. PMID 38565139

    See all (31) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. regulation of Dam1 phosphorylation imposed by Ipl1 kinase is critical for faithful chromosome segregation.
      Title: The phosphorylation of a kinetochore protein Dam1 by Aurora B/Ipl1 kinase promotes chromosome bipolar attachment in yeast.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables calcium-dependent phospholipase A2 activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables calcium-independent phospholipase A2 activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables lysophospholipase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables lysophospholipase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables lysophospholipase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables monoacylglycerol lipase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables phospholipase A2 activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in lipid catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in lipid homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in lipid metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in endoplasmic reticulum HDA PubMed 
    is_active_in lipid droplet IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in lipid droplet IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in lipid droplet IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    putative hydrolase
    NP_014702.1
    • Phospholipase; contains lipase specific GXSXG motif; maintains lipid droplet (LD) morphology; induced by transcription factor Rpn4p; protein abundance increases in response to DNA replication stress

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001147.6 Reference assembly

      Range
      438906..440258 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001183478.1 → NP_014702.1  TPA: putative hydrolase [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_014702.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W2C2, O00022, Q08448
      UniProtKB/TrEMBL
      A6ZNR1, B5VRV7, C7GX59, C8ZI20, G2WMT7, N1NWV9
      Conserved Domains (1) summary
      pfam05057
      Location:5 → 209
      DUF676; Putative serine esterase (DUF676)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q08448.1

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