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    YSP3 putative subtilisin-like protease YSP3 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 854164, updated on 9-Dec-2024

    Summary

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    Official Symbol
    YSP3
    Official Full Name
    putative subtilisin-like protease YSP3
    Primary source
    SGD:S000005529
    Locus tag
    YOR003W
    See related
    AllianceGenome:SGD:S000005529; FungiDB:YOR003W; VEuPathDB:YOR003W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Predicted to enable serine-type endopeptidase activity. Predicted to be involved in protein catabolic process in the vacuole. Located in endoplasmic reticulum and fungal-type vacuole lumen. Human ortholog(s) of this gene implicated in familial hypercholesterolemia and hypobetalipoproteinemia. Orthologous to human PCSK9 (proprotein convertase subtilisin/kexin type 9). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See YSP3 in Genome Data Viewer
    Location:
    chromosome: XV
    Exon count:
    1
    Sequence:
    Chromosome: XV; NC_001147.6 (331455..332891)

    Chromosome XV - NC_001147.6Genomic Context describing neighboring genes Neighboring gene exosome nuclease subunit RRP6 Neighboring gene dolichyl-P-Glc:Man(9)GlcNAc(2)-PP-dolichol alpha-1,3-glucosyltransferase Neighboring gene rRNA-binding ribosome biosynthesis protein UTP23 Neighboring gene DNA ligase (ATP) DNL4

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001147.6

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The sequence of a 30 kb fragment on the left arm of chromosome XV from Saccharomyces cerevisiae reveals 15 open reading frames, five of which correspond to previously identified genes. Sterky F, et al. Yeast, 1996 Sep. PMID 8896276
    2. Cloning and characterization of PRB1, a Candida albicans gene encoding a putative novel endoprotease B and factors affecting its expression. Orozco I, et al. Res Microbiol, 2002 Nov. PMID 12455710
    3. Analysis of the vacuolar luminal proteome of Saccharomyces cerevisiae. Sarry JE, et al. FEBS J, 2007 Aug. PMID 17651441
    4. Essential Function of Mec1, the Budding Yeast ATM/ATR Checkpoint-Response Kinase, in Protein Homeostasis. Corcoles-Saez I, et al. Dev Cell, 2018 Aug 20. PMID 30130531
    5. Association of yeast Upf1p with direct substrates of the NMD pathway. Johansson MJ, et al. Proc Natl Acad Sci U S A, 2007 Dec 26. PMID 18087042, Free PMC Article

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables serine-type endopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables serine-type endopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables serine-type endopeptidase activity ISA
    Inferred from Sequence Alignment
    more info
    		 PubMed 
    enables serine-type peptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in protein catabolic process in the vacuole ISA
    Inferred from Sequence Alignment
    more info
    		 PubMed 
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in endoplasmic reticulum HDA PubMed 
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in fungal-type vacuole lumen HDA PubMed 

    General protein information

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    Preferred Names
    putative subtilisin-like protease YSP3
    NP_014645.1
    • Putative precursor of the subtilisin-like protease III; SWAT-GFP and mCherry fusion proteins localize to the endoplasmic reticulum; YSP3 has a paralog, PRB1, that arose from the whole genome duplication

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001147.6 Reference assembly

      Range
      331455..332891
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001183422.1 → NP_014645.1  TPA: putative subtilisin-like protease YSP3 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_014645.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W269, P25036
      UniProtKB/TrEMBL
      B3LJ58, B5VRQ5, C7GJV0, G2WMN3
      Conserved Domains (3) summary
      cd04077
      Location:178 → 451
      Peptidases_S8_PCSK9_ProteinaseK_like; Peptidase S8 family domain in ProteinaseK-like proteins
      COG1404
      Location:79 → 434
      AprE; Serine protease, subtilisin family [Posttranslational modification, protein turnover, chaperones]
      pfam05922
      Location:70 → 167
      Inhibitor_I9; Peptidase inhibitor I9
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P25036.2

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