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    PSF3 DNA replication protein PSF3 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 854019, updated on 9-Dec-2024

    Summary

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    Official Symbol
    PSF3
    Official Full Name
    DNA replication protein PSF3
    Primary source
    SGD:S000005506
    Locus tag
    YOL146W
    See related
    AllianceGenome:SGD:S000005506; FungiDB:YOL146W; VEuPathDB:YOL146W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Involved in DNA-templated DNA replication and double-strand break repair via break-induced replication. Part of CMG complex; GINS complex; and replication fork protection complex. Used to study Meier-Gorlin syndrome. Orthologous to human GINS3 (GINS complex subunit 3). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See PSF3 in Genome Data Viewer
    Location:
    chromosome: XV
    Exon count:
    1
    Sequence:
    Chromosome: XV; NC_001147.6 (48864..49448)

    Chromosome XV - NC_001147.6Genomic Context describing neighboring genes Neighboring gene Spt20p Neighboring gene Pex11p Neighboring gene Ctr9p Neighboring gene Nop8p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001147.6

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Functional proteomic identification of DNA replication proteins by induced proteolysis in vivo. Kanemaki M, et al. Nature, 2003 Jun 12. PMID 12768207
    2. Ctf4 Links DNA Replication with Sister Chromatid Cohesion Establishment by Recruiting the Chl1 Helicase to the Replisome. Samora CP, et al. Mol Cell, 2016 Aug 4. PMID 27397686, Free PMC Article
    3. Targeting the Genome-Stability Hub Ctf4 by Stapled-Peptide Design. Wu Y, et al. Angew Chem Int Ed Engl, 2017 Oct 9. PMID 28815832
    4. GINS, a novel multiprotein complex required for chromosomal DNA replication in budding yeast. Takayama Y, et al. Genes Dev, 2003 May 1. PMID 12730134, Free PMC Article
    5. Efficient initiation of DNA replication in eukaryotes requires Dpb11/TopBP1-GINS interaction. Tanaka S, et al. Mol Cell Biol, 2013 Jul. PMID 23629628, Free PMC Article

    See all (52) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA replication IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in DNA-templated DNA replication IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in double-strand break repair via break-induced replication IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mitotic DNA replication initiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of CMG complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of DNA replication preinitiation complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    part_of GINS complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of GINS complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of replication fork protection complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    DNA replication protein PSF3
    NP_014495.2
    • Subunit of the GINS complex (Sld5p, Psf1p, Psf2p, Psf3p); complex is localized to DNA replication origins and implicated in assembly of the DNA replication machinery

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001147.6 Reference assembly

      Range
      48864..49448
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001183400.1 → NP_014495.2  TPA: DNA replication protein PSF3 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_014495.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W1S3, Q12146
      UniProtKB/TrEMBL
      A6ZN66, B3LIS1, C7GV21, G2WM92
      Conserved Domains (1) summary
      COG5138
      Location:1 → 194
      COG5138; Uncharacterized conserved protein [Function unknown]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q12146.2

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