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    MER1 Mer1p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 855511, updated on 9-Dec-2024

    Summary

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    Official Symbol
    MER1
    Official Full Name
    Mer1p
    Primary source
    SGD:S000005154
    Locus tag
    YNL210W
    See related
    AllianceGenome:SGD:S000005154; FungiDB:YNL210W; VEuPathDB:YNL210W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables U1 snRNP binding activity and mRNA binding activity. Involved in positive regulation of mRNA splicing, via spliceosome and reciprocal meiotic recombination. Located in nucleus. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See MER1 in Genome Data Viewer
    Location:
    chromosome: XIV
    Exon count:
    1
    Sequence:
    Chromosome: XIV; NC_001146.8 (250931..251743)

    Chromosome XIV - NC_001146.8Genomic Context describing neighboring genes Neighboring gene Vid27p Neighboring gene Mrx7p Neighboring gene Hsp70 family ATPase SSB2 Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001146.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Yeast mer1 mutants display reduced levels of meiotic recombination. Engebrecht J, et al. Genetics, 1989 Feb. PMID 2659434, Free PMC Article
    2. MER1, a yeast gene required for chromosome pairing and genetic recombination, is induced in meiosis. Engebrecht J, et al. Mol Cell Biol, 1990 May. PMID 2183032, Free PMC Article
    3. A subset of Mer1p-dependent introns requires Bud13p for splicing activation and nuclear retention. Scherrer FW Jr, et al. RNA, 2006 Jul. PMID 16738408, Free PMC Article
    4. Binding of a cell-type-specific RNA splicing factor to its target regulatory sequence. Nandabalan K, et al. Mol Cell Biol, 1995 Apr. PMID 7891689, Free PMC Article
    5. Meiotic gene conversion and crossing over: their relationship to each other and to chromosome synapsis and segregation. Engebrecht J, et al. Cell, 1990 Sep 7. PMID 2203538

    See all (27) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Snu56p links pre-mRNA-bound Mer1p to Nam8p in the U1 snRNP
      Title: Snu56p is required for Mer1p-activated meiotic splicing.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables U1 snRNP binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables mRNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in meiotic cell cycle IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of mRNA splicing, via spliceosome IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in reciprocal meiotic recombination IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in reciprocal meiotic recombination IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Mer1p
    NP_014189.1
    • mRNA-binding protein required for meiosis-specific mRNA splicing; required for chromosome pairing and meiotic recombination; Mer1p regulon embraces four essential meiotic pre-mRNAs: REC107, HFM1, AMA1 and SPO22

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001146.8 Reference assembly

      Range
      250931..251743
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001183048.1 → NP_014189.1  TPA: Mer1p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_014189.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W0Y0, P16523
      UniProtKB/TrEMBL
      A6ZRN0, B3LP54, B5VQK2, C7GPE7, C8ZG22, G2WLQ3, N1NX94
      Conserved Domains (1) summary
      cl00098
      Location:188 → 263
      KH-I; K homology (KH) RNA-binding domain, type I
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P16523.1

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