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    LUG1 Lug1p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 851066, updated on 9-Dec-2024

    Summary

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    Official Symbol
    LUG1
    Official Full Name
    Lug1p
    Primary source
    SGD:S000004344
    Locus tag
    YLR352W
    See related
    AllianceGenome:SGD:S000004344; FungiDB:YLR352W; VEuPathDB:YLR352W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Predicted to be involved in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process. Part of SCF ubiquitin ligase complex. Human ortholog(s) of this gene implicated in prostate carcinoma. Orthologous to human SKP2 (S-phase kinase associated protein 2). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See LUG1 in Genome Data Viewer
    Location:
    chromosome: XII
    Exon count:
    1
    Sequence:
    Chromosome: XII; NC_001144.5 (831116..833539)

    Chromosome XII - NC_001144.5Genomic Context describing neighboring genes Neighboring gene sphingolipid homeostasis protein ORM2 Neighboring gene putative hydrolase Neighboring gene Bud8p Neighboring gene sedoheptulose-7-phosphate:D-glyceraldehyde-3-phosphate transaldolase TAL1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001144.5

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Hermes Transposon Mutagenesis Shows [URE3] Prion Pathology Prevented by a Ubiquitin-Targeting Protein: Evidence for Carbon/Nitrogen Assimilation Cross Talk and a Second Function for Ure2p in Saccharomyces cerevisiae. Edskes HK, et al. Genetics, 2018 Jul. PMID 29769283, Free PMC Article
    2. Galactose induction of the GAL1 gene requires conditional degradation of the Mig2 repressor. Lim MK, et al. Biochem J, 2011 May 1. PMID 21323640
    3. Chemical genetics screen for enhancers of rapamycin identifies a specific inhibitor of an SCF family E3 ubiquitin ligase. Aghajan M, et al. Nat Biotechnol, 2010 Jul. PMID 20581845, Free PMC Article
    4. Signal-induced disassembly of the SCF ubiquitin ligase complex by Cdc48/p97. Yen JL, et al. Mol Cell, 2012 Oct 26. PMID 23000173, Free PMC Article
    5. Remodeling of the SCF complex-mediated ubiquitination system by compositional alteration of incorporated F-box proteins. Kato M, et al. Proteomics, 2010 Jan. PMID 19882662

    See all (27) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in protein ubiquitination IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of SCF ubiquitin ligase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of SCF ubiquitin ligase complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Lug1p
    NP_013456.1
    • hypothetical protein with similarity to F-box proteins; interacts with the core SCF ubiquitin ligase complex subunits Skp1p and Cdc53p; LUG1 deletion prevents cells containing the [URE3] prion or lacking Ure2p from growing on glycerol

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001144.5 Reference assembly

      Range
      831116..833539
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001182241.1 → NP_013456.1  TPA: Lug1p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_013456.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VYZ0, Q06479
      UniProtKB/TrEMBL
      B5VNP2, C7GRX7, G2WJH0
      Conserved Domains (1) summary
      sd00034
      Location:215 → 240
      LRR_AMN1; leucine-rich repeat [structural motif]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q06479.1

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