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    Gripap1 GRIP1 associated protein 1 [ Mus musculus (house mouse) ]

    Gene ID: 54645, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Gripap1provided by MGI
    Official Full Name
    GRIP1 associated protein 1provided by MGI
    Primary source
    MGI:MGI:1859616
    See related
    Ensembl:ENSMUSG00000031153 AllianceGenome:MGI:1859616
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Sfc10; GRASP-1; DXImx47e; mKIAA1167
    Summary
    Predicted to enable guanyl-nucleotide exchange factor activity; identical protein binding activity; and ionotropic glutamate receptor binding activity. Involved in regulation of neurotransmitter receptor transport, endosome to postsynaptic membrane. Is active in Schaffer collateral - CA1 synapse and glutamatergic synapse. Is expressed in heart; lung; nervous system; and sensory organ. Orthologous to human GRIPAP1 (GRIP1 associated protein 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in frontal lobe adult (RPKM 16.9), cerebellum adult (RPKM 16.4) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Gripap1 in Genome Data Viewer
    Location:
    X A1.1; X 3.51 cM
    Exon count:
    26
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) X NC_000086.8 (7656009..7686805)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (7789961..7820567)

    Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene SMT3 suppressor of mif two 3 homolog 2, pseudogene (S. cerevisiae) Neighboring gene STARR-seq mESC enhancer starr_46671 Neighboring gene STARR-seq mESC enhancer starr_46672 Neighboring gene transcription factor E3 Neighboring gene predicted gene, 39487 Neighboring gene microRNA 1198 Neighboring gene potassium voltage-gated channel, Shal-related family, member 1 Neighboring gene STARR-seq mESC enhancer starr_46674 Neighboring gene OTU domain containing 5

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. GRASP-1 is a neuronal scaffold protein for the JNK signaling pathway. Ye B, et al. FEBS Lett, 2007 Sep 18. PMID 17761173, Free PMC Article
    2. GRASP1 Regulates Synaptic Plasticity and Learning through Endosomal Recycling of AMPA Receptors. Chiu SL, et al. Neuron, 2017 Mar 22. PMID 28285821, Free PMC Article
    3. Physiological and pathological caspase cleavage of the neuronal RasGEF GRASP-1 as detected using a cleavage site-specific antibody. Ye B, et al. Neuroscience, 2002. PMID 12207967
    4. Neuron specific Rab4 effector GRASP-1 coordinates membrane specialization and maturation of recycling endosomes. Hoogenraad CC, et al. PLoS Biol, 2010 Jan 19. PMID 20098723, Free PMC Article
    5. Disruption of a new forkhead/winged-helix protein, scurfin, results in the fatal lymphoproliferative disorder of the scurfy mouse. Brunkow ME, et al. Nat Genet, 2001 Jan. PMID 11138001

    See all (25) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables guanyl-nucleotide exchange factor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ionotropic glutamate receptor binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in negative regulation of protein localization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of receptor clustering ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in neurotransmitter receptor transport, endosome to postsynaptic membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in neurotransmitter receptor transport, endosome to postsynaptic membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of modification of synaptic structure IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of modification of synaptic structure ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of neurotransmitter receptor transport, endosome to postsynaptic membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of neurotransmitter receptor transport, endosome to postsynaptic membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of neurotransmitter receptor transport, endosome to postsynaptic membrane IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in regulation of neurotransmitter receptor transport, endosome to postsynaptic membrane IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of neurotransmitter receptor transport, endosome to postsynaptic membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of recycling endosome localization within postsynapse IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of recycling endosome localization within postsynapse ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in Schaffer collateral - CA1 synapse IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in Schaffer collateral - CA1 synapse IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    is_active_in Schaffer collateral - CA1 synapse IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    located_in axon IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in dendrite IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in dendrite ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in early endosome membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in extrinsic component of postsynaptic early endosome membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in extrinsic component of postsynaptic early endosome membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in glutamatergic synapse IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in glutamatergic synapse IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in glutamatergic synapse IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    is_active_in glutamatergic synapse IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    is_active_in glutamatergic synapse ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in neuronal cell body ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in postsynaptic recycling endosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in postsynaptic recycling endosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in presynaptic membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in recycling endosome membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    GRIP1-associated protein 1
    Names
    HCMV-interacting protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001290455.2 → NP_001277384.1  GRIP1-associated protein 1 isoform 1

      See identical proteins and their annotated locations for NP_001277384.1

      Status: VALIDATED

      Source sequence(s)
      AL671995
      Consensus CDS
      CCDS72334.1
      UniProtKB/TrEMBL
      A2AEW8
      Related
      ENSMUSP00000111339.3, ENSMUST00000115675.9
      Conserved Domains (1) summary
      pfam07888
      Location:2 → 290
      CALCOCO1; Calcium binding and coiled-coil domain (CALCOCO1) like

    2. NM_001359289.2 → NP_001346218.1  GRIP1-associated protein 1 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AL671995
      Related
      ENSMUST00000132456.8
      Conserved Domains (1) summary
      cl25732
      Location:215 → 560
      SMC_N; RecF/RecN/SMC N terminal domain

    3. NM_001359290.2 → NP_001346219.1  GRIP1-associated protein 1 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AL671995
      Conserved Domains (2) summary
      cl25732
      Location:193 → 480
      SMC_N; RecF/RecN/SMC N terminal domain
      cl26511
      Location:235 → 732
      Neuromodulin_N; Gap junction protein N-terminal region

    4. NM_001359291.2 → NP_001346220.1  GRIP1-associated protein 1 isoform 5

      Status: VALIDATED

      Source sequence(s)
      AL671995
      Conserved Domains (1) summary
      cl25732
      Location:260 → 602
      SMC_N; RecF/RecN/SMC N terminal domain

    5. NM_001359293.2 → NP_001346222.1  GRIP1-associated protein 1 isoform 6

      Status: VALIDATED

      Source sequence(s)
      AL671995
      Consensus CDS
      CCDS90694.1
      UniProtKB/TrEMBL
      A2AEW9
      Related
      ENSMUSP00000099218.4, ENSMUST00000101694.10
      Conserved Domains (2) summary
      TIGR04211
      Location:7 → 108
      SH3_and_anchor; SH3 domain protein
      cl25732
      Location:170 → 540
      SMC_N; RecF/RecN/SMC N terminal domain

    6. NM_001426310.1 → NP_001413239.1  GRIP1-associated protein 1 isoform 7

      Status: VALIDATED

      Source sequence(s)
      AL671995

    7. NM_001426311.1 → NP_001413240.1  GRIP1-associated protein 1 isoform 8

      Status: VALIDATED

      Source sequence(s)
      AL671995

    8. NM_001426312.1 → NP_001413241.1  GRIP1-associated protein 1 isoform 9

      Status: VALIDATED

      Source sequence(s)
      AL671995

    9. NM_001426313.1 → NP_001413242.1  GRIP1-associated protein 1 isoform 10

      Status: VALIDATED

      Source sequence(s)
      AL671995

    10. NM_001426314.1 → NP_001413243.1  GRIP1-associated protein 1 isoform 11

      Status: VALIDATED

      Source sequence(s)
      AL671995

    11. NM_001426315.1 → NP_001413244.1  GRIP1-associated protein 1 isoform 12

      Status: VALIDATED

      Source sequence(s)
      AL671995

    12. NM_001426316.1 → NP_001413245.1  GRIP1-associated protein 1 isoform 13

      Status: VALIDATED

      Source sequence(s)
      AL671995

    13. NM_001426317.1 → NP_001413246.1  GRIP1-associated protein 1 isoform 14

      Status: VALIDATED

      Source sequence(s)
      AL671995

    14. NM_207670.3 → NP_997553.1  GRIP1-associated protein 1 isoform 2

      See identical proteins and their annotated locations for NP_997553.1

      Status: VALIDATED

      Source sequence(s)
      AL671995
      Consensus CDS
      CCDS40844.1
      UniProtKB/Swiss-Prot
      A2AEW7, O35693, Q3T9C3, Q69ZP9, Q8VD04
      Related
      ENSMUSP00000068789.8, ENSMUST00000065932.14
      Conserved Domains (2) summary
      PLN00181
      Location:518 → 708
      PLN00181; protein SPA1-RELATED; Provisional
      TIGR02168
      Location:260 → 602
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000086.8 Reference GRCm39 C57BL/6J

      Range
      7656009..7686805
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006527671.5 → XP_006527734.1  GRIP1-associated protein 1 isoform X3

      Conserved Domains (2) summary
      COG1196
      Location:215 → 585
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      TIGR02168
      Location:7 → 414
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type

    2. XM_036162029.1 → XP_036017922.1  GRIP1-associated protein 1 isoform X7

      Conserved Domains (2) summary
      COG1196
      Location:193 → 480
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      TIGR02168
      Location:38 → 621
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type

    3. XM_036162030.1 → XP_036017923.1  GRIP1-associated protein 1 isoform X13

      Conserved Domains (2) summary
      COG1196
      Location:26 → 365
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      TIGR02168
      Location:244 → 586
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type

    4. XM_006527673.5 → XP_006527736.1  GRIP1-associated protein 1 isoform X5

      Conserved Domains (1) summary
      TIGR02168
      Location:9 → 622
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type

    5. XM_006527680.5 → XP_006527743.1  GRIP1-associated protein 1 isoform X11

      Conserved Domains (2) summary
      COG0419
      Location:142 → 598
      SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
      TIGR04211
      Location:7 → 108
      SH3_and_anchor; SH3 domain protein

    6. XM_006527681.5 → XP_006527744.1  GRIP1-associated protein 1 isoform X18

      Conserved Domains (1) summary
      COG1196
      Location:170 → 515
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

    7. XM_030251402.2 → XP_030107262.1  GRIP1-associated protein 1 isoform X16

      Conserved Domains (2) summary
      COG1196
      Location:148 → 435
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      TIGR02168
      Location:2 → 678
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type

    8. XM_006527683.5 → XP_006527746.1  GRIP1-associated protein 1 isoform X22

      Conserved Domains (3) summary
      PLN00181
      Location:457 → 647
      PLN00181; protein SPA1-RELATED; Provisional
      COG1196
      Location:3 → 320
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      TIGR02168
      Location:199 → 541
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type

    9. XM_017318565.2 → XP_017174054.1  GRIP1-associated protein 1 isoform X8

      Conserved Domains (2) summary
      COG1196
      Location:231 → 601
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      TIGR02169
      Location:54 → 405
      SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type

    10. XM_017318566.2 → XP_017174055.1  GRIP1-associated protein 1 isoform X15

      Conserved Domains (1) summary
      TIGR02168
      Location:276 → 618
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type

    11. XM_006527669.5 → XP_006527732.1  GRIP1-associated protein 1 isoform X1

      Conserved Domains (1) summary
      COG1196
      Location:231 → 601
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

    12. XM_017318570.1 → XP_017174059.1  GRIP1-associated protein 1 isoform X20

      Conserved Domains (2) summary
      COG1196
      Location:231 → 601
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      TIGR02169
      Location:54 → 405
      SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type

    13. XM_006527674.5 → XP_006527737.1  GRIP1-associated protein 1 isoform X6

      Conserved Domains (2) summary
      COG1196
      Location:231 → 576
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      TIGR02169
      Location:53 → 402
      SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type

    14. XM_006527672.5 → XP_006527735.1  GRIP1-associated protein 1 isoform X4

      Conserved Domains (2) summary
      COG1196
      Location:209 → 496
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      TIGR02168
      Location:54 → 637
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type

    15. XM_030251399.2 → XP_030107259.1  GRIP1-associated protein 1 isoform X10

      Conserved Domains (1) summary
      TIGR02168
      Location:260 → 602
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type

    16. XM_006527670.3 → XP_006527733.1  GRIP1-associated protein 1 isoform X2

      Conserved Domains (1) summary
      COG0419
      Location:194 → 650
      SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]

    17. XM_006527676.3 → XP_006527739.1  GRIP1-associated protein 1 isoform X9

      Conserved Domains (1) summary
      COG0419
      Location:158 → 614
      SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]

    18. XM_030251400.1 → XP_030107260.1  GRIP1-associated protein 1 isoform X12

      Conserved Domains (1) summary
      COG1196
      Location:164 → 451
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

    19. XM_006527684.2 → XP_006527747.1  GRIP1-associated protein 1 isoform X25

      Conserved Domains (1) summary
      COG1196
      Location:68 → 438
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

    20. XM_036162032.1 → XP_036017925.1  GRIP1-associated protein 1 isoform X25

      Conserved Domains (1) summary
      COG1196
      Location:68 → 438
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

    RNA

    1. XR_003953015.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8VD04.1 GenPept UniProtKB/Swiss-Prot:Q8VD04

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