Tnfsf4 tumor necrosis factor (ligand) superfamily, member 4 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Tnfsf4provided by MGI
Official Full Name: tumor necrosis factor (ligand) superfamily, member 4provided by MGI
Primary source: MGI:MGI:104511
See related: Ensembl:ENSMUSG00000026700 AllianceGenome:MGI:104511
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Ath1; gp34; Ath-1; Ox40l; TXGP1; CD134L; OX-40L; Tnlg2b; Txgp1l
Summary: Enables tumor necrosis factor receptor binding activity. Involved in several processes, including T cell activation; regulation of gene expression; and regulation of lymphocyte activation. Acts upstream of or within cholesterol metabolic process; inflammatory response; and negative regulation of cytokine production. Predicted to be located in cell surface. Predicted to be active in extracellular space. Is expressed in sensory organ and skeleton. Used to study primary pulmonary hypertension and type 1 diabetes mellitus. Human ortholog(s) of this gene implicated in myocardial infarction. Orthologous to human TNFSF4 (TNF superfamily member 4). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Low expression observed in reference dataset See more
Orthologs: human all
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Genomic context

Location:: 1 H2.1; 1 69.75 cM

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	1	NC_000067.7 (161223009..161245777)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	1	NC_000067.6 (161395438..161418206)

Chromosome 1 - NC_000067.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

OX40L enhances the immunogenicity of dendritic cells and inhibits tumor metastasis in mice.
Title: OX40L enhances the immunogenicity of dendritic cells and inhibits tumor metastasis in mice.
OX40 Ligand-Mannose-Binding Lectin Fusion Protein Induces Potent OX40 Cosignaling in CD4[+] T Cells.
Title: OX40 Ligand-Mannose-Binding Lectin Fusion Protein Induces Potent OX40 Cosignaling in CD4(+) T Cells.
Prolongation of allograft survival by artemisinin treatment is associated with blockade of OX40-OX40L.
Title: Prolongation of allograft survival by artemisinin treatment is associated with blockade of OX40-OX40L.
CD40 Activity on Mesenchymal Cells Negatively Regulates OX40L to Maintain Bone Marrow Immune Homeostasis Under Stress Conditions.
Title: CD40 Activity on Mesenchymal Cells Negatively Regulates OX40L to Maintain Bone Marrow Immune Homeostasis Under Stress Conditions.
IL-10(-/-) Enhances DCs Immunity Against Chlamydia psittaci Infection via OX40L/NLRP3 and IDO/Treg Pathways.
Title: IL-10(-/-) Enhances DCs Immunity Against Chlamydia psittaci Infection via OX40L/NLRP3 and IDO/Treg Pathways.
Induced pluripotent stem cell-derived myeloid cells expressing OX40 ligand amplify antigen-specific T cells in advanced melanoma.
Title: Induced pluripotent stem cell-derived myeloid cells expressing OX40 ligand amplify antigen-specific T cells in advanced melanoma.
ILC3-derived OX40L is essential for homeostasis of intestinal Tregs in immunodeficient mice.
Title: ILC3-derived OX40L is essential for homeostasis of intestinal Tregs in immunodeficient mice.
Th1 responses in vivo require cell-specific provision of OX40L dictated by environmental cues.
Title: Th1 responses in vivo require cell-specific provision of OX40L dictated by environmental cues.
OX40L-JAG1-induced TCR-independent Treg proliferation is a conserved mechanism that can be used to expand lineage-stable Tregs to treat autoimmune diseases.
Title: OX40L-JAG1-Induced Expansion of Lineage-Stable Regulatory T Cells Involves Noncanonical NF-κB Signaling.
Pulmonary group 2 innate lymphoid cells may regulate RSV-induced CD4+T cell expansion and activation via OX40/OX40L interaction. Our results might provide a novel understanding of the underlying mechanisms of respiratory tract diseases mediated by type 2 immunity and be useful to improve the insights and therapies for RSV-induced or RSV-aggravated asthma.
Title: Critical role of OX40/OX40L in ILC2-mediated activation of CD4(+)T cells during respiratory syncytial virus infection in mice.

Submit: New GeneRIF Correction See all GeneRIFs (59)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (6)
QTL (6) 1 citation
Targeted (5) 1 citation

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables cytokine activity	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables tumor necrosis factor receptor binding	IPI Inferred from Physical Interaction more info	PubMed
enables tumor necrosis factor receptor superfamily binding	IBA Inferred from Biological aspect of Ancestor more info
enables tumor necrosis factor receptor superfamily binding	IPI Inferred from Physical Interaction more info	PubMed
enables tumor necrosis factor receptor superfamily binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in CD4-positive, alpha-beta T cell costimulation	IDA Inferred from Direct Assay more info	PubMed
involved_in T cell proliferation	IEA Inferred from Electronic Annotation more info
involved_in T cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in T-helper 2 cell activation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in acute inflammatory response	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in blood vessel development	NAS Non-traceable Author Statement more info	PubMed
involved_in cellular response to lipopolysaccharide	ISO Inferred from Sequence Orthology more info
involved_in cellular response to lipopolysaccharide	ISS Inferred from Sequence or Structural Similarity more info
involved_in cellular response to lipopolysaccharide	NAS Non-traceable Author Statement more info	PubMed
involved_in cellular response to nitrogen dioxide	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellular response to prostaglandin E stimulus	ISO Inferred from Sequence Orthology more info
involved_in cellular response to prostaglandin E stimulus	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within cholesterol metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in defense response to nematode	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in inflammatory response	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within inflammatory response	IPI Inferred from Physical Interaction more info	PubMed
involved_in innate immune response	NAS Non-traceable Author Statement more info	PubMed
involved_in memory T cell activation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of DNA-binding transcription factor activity	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of DNA-templated transcription	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of T cell apoptotic process	IC Inferred by Curator more info	PubMed
involved_in negative regulation of T-helper 1 cell differentiation	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of activation-induced cell death of T cells	IC Inferred by Curator more info	PubMed
acts_upstream_of_or_within negative regulation of cytokine production	IPI Inferred from Physical Interaction more info	PubMed
involved_in negative regulation of extrinsic apoptotic signaling pathway	IC Inferred by Curator more info	PubMed
involved_in negative regulation of interleukin-17 production	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of interleukin-17 production	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of regulatory T cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of type II interferon production	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of B cell activation	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of CD4-positive, alpha-beta T cell costimulation	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of CD4-positive, alpha-beta T cell differentiation	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of T cell costimulation	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of T cell cytokine production	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of T cell migration	NAS Non-traceable Author Statement more info	PubMed
involved_in positive regulation of T cell proliferation	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of T-helper 2 cell activation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of T-helper 2 cell differentiation	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of activated T cell proliferation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of activated T cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of alpha-beta T cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of chemokine production	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of cytokine production	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of immune effector process	TAS Traceable Author Statement more info	PubMed
involved_in positive regulation of immunoglobulin mediated immune response	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of immunoglobulin production	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of inflammatory response	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of inflammatory response	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of interleukin-10 production	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of interleukin-12 production	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of interleukin-13 production	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of interleukin-2 production	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of interleukin-2 production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of interleukin-4 production	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of interleukin-4 production	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of interleukin-4 production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of interleukin-4-dependent isotype switching to IgE isotypes	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of interleukin-6 production	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of interleukin-6 production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of memory T cell activation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of memory T cell differentiation	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of type 2 immune response	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of type 2 immune response	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of type II interferon production	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of type II interferon production	ISO Inferred from Sequence Orthology more info
involved_in regulation of adaptive immune response	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of inflammatory response	IDA Inferred from Direct Assay more info	PubMed
involved_in response to nitrogen dioxide	IDA Inferred from Direct Assay more info	PubMed
involved_in response to virus	IDA Inferred from Direct Assay more info	PubMed
involved_in signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cell surface	ISO Inferred from Sequence Orthology more info
located_in cell surface	ISS Inferred from Sequence or Structural Similarity more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	ISO Inferred from Sequence Orthology more info
located_in extracellular space	ISS Inferred from Sequence or Structural Similarity more info
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: tumor necrosis factor ligand superfamily member 4

Names: OX40 ligand; atherosclerosis 1; tax-transcriptionally activated glycoprotein 1 ligand; tumor necrosis factor ligand 2b

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.