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    Odad1 outer dynein arm docking complex subunit 1 [ Mus musculus (house mouse) ]

    Gene ID: 211535, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Odad1provided by MGI
    Official Full Name
    outer dynein arm docking complex subunit 1provided by MGI
    Primary source
    MGI:MGI:2446120
    See related
    Ensembl:ENSMUSG00000040189 AllianceGenome:MGI:2446120
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Ccdc114
    Summary
    Predicted to be involved in cilium movement and outer dynein arm assembly. Predicted to be located in cilium. Predicted to be part of outer dynein arm and outer dynein arm docking complex. Predicted to be active in axoneme. Is expressed in several structures, including brain; olfactory epithelium; parathyroid gland; reproductive system; and ventral grey horn. Human ortholog(s) of this gene implicated in primary ciliary dyskinesia 20. Orthologous to human ODAD1 (outer dynein arm docking complex subunit 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in testis adult (RPKM 7.8), adrenal adult (RPKM 6.5) and 24 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Odad1 in Genome Data Viewer
    Location:
    7 B3; 7 29.6 cM
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (45572591..45598387)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (45923159..45948963)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene transmembrane protein 143 Neighboring gene STARR-positive B cell enhancer ABC_E8172 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:53178126-53178235 Neighboring gene STARR-positive B cell enhancer ABC_E6547 Neighboring gene STARR-positive B cell enhancer ABC_E873 Neighboring gene epithelial membrane protein 3 Neighboring gene ATP synthase, H+ transporting, mitochondrial F0 complex, subunit g pseudogene Neighboring gene STARR-seq mESC enhancer starr_18859 Neighboring gene predicted gene, 45983 Neighboring gene ATP-binding cassette, sub-family C member 6

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. A CRISPR-based screen for Hedgehog signaling provides insights into ciliary function and ciliopathies. Breslow DK, et al. Nat Genet, 2018 Mar. PMID 29459677, Free PMC Article
    2. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article
    3. The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data. Koscielny G, et al. Nucleic Acids Res, 2014 Jan. PMID 24194600, Free PMC Article
    4. BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain. Pourhaghighi R, et al. Cell Syst, 2020 Apr 22. PMID 32325033, Free PMC Article
    5. Genetic determinants of micronucleus formation in vivo. Adams DJ, et al. Nature, 2024 Mar. PMID 38355793, Free PMC Article

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (3) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in cilium movement IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within cilium movement ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cilium movement ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in outer dynein arm assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in outer dynein arm assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in outer dynein arm assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    is_active_in axoneme IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in axoneme ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cilium ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cilium ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    part_of outer dynein arm ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of outer dynein arm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    part_of outer dynein arm docking complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    outer dynein arm-docking complex subunit 1
    Names
    coiled-coil domain containing 114
    coiled-coil domain-containing protein 114

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001364168.1 → NP_001351097.1  outer dynein arm-docking complex subunit 1 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC149053, AK042062, AK135860, BC100373
      UniProtKB/TrEMBL
      A0A1B0GR16
      Related
      ENSMUSP00000147338.3, ENSMUST00000210039.3
      Conserved Domains (1) summary
      TIGR02169
      Location:24 → 314
      SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type

    2. NM_001364169.2 → NP_001351098.1  outer dynein arm-docking complex subunit 1 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC149053
      UniProtKB/TrEMBL
      A0A1B0GSN0
      Related
      ENSMUSP00000148002.2, ENSMUST00000211367.2

    3. NM_001374632.1 → NP_001361561.1  outer dynein arm-docking complex subunit 1 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC149053
      UniProtKB/TrEMBL
      A0A1B0GR16
      Related
      ENSMUSP00000042772.5, ENSMUST00000038720.8
      Conserved Domains (1) summary
      TIGR02169
      Location:24 → 314
      SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type

    RNA

    1. NR_175373.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC149053

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      45572591..45598387
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006540767.5 → XP_006540830.1  outer dynein arm-docking complex subunit 1 isoform X1

      See identical proteins and their annotated locations for XP_006540830.1

      UniProtKB/TrEMBL
      A0A1B0GR16
      Conserved Domains (2) summary
      TIGR02168
      Location:30 → 317
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam15921
      Location:472 → 564
      CCDC158; Coiled-coil domain-containing protein 158

    2. XM_006540765.5 → XP_006540828.1  outer dynein arm-docking complex subunit 1 isoform X1

      See identical proteins and their annotated locations for XP_006540828.1

      UniProtKB/TrEMBL
      A0A1B0GR16
      Conserved Domains (2) summary
      TIGR02168
      Location:30 → 317
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam15921
      Location:472 → 564
      CCDC158; Coiled-coil domain-containing protein 158

    3. XM_006540772.5 → XP_006540835.1  outer dynein arm-docking complex subunit 1 isoform X5

      Conserved Domains (2) summary
      TIGR02168
      Location:30 → 317
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam15921
      Location:472 → 564
      CCDC158; Coiled-coil domain-containing protein 158

    4. XM_036152876.1 → XP_036008769.1  outer dynein arm-docking complex subunit 1 isoform X9

      Conserved Domains (1) summary
      COG1196
      Location:30 → 307
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

    5. XM_006540769.5 → XP_006540832.1  outer dynein arm-docking complex subunit 1 isoform X3

      Conserved Domains (2) summary
      TIGR02168
      Location:30 → 317
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam15921
      Location:472 → 564
      CCDC158; Coiled-coil domain-containing protein 158

    6. XM_036152875.1 → XP_036008768.1  outer dynein arm-docking complex subunit 1 isoform X7

      Conserved Domains (1) summary
      TIGR02168
      Location:30 → 412
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type

    7. XM_036152873.1 → XP_036008766.1  outer dynein arm-docking complex subunit 1 isoform X4

      UniProtKB/Swiss-Prot
      Q3UX62, Q91WT0
      Conserved Domains (1) summary
      COG1196
      Location:30 → 158
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

    8. XM_006540764.4 → XP_006540827.1  outer dynein arm-docking complex subunit 1 isoform X1

      See identical proteins and their annotated locations for XP_006540827.1

      UniProtKB/TrEMBL
      A0A1B0GR16
      Conserved Domains (2) summary
      TIGR02168
      Location:30 → 317
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam15921
      Location:472 → 564
      CCDC158; Coiled-coil domain-containing protein 158

    9. XM_006540766.4 → XP_006540829.1  outer dynein arm-docking complex subunit 1 isoform X1

      See identical proteins and their annotated locations for XP_006540829.1

      UniProtKB/TrEMBL
      A0A1B0GR16
      Conserved Domains (2) summary
      TIGR02168
      Location:30 → 317
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam15921
      Location:472 → 564
      CCDC158; Coiled-coil domain-containing protein 158

    10. XM_006540768.4 → XP_006540831.1  outer dynein arm-docking complex subunit 1 isoform X2

      UniProtKB/Swiss-Prot
      Q3UX62, Q91WT0
      Related
      ENSMUST00000210867.2
      Conserved Domains (2) summary
      TIGR02169
      Location:4 → 250
      SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type
      pfam15921
      Location:405 → 497
      CCDC158; Coiled-coil domain-containing protein 158

    11. XM_036152874.1 → XP_036008767.1  outer dynein arm-docking complex subunit 1 isoform X4

      UniProtKB/Swiss-Prot
      Q3UX62, Q91WT0
      Conserved Domains (1) summary
      COG1196
      Location:30 → 158
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

    12. XM_006540773.1 → XP_006540836.1  outer dynein arm-docking complex subunit 1 isoform X6

      Conserved Domains (1) summary
      pfam15921
      Location:241 → 333
      CCDC158; Coiled-coil domain-containing protein 158

    RNA

    1. XR_003946431.2 RNA Sequence

    2. XR_004934052.1 RNA Sequence

    3. XR_004934053.1 RNA Sequence

    4. XR_391330.4 RNA Sequence

    5. XR_003946432.2 RNA Sequence

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001033243.2: Suppressed sequence

      Description
      NM_001033243.2: This RefSeq was removed because currently there is insufficient support for the transcript and protein.
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q3UX62.1 GenPept UniProtKB/Swiss-Prot:Q3UX62

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