Sh3bgrl SH3-binding domain glutamic acid-rich protein like [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Sh3bgrlprovided by MGI
Official Full Name: SH3-binding domain glutamic acid-rich protein likeprovided by MGI
Primary source: MGI:MGI:1930849
See related: Ensembl:ENSMUSG00000031246 AllianceGenome:MGI:1930849
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 1190008F14Rik
Summary: Predicted to enable protein-RNA adaptor activity and ubiquitin-like ligase-substrate adaptor activity. Predicted to be involved in positive regulation of cytoplasmic translational initiation and proteasome-mediated ubiquitin-dependent protein catabolic process. Predicted to be located in cytosol. Predicted to be active in cytoplasm. Is expressed in cerebral cortex and genitourinary system. Orthologous to human SH3BGRL (SH3 domain binding glutamate rich protein like). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Broad expression in bladder adult (RPKM 66.7), CNS E11.5 (RPKM 36.9) and 19 other tissues See more
Orthologs: human all
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Genomic context

Location:: X D; X 47.92 cM

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	X	NC_000086.8 (108139013..108206073)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	X	NC_000086.7 (109095407..109162467)

Chromosome X - NC_000086.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables SH3 domain binding	IEA Inferred from Electronic Annotation more info
enables molecular_function	ND No biological Data available more info
enables protein-RNA adaptor activity	IEA Inferred from Electronic Annotation more info
enables protein-RNA adaptor activity	ISO Inferred from Sequence Orthology more info
enables ubiquitin-like ligase-substrate adaptor activity	IEA Inferred from Electronic Annotation more info
enables ubiquitin-like ligase-substrate adaptor activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in biological_process	ND No biological Data available more info
involved_in positive regulation of cytoplasmic translational initiation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of cytoplasmic translational initiation	ISO Inferred from Sequence Orthology more info
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process	IEA Inferred from Electronic Annotation more info
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: adapter Sh3bgrl

Names: SH3 domain-binding glutamic acid-rich-like protein; SH3 domain-binding glutamic acid-rich-like protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_019989.2 → NP_064373.1 adapter Sh3bgrl

See identical proteins and their annotated locations for NP_064373.1

Status: PROVISIONAL

Source sequence(s)

BC043055

Consensus CDS

CCDS41102.1

UniProtKB/Swiss-Prot

A2ALN7, Q3UB57, Q9JJU8

UniProtKB/TrEMBL

Q3U9A8

Related

ENSMUSP00000033598.9, ENSMUST00000033598.9

Conserved Domains (1) summary

cd03030
Location:2 → 97

GRX_SH3BGR; Glutaredoxin (GRX) family, SH3BGR (SH3 domain binding glutamic acid-rich protein) subfamily; a recently-identified subfamily composed of SH3BGR and similar proteins possessing significant sequence similarity to GRX, but without a redox active CXXC motif. ...